Details of Drug-Drug Interaction
| Drug General Information (ID: DDICNW3HV4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Pancrelipase | Drug Info | Calcium carbonate | Drug Info | |||||
| Drug Type | Protein/peptide | Small molecule | |||||||
| Therapeutic Class | Digestive Enzymes | Antacids/Minerals And Electrolytes | |||||||
| Structure | |||||||||
| Mechanism of Pancrelipase-Calcium carbonate Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Pancrelipase | Calcium carbonate | |||||||
| Mechanism | Gastric pH sensitive | Gastric alkalinizer | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | The administration of antacids and enteric-coated pancreatic enzyme products should be separated by at least one hour. | ||||||||
| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cerner Multum, Inc. "Australian Product Information.". | ||||||||||||||||||
| 2 | Cerner Multum, Inc. "UK Summary of Product Characteristics.". | ||||||||||||||||||
| 3 | Multum Information Services, Inc. Expert Review Panel. | ||||||||||||||||||