Drug General Information (ID: DDICD5N6O4)
Drug Name			Picosulfuric acid		Drug Info		Benznidazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Trypanocidal Agents
Structure

Mechanism of Picosulfuric acid-Benznidazole Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Picosulfuric acid				Benznidazole
Mechanism		Picosulfuric acid				Decrease the laxative effect of Picosulfuric acid by reducing its hydrolysis by colonic bacteria to active metabolites
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Picosulfuric acid when combined with Benznidazole

Recommended Action
Management		Consider use of an alternate laxative in patients who have recently taken or are currently taking an antibiotic. If concomitant use is required, additional bowel cleansing and colonoscopy may be required.

References
1	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
2	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
3	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.