Details of Drug

Drug General Information (ID: D0162)
Drug Name	Benznidazole
Drug Type	Small molecule
Drug Synonymous	BENZNIDAZOLE; Radanil; Benzonidazole; 22994-85-0; Benznidazol; benzonidazol; Benznidazolum;Ro 07-1051; Rochagan; UNII-YC42NRJ1ZD; Benznidazolum [INN-Latin]; Benznidazol [INN-Spanish]; Ro 71051; NSC 299972; Benznidazole [INN]; CCRIS 2200 Click to Show/Hide
Disease Class	1F53: Chagas disease; 1D51-1F53: Trypanosomiasis
Therapeutic Class	Trypanocidal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C12H12N4O3
InChI	1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)
InChIKey	CULUWZNBISUWAS-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)CNC(=O)CN2C=CN=C2[N+](=O)[O-]
External Link
	Pubchem ID	31593
	CAS Number	22994-85-0
	CHEBI ID	133833
	TTD ID	D04XGT

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM018 Non-CYP450 enzyme inhibition BM074 Increased risk of peripheral neuropathy BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Benznidazole
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0081		Amprenavir (oral solution)	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3]
D0617		Ethanol	C2H6O	702	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16], [17], [18]
Pharmacodynamic additive effects
	Increased risk of peripheral neuropathy					Drug Num: 81
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[19], [20], [21]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[19], [20], [21]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[19], [20], [21]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[19], [20], [21]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[19], [20], [21]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[19], [20], [21]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[19], [20], [21]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[19], [20], [21]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[22], [23], [24]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[19], [25], [26]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[19], [20], [21]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[19], [20], [21]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[19], [20], [21]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[19], [20], [21]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[19], [20], [21]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[19], [20], [21]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[19], [20], [21]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[19], [20], [21]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[19], [20], [21]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[19], [20], [21]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[19], [20], [21]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[19], [20], [21]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[19], [20], [21]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[19], [20], [21]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[19], [20], [21]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[19], [20], [21]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[19], [20], [21]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[19], [20], [21]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[19], [20], [21]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[19], [20], [21]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[19], [20], [21]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[19], [20], [21]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[19], [20], [21]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[19], [20], [21]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[19], [20], [21]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[19], [20], [21]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[19], [20], [21]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[19], [20], [21]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[19], [20], [21]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[19], [20], [21]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[19], [20], [21]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[19], [20], [21]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[19], [20], [21]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[19], [20], [21]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[19], [20], [21]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[19], [20], [21]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[19], [20], [21]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[19], [20], [21]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[19], [20], [21]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[19], [20], [21]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[19], [20], [21]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[19], [20], [21]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[19], [20], [21]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[19], [20], [21]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[19], [20], [21]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[19], [20], [21]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[19], [20], [21]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[19], [20], [21]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[19], [20], [21]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[19], [20], [21]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[22], [34], [35]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[19], [20], [21]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[19], [20], [21]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[19], [20], [21]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[19], [20], [21]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[19], [20], [21]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[19], [20], [21]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[19], [20], [21]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[19], [20], [21]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[19], [20], [21]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[22], [36]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0509		Disulfiram	C10H20N2S4	3117	Major		Inter Info	[2], [8], [9]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[4], [5], [6]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[7]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[27]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[28], [29], [30]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[31], [32], [33]

References
1	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
2	Product Information. Metrogel-Vaginal (metronidazole). Curatek Pharmaceuticals Ltd, Elk Grove Village, IL.
3	Product Information. Tindamax (tinidazole). Presutti Laboratories Inc, Arlington Heights, IL.
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	UK government "Typhoid.".
6	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
7	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
8	Knee ST, Razani J "Acute organic brain syndrome: a complication of disulfiram therapy." Am J Psychiatry 131 (1974): 1281-2.[PMID: 4419107]
9	Scher JM "Psychotic reaction to disulfiram." JAMA 201 (1967): 175.[PMID: 6072487]
10	Alexander I "Alcohol-antabuse syndrome in patients receiving metronidazole during gynaecological treatment." Br J Clin Pract 39 (1985): 292-3. [PMID: 4027157]
11	Edwards DL, Fink PC, Van Dyke PO "Disulfiram-like reaction associated with intravenous trimethoprim-sulfamethoxazole and metronidazole." Clin Pharm 5 (1986): 999-1000. [PMID: 3492326]
12	Giannini AJ, DeFrance DT "Metronidazole and alcohol: potential for combinative abuse." J Toxicol Clin Toxicol 20 (1983): 509-15. [PMID: 6668631]
13	Harries DP, Teale KF, Sunderland G "Metronidazole and alcohol: potential problems." Scott Med J 35 (1990): 179-80. [PMID: 2077651]
14	Krulewitch CJ "An unexpected adverse drug effect." J Midwifery Womens Health 48 (2003): 67-8. [PMID: 12589307]
15	Product Information. Benznidazole (benznidazole). Everett Laboratories Inc, West Orange, NJ.
16	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
17	Visapaa JP, Tillonen JS, Kaihovaara PS, Salaspuro MP "Lack of disulfiram-like reaction with metronidazole and ethanol." Ann Pharmacother 36 (2002): 971-4. [PMID: 12022894]
18	Williams CS, Woodcock KR "Do ethanol and metronidazole interact to produce a disulfiram-like reaction?." Ann Pharmacother 34 (2000): 255-7. [PMID: 10676835]
19	Carrion C, Espinosa E, Herrero A, Garcia B "Possible vincristine-isoniazid interaction." Ann Pharmacother 29 (1995): 201. [PMID: 7756727]
20	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
21	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online."
22	Argov Z, Mastaglia FL "Drug-induced peripheral neuropathies." Br Med J 1 (1979): 663-6. [PMID: 219931]
23	Cavaletti G, Jakubowiak AJ "Peripheral neuropathy during bortezomib treatment of multiple myeloma: a review of recent studies." Leuk Lymphoma 51 (2010): 1178-87. [PMID: 20497001]
24	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
25	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
26	Product Information. Danyelza (naxitamab). Y-mAbs Therapeutics, New York, NY.
27	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
28	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
29	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
30	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
31	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
32	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
33	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
34	Cerner Multum, Inc. "Australian Product Information.".
35	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
36	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.

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