Drug General Information (ID: DDIB956WQH)
  Drug Name Elagolix Drug Info Prasterone enantate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Gonadotropin-Releasing Hormone Antagonists Androgens
  Structure

 Mechanism of Elagolix-Prasterone enantate Interaction (Severity Level: Moderate)
     Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Elagolix Prasterone enantate
      Mechanism Elagolix Decrease the therapeutic efficacy of elagolix
      Key Mechanism Factor 1
Factor Name Pharmacodynamics
Factor Description Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
      Mechanism Description
  • Attenuated pharmacological effects of  Elagolix when combined with Prasterone enantate 

Recommended Action
      Management Women requiring contraception should be advised to use non-hormonal forms of contraception during treatment with elagolix and for one week after its discontinuation.

References
1 Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
2 Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]
3 Weber A, Jager R, Borner A, et al. "Can grapefruit juice influence ethinyl estradiol bioavailability?" Contraception 53 (1996): 41-7. [PMID: 8631189]