Details of Drug

Drug General Information (ID: D0555)
Drug Name	Elagolix
Drug Type	Small molecule
Drug Synonymous	Elagolix; 834153-87-6; UNII-5B2546MB5Z; NBI-56418; 5B2546MB5Z; NBI56418; NBI 56418; Elagolix [USAN:INN]; Orilissa; ELA gOLIX; Elagolix (USAN/INN); SCHEMBL1642523; GTPL8362; CHEMBL1208155; DTXSID40232348; ABT-620; 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid; EX-A1765; BCP08827; ZINC49888891; CS-5329; SB16700; DB11979; compound 10b [PMID 19006286]; HY-14789; AN-27202; D09335; Z-3253; 153E876; Butanoic acid, 4-(((1R)-2-(5-(2-flu Click to Show/Hide
Disease Class	2E86: Uterine fibroid
Therapeutic Class	Gonadotropin-Releasing Hormone Antagonists
Structure
Structure	3D Structure		2D Structure
Formula	C32H30F5N3O5
InChI	1S/C32H30F5N3O5/c1-19-28(21-11-6-14-26(45-2)29(21)34)30(43)40(18-25(20-9-4-3-5-10-20)38-16-8-15-27(41)42)31(44)39(19)17-22-23(32(35,36)37)12-7-13-24(22)33/h3-7,9-14,25,38H,8,15-18H2,1-2H3,(H,41,42)/t25-/m0/s1
InChIKey	HEAUOKZIVMZVQL-VWLOTQADSA-N
Canonical SMILES	CC1=C(C(=O)N(C(=O)N1CC2=C(C=CC=C2F)C(F)(F)F)CC(C3=CC=CC=C3)NCCCC(=O)O)C4=C(C(=CC=C4)OC)F
External Link
	Pubchem ID	11250647
	CAS Number	834153-87-6
	TTD ID	D0UI3T

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM055 Increased risk of hepatotoxicity BM076 Increased risk of prolong QT interval BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Elagolix
Affected cellular transport
	Transporter inhibition					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[6], [14], [15], [16]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[17], [18], [19]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[5], [6], [64]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[98], [99], [100], [101]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[98], [100], [101]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[156]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[6], [166]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[169]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[161]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[98], [99], [100], [101]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[6], [242]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[296]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[5], [6], [323]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[325]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2], [3]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[43]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 198
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[10], [11], [12]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[10], [11], [12]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[21], [22]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[25], [26]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[25], [28]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[29]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[44]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[45], [46], [47], [48]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[49], [50], [51]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[1]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[52]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[53]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[5], [6], [54]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[55], [56], [57], [58], [59]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[60]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[61], [62]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[63]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[66]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[67], [68], [69]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[70]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[71], [72]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[74]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[1]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[75]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[77]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[80], [6], [81]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[6], [82]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[83]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[84], [85], [86], [4], [87], [88], [89], [90], [91], [92], [93], [94], [95], [49], [96], [50], [51]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[5], [6], [97]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[5], [6], [102]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[103]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[104]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[152]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[1]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[153]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[154]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[6], [155]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[5], [6], [157]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[158]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[159]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[160], [161]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[6], [162]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[163], [164], [165]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[167]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[5], [6], [168]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[1]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[170]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[6], [171]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[5], [175]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[163], [176]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[177]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[178]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[179]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[180]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[5], [6], [181]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[182]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[1]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[5], [6], [102]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[5], [6], [102]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[183], [184]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[185]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[186]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[5], [6], [187]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[188]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[189]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[190]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[84], [85], [86], [4], [87], [88], [89], [90], [91], [92], [93], [94], [95], [49], [96], [50], [51]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[1]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[183], [191]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[192]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[6], [193], [194]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[195]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[196], [4], [5], [6], [197], [198]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[204], [205], [210]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[6], [218]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[219], [220], [221], [222]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[223]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[224]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[5], [6], [225]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[1]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[226]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[5], [6], [227]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[228], [229]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[5], [230]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[231], [232], [151]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[233]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[109], [119], [144]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[5], [6], [102]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[5], [6], [102]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[235], [236]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[237], [238], [239], [240]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[1]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[241]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[243]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[245]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[4], [5], [6]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[109], [119], [144]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[109], [119], [144]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[5], [6], [246]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[1]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[163], [247], [165]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[248]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[249], [250], [251], [252]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[249], [250], [251]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[5], [6], [253]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[254]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[255]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[6], [256]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[1]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[257]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[5], [6], [258]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[259], [5], [260], [261]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[1]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[109], [119], [144]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[5], [262], [263], [264], [265]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[266], [267], [12], [268], [269], [270]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[271]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[272], [273], [274]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[5], [6], [275]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[1]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[1]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[5], [80], [6], [276]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[277]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[278]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[279]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[280]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[281]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[282], [283], [284], [285]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[5], [6], [286], [287]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[288]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[289]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[290]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[1]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[6], [197], [291]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[5], [6], [292]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[293]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[5], [6], [286], [287]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[6], [294], [295]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[297], [298], [299], [300]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[301]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[5], [6], [302]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[4], [6], [303], [304], [305]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[84], [85], [86], [4], [87], [88], [89], [90], [91], [92], [93], [94], [95], [49], [96], [50], [51]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[5], [308]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[6], [309]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[310], [5], [6], [298], [311]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[163], [313], [165]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[314]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[315]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[6], [316], [317], [318], [319]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[320]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[321], [219], [222]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[322]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[163], [324], [165]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[25], [326]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[327], [328], [329], [330]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[331]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[332], [333]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[20]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[4], [23], [24]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[27]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[42]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[4], [23], [24]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[65]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[6], [73]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[76]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[5], [6], [172], [173], [174]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[199], [200], [201], [202]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[199], [200], [201], [202]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[6], [234]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[244]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[199], [200], [201], [202]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[306], [307]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[6], [312]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[1], [78], [79]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[1], [78], [79]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[1], [78], [79]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[1], [78], [79]
D1327		Prasterone enantate	C26H40O3	163331	Moderate		Inter Info	[1], [78], [79]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[1], [78], [79]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[1], [78], [79]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[1], [78], [79]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[1], [78], [79]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[1], [78], [79]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[1], [78], [79]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[1], [78], [79]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[1], [78], [79]

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99	Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
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101	Product Information. Idamycin (idarubicin). Pharmacia and Upjohn, Kalamazoo, MI.
102	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
103	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
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153	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
154	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
155	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
156	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
157	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
158	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
159	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
160	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
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162	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
163	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
164	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
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167	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
168	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
169	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
170	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
171	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
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175	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
176	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
177	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
178	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
179	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
180	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
181	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
182	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
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185	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
186	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
187	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
188	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
189	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
190	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
191	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
192	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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195	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
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200	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
201	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
202	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
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213	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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218	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
219	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
220	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
221	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
222	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
223	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
224	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
225	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
226	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
227	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
228	Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
229	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
230	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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232	Product Information. Provera (medroxyprogesterone). Pharmacia and Upjohn, Kalamazoo, MI.
233	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
234	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
235	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
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237	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
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241	Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
242	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
243	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
244	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
245	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
246	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
247	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
248	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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250	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
251	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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253	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
254	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
255	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
256	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
257	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
258	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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260	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
261	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
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267	Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
268	Pukrittayakamee S, Prakongpan S, Wanwimolruk S, Clemens R, Looareesuwan S, White NJ "Adverse effect of rifampin on quinine efficacy in uncomplicated falciparum malaria." Antimicrob Agents Chemother 47 (2003): 1509-1513. [PMID: 12709315]
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271	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
272	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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274	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
275	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
276	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
277	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
278	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
279	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
280	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
281	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
282	Hyland R, Roe GH, Jones BC, Smith DA "Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil." Br J Clin Pharmaacol 51 (2001): 239-48. [PMID: 11298070]
283	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
284	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
285	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
286	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
287	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
288	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
289	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
290	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
291	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
292	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
293	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
294	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
295	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
296	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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303	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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313	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
314	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
315	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
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324	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
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326	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
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