Drug General Information (ID: DDI9UA0L4B)
Drug Name			Cidofovir		Drug Info		Iodixanol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Non-Ionic Iodinated Contrast Media
Structure

Mechanism of Cidofovir-Iodixanol Interaction (Severity Level: Major)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Cidofovir				Iodixanol
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Cidofovir and Iodixanol

Recommended Action
Management		Concomitant use of cidofovir with other potentially nephrotoxic agents (e.g., aminoglycosides polypeptide, glycopeptide, and polymyxin antibiotics amphotericin B aminosalicylates antiviral/antiretroviral agents such as acyclovir, adefovir, foscarnet, ganciclovir, and tenofovir antineoplastics such as aldesleukin, cisplatin, clofarabine, ifosfamide, streptozocin, and high intravenous dosages of methotrexate chelating agents such as deferasirox, deferoxamine, edetate disodium, and edetate calcium disodium immunosuppressants such as cyclosporine, everolimus, sirolimus, and tacrolimus intravascular contrast media intravenous bisphosphonates intravenous pentamidine high dosages and/or chronic use of nonsteroidal anti-inflammatory agents gallium nitrate lithium penicillamine) is considered contraindicated.

References
1	Product Information. Vistide (cidofovir). Gilead Sciences, Foster City, CA.