Details of Drug

Details of Drug

 Drug General Information (ID: D0832)
  Drug Name
Iodixanol
  Drug Type Small molecule
  Drug Synonymous
Acupaque; Visipaque; DU-6807; 2-5410-3A
    Click to Show/Hide
  Disease Class BA00-BE2Z: Cardiovascular disease
  Therapeutic Class Non-Ionic Iodinated Contrast Media
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C35H44I6N6O15
  InChI 1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62)
  InChIKey NBQNWMBBSKPBAY-UHFFFAOYSA-N
  Canonical SMILES CC(=O)N(CC(CN(C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I)C(=O)C)O)C2=C(C(=C(C(=C2I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I
  External Link
Pubchem ID 3724
CAS Number 92339-11-2
CHEBI ID 31705
TTD ID D0Y4YG

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
BM014  Interference of cell/tissue uptake
BM027  Decreased renal excretion due to nephrotoxicity
BM072  Increased risk of nephrotoxicity
BM081  Increased risk of ventricular arrhythmias
  Relation Graph
 Full list of drugs interacting with Iodixanol
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1822
 
Iodide I-123
 
I-
 
135300 
Moderate    Inter Info   
[18], [19], [20]
      Affected excretion pathways
   Decreased renal excretion due to nephrotoxicity Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1015
 
Metformin
 
C4H11N5
 
4091 
Major    Inter Info   
[9], [10], [11], [12], [13]
D1389
 
Remdesivir
 
C27H35N6O8P
 
121304016 
Moderate    Inter Info   
[18], [21], [22], [23], [24]
      Pharmacodynamic additive effects
   Increased risk of nephrotoxicity Drug Num:  89
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0022
 
Acyclovir
 
C8H11N5O3
 
135398513 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0056
 
Amikacin
 
C22H43N5O13
 
37768 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0057
 
Amikacin (liposome)
 
C22H43N5O13
 
37768 
Major    Inter Info   
[3], [4], [5]
D0075
 
Amphotericin B
 
C47H73NO17
 
5280965 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0076
 
Amphotericin B (cholesteryl sulfate)
 
C47H73NO17
 
5280965 
Major    Inter Info   
[3], [4], [5]
D0077
 
Amphotericin B (lipid complex)
 
C47H73NO17
 
5280965 
Major    Inter Info   
[3], [4], [5]
D0078
 
Amphotericin B (liposomal)
 
C47H73NO17
 
5280965 
Major    Inter Info   
[3], [4], [5]
D0142
 
Bacitracin
 
C66H103N17O16S
 
10909430 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0145
 
Balsalazide
 
C17H15N3O6
 
54585 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0335
 
Cidofovir
 
C8H14N3O6P
 
60613 
Major    Inter Info   
[8]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0383
 
Colistimethate
 
C58H105N16O28S5-5
 
70789202 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0434
 
Deferoxamine
 
C25H48N6O8
 
2973 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0476
 
Diclofenac
 
C14H11Cl2NO2
 
3033 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0489
 
Diflunisal
 
C13H8F2O3
 
3059 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0623
 
Etidronic acid
 
C2H8O7P2
 
3305 
Major    Inter Info   
[3], [4], [5]
D0624
 
Etodolac
 
C17H21NO3
 
3308 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0645
 
Fenoprofen
 
C15H14O3
 
3342 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0680
 
Flurbiprofen
 
C15H13FO2
 
3394 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0694
 
Foscarnet
 
CH3O5P
 
3415 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0718
 
Gentamicin
 
C21H43N5O7
 
3467 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0783
 
Ibandronate
 
C9H23NO7P2
 
60852 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0786
 
Ibuprofen
 
C13H18O2
 
3672 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0790
 
Ifosfamide
 
C7H15Cl2N2O2P
 
3690 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0800
 
Indomethacin
 
C19H16ClNO4
 
3715 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0549
 
Edetate calcium disodium anhydrous
 
C10H12CaN2Na2O8
 
6093170 
Major    Inter Info   
[3], [4], [5]
D0550
 
Edetate disodium anhydrous
 
C10H14N2Na2O8
 
8759 
Major    Inter Info   
[3], [4], [5]
D0629
 
Everolimus
 
C53H83NO14
 
6442177 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0709
 
Gallium nitrate
 
GaN3O9
 
61635 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0724
 
Givosiran
 
C78H139N11O30
 
119058042 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0805
 
Inotersen
 
C230H318N69O121P19S19
 
121492004 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Major    Inter Info   
[3], [4], [5]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Major    Inter Info   
[3], [4], [5]
D0964
 
Lutetium Lu 177 dotatate
 
C65H87LuN14O19S2
 
76966897 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1091
 
Moxetumomab Pasudotox
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1173
 
Olsalazine
 
C14H10N2O6
 
22419 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1304
 
Plazomicin
 
C25H48N6O10
 
42613186 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1442
 
Salsalate
 
C14H10O5
 
5161 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1542
 
Telavancin
 
C80H106Cl2N11O27P
 
3081362 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0876
 
Kanamycin
 
C18H36N4O11
 
6032 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0881
 
Ketoprofen
 
C16H14O3
 
3825 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0882
 
Ketorolac
 
C15H13NO3
 
3826 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0988
 
Meclofenamic acid
 
C14H11Cl2NO2
 
4037 
Major    Inter Info   
[3], [4], [5]
D0991
 
Mefenamic acid
 
C15H15NO2
 
4044 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0995
 
Meloxicam
 
C14H13N3O4S2
 
54677470 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1009
 
Mesalazine
 
C7H7NO3
 
4075 
Major    Inter Info   
[3], [4], [5]
D1097
 
Nabumetone
 
C15H16O2
 
4409 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1109
 
Naproxen
 
C14H14O3
 
156391 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1120
 
Neomycin
 
C23H46N6O13
 
8378 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1196
 
Oxaprozin
 
C18H15NO3
 
4614 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1217
 
Pamidronic acid
 
C3H11NO7P2
 
4674 
Major    Inter Info   
[3], [4], [5]
D1245
 
Penicillamine
 
C5H11NO2S
 
5852 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1246
 
Pentamidine
 
C19H24N4O2
 
4735 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1300
 
Piroxicam
 
C15H13N3O4S
 
54676228 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1310
 
Polymyxin B
 
C56H98N16O13
 
49800004 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1507
 
Streptomycin
 
C21H39N7O12
 
19649 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1508
 
Streptozocin
 
C8H15N3O7
 
29327 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1517
 
Sulfasalazine
 
C18H14N4O5S
 
5339 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1520
 
Sulindac
 
C20H17FO3S
 
1548887 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1597
 
Tobramycin
 
C18H37N5O9
 
36294 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1606
 
Tolmetin
 
C15H15NO3
 
5509 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1672
 
Valaciclovir
 
C13H20N6O4
 
135398742 
Major    Inter Info   
[3], [4], [5]
D1680
 
Vancomycin
 
C66H75Cl2N9O24
 
14969 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D1727
 
Zoledronic acid
 
C5H10N2O7P2
 
68740 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7]
D0012
 
Acetazolamide
 
C4H6N4O3S2
 
1986 
Moderate    Inter Info   
[14], [15], [16]
D0058
 
Amiloride
 
C6H8ClN7O
 
16231 
Moderate    Inter Info   
[14], [15], [16]
D0217
 
Bumetanide
 
C17H20N2O5S
 
2471 
Moderate    Inter Info   
[14], [15], [16]
D0321
 
Chlorothiazide
 
C7H6ClN3O4S2
 
2720 
Moderate    Inter Info   
[14], [15], [16]
D0326
 
Chlorthalidone
 
C14H11ClN2O4S
 
2732 
Moderate    Inter Info   
[14], [15], [16]
D0479
 
Diclofenamide
 
C6H6Cl2N2O4S2
 
3038 
Moderate    Inter Info   
[14], [15], [16]
D0613
 
Etacrynic acid
 
C13H12Cl2O4
 
3278 
Moderate    Inter Info   
[14], [15], [16]
D0704
 
Furosemide
 
C12H11ClN2O5S
 
3440 
Moderate    Inter Info   
[14], [15], [16]
D0771
 
Hydrochlorothiazide
 
C7H8ClN3O4S2
 
3639 
Moderate    Inter Info   
[14], [15], [16]
D0775
 
Hydroflumethiazide
 
C8H8F3N3O4S2
 
3647 
Moderate    Inter Info   
[14], [15], [16]
D0798
 
Indapamide
 
C16H16ClN3O3S
 
3702 
Moderate    Inter Info   
[14], [15], [16]
D1311
 
Polythiazide
 
C11H13ClF3N3O4S3
 
4870 
Moderate    Inter Info   
[14], [15], [16]
D1668
 
Urea
 
CH4N2O
 
1176 
Moderate    Inter Info   
[14], [15], [16]
D0978
 
Mannitol
 
C6H14O6
 
6251 
Moderate    Inter Info   
[14], [15], [16]
D1018
 
Methazolamide
 
C5H8N4O3S2
 
4100 
Moderate    Inter Info   
[14], [15], [16]
D1048
 
Metolazone
 
C16H16ClN3O3S
 
4170 
Moderate    Inter Info   
[14], [15], [16]
D1501
 
Spironolactone
 
C24H32O4S
 
5833 
Moderate    Inter Info   
[14], [15], [16]
D1611
 
Torasemide
 
C16H20N4O3S
 
41781 
Moderate    Inter Info   
[14], [15], [16]
D1631
 
Triamterene
 
C12H11N7
 
5546 
Moderate    Inter Info   
[14], [15], [16]
   Increased risk of ventricular arrhythmias Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[17]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[17]
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Moderate    Inter Info   
[17]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Moderate    Inter Info   
[17]
D1343
 
Procainamide
 
C13H21N3O
 
4913 
Moderate    Inter Info   
[17]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Moderate    Inter Info   
[17]
References
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11 Product Information. Glucophage (metformin). Bristol-Myers Squibb, Princeton, NJ.
12 Product Information. Ultravist (iopromide). Berlex, Richmond, CA.
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19 Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
20 Product Information. Visipaque (iodixanol). Nycomed Inc, Princeton, NJ.
21 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
22 European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
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24 US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".