Details of Drug

Drug General Information (ID: D0335)
Drug Name	Cidofovir
Drug Type	Small molecule
Drug Synonymous	CDV; Cidofovirum; Forvade; HPMPC; Vistide; Cidofovir anhydrous; GS 0504; GS 504; GS504; Cidofovir (Vistide); Cidofovir (anhydrous); GS-0504; GS-504; Vistide (TN); Vistide, Cidofovir; [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid; (2S)-3-Hydroxy-2-phosphonylmethoxypropyl-cytosine; (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine; (S)-1-[3-hydroxy-2-(phosphonylmethoxy)-propyl]cytosine; (S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl-1-(hydroxymethyl)ethoxy)methyl phosphonic acid; (S)-HPMPC; (s)-[[2-(4-amino-2-oxo-1(2h)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid; ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid; 1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine; 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]-cytosine dihydrate Click to Show/Hide
Disease Class	1D82: Cytomegaloviral disease
Therapeutic Class	Anti-Hiv Agents
Structure
Structure	3D Structure		2D Structure
Formula	C8H14N3O6P
InChI	1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
InChIKey	VWFCHDSQECPREK-LURJTMIESA-N
Canonical SMILES	C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O
External Link
	Pubchem ID	60613
	CAS Number	113852-37-2
	CHEBI ID	3696
	TTD ID	D04AAW
	VARIDT ID	DR00066

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM025 Decreased metabolism (Unspecific) BM027 Decreased renal excretion due to nephrotoxicity BM028 Competitive inhibition of renal tubular secretion BM072 Increased risk of nephrotoxicity BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Cidofovir
Affected cellular transport
	Transporter inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1436		Sacubitril	C24H29NO5	9811834	Moderate		Inter Info	[11], [15], [16]
D1528		Tafamidis	C14H7Cl2NO3	11001318	Moderate		Inter Info	[2], [17], [18]
Affected intra/extra-hepatic metabolism
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[1]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[7]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[8]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[9]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[10]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[11], [2], [12], [13], [14]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[19]
	Competitive inhibition of renal tubular secretion					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[2], [22], [23]
D0998		Memantine	C12H21N	4054	Minor		Inter Info	[24], [25], [26]
Pharmacodynamic additive effects
	Increased risk of nephrotoxicity					Drug Num: 94
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0030		Aldesleukin	NA	NA	Major		Inter Info	[1]
D0252		Capreomycin	C50H88N28O15	3000502	Major		Inter Info	[1]
D0022		Acyclovir	C8H11N5O3	135398513	Major		Inter Info	[1]
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[1]
D0075		Amphotericin B	C47H73NO17	5280965	Major		Inter Info	[1]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Major		Inter Info	[1]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Major		Inter Info	[1]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Major		Inter Info	[1]
D0142		Bacitracin	C66H103N17O16S	10909430	Major		Inter Info	[1]
D0145		Balsalazide	C17H15N3O6	54585	Major		Inter Info	[1]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1]
D0260		Carboplatin	C6H12N2O4Pt	426756	Major		Inter Info	[1]
D0298		Celecoxib	C17H14F3N3O2S	2662	Major		Inter Info	[1]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[1]
D0357		Clofarabine	C10H11ClFN5O3	119182	Major		Inter Info	[1]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Major		Inter Info	[1]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Major		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[1]
D0434		Deferoxamine	C25H48N6O8	2973	Major		Inter Info	[1]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1]
D0549		Edetate calcium disodium anhydrous	C10H12CaN2Na2O8	6093170	Major		Inter Info	[1]
D0550		Edetate disodium anhydrous	C10H14N2Na2O8	8759	Major		Inter Info	[1]
D0623		Etidronic acid	C2H8O7P2	3305	Major		Inter Info	[1]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1]
D0709		Gallium nitrate	GaN3O9	61635	Major		Inter Info	[1]
D0710		Ganciclovir	C9H13N5O4	135398740	Major		Inter Info	[1]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[1]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[4], [5], [6]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[4], [5], [6]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[4], [5], [6]
D0783		Ibandronate	C9H23NO7P2	60852	Major		Inter Info	[1]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Major		Inter Info	[1]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[1]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[1]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[1]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[1]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[1]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[1]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[1]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[1]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[1]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[1]
D0876		Kanamycin	C18H36N4O11	6032	Major		Inter Info	[1]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[1]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[1]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Major		Inter Info	[1]
D1091		Moxetumomab Pasudotox	NA	NA	Major		Inter Info	[1]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1]
D1120		Neomycin	C23H46N6O13	8378	Major		Inter Info	[1]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1]
D1173		Olsalazine	C14H10N2O6	22419	Major		Inter Info	[1]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1]
D1245		Penicillamine	C5H11NO2S	5852	Major		Inter Info	[1]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1]
D1310		Polymyxin B	C56H98N16O13	49800004	Major		Inter Info	[1]
D1421		Rofecoxib	C17H14O4S	5090	Major		Inter Info	[1]
D1442		Salsalate	C14H10O5	5161	Major		Inter Info	[1]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[1]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1]
D1508		Streptozocin	C8H15N3O7	29327	Major		Inter Info	[1]
D1517		Sulfasalazine	C18H14N4O5S	5339	Major		Inter Info	[1]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[1]
D1597		Tobramycin	C18H37N5O9	36294	Major		Inter Info	[1]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1]
D1672		Valaciclovir	C13H20N6O4	135398742	Major		Inter Info	[1]
D1674		Valdecoxib	C16H14N2O3S	119607	Major		Inter Info	[1]
D1676		Valganciclovir	C14H22N6O5	135413535	Major		Inter Info	[1]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Major		Inter Info	[1]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Major		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[1]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1]
D1009		Mesalazine	C7H7NO3	4075	Major		Inter Info	[1]
D1217		Pamidronic acid	C3H11NO7P2	4674	Major		Inter Info	[1]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[2], [3]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[2], [20], [21]

References
1	Product Information. Vistide (cidofovir). Gilead Sciences, Foster City, CA.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
4	Guo X, Nzerue C "How to prevent, recognize, and treat drug-induced nephrotoxicity.".
5	Centers for Disease Control and Prevention (CDC). Renal insufficiency and failure associated with immune globulin intravenous therapy--United States, 1985-1998.?MMWR Morb Mortal Wkly Rep. 1999;48(24):518-521. [PMID: 10401909]
6	Product Information. BabyBIG (botulism immune globulin). FFF Enterprises, Temecula, CA.
7	Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
8	Product Information. Ancobon (flucytosine). Roche Laboratories, Nutley, NJ.
9	Product Information. Eloxatin (oxaliplatin). Sanofi Winthrop Pharmaceuticals, New York, NY.
10	Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
11	Cerner Multum, Inc. "Australian Product Information.".
12	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
13	Gilead Sciences, Inc "About Remdesivir.".
14	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
15	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
16	Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
17	Product Information. Vyndaqel (tafamidis). Pfizer U.S. Pharmaceuticals Group, New York, NY.
18	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
19	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
20	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
21	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
22	Canadian Pharmacists Association "e-CPS."
23	Product Information. Sanctura (trospium chloride). Odyssey Pharmaceutical, East Hanover, NJ.
24	Ace LN, Jaffe JM, Kunka RL "Effect of food and an antacid on quinidine bioavailability." Biopharm Drug Dispos 4 (1983): 183-90. [PMID: 6882885]
25	Min DI, Ku YM, Geraets DR, Lee HC "Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers." J Clin Pharmacol 36 (1996): 469-76. [PMID: 8739026]
26	Product Information. Namenda (memantine). Forest Pharmaceuticals, St. Louis, MO.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence