Drug General Information (ID: DDI5SIOKUX)
Drug Name			Bempedoic acid		Drug Info		Delafloxacin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihyperammonia Agents				Quinolones/Antibiotics
Structure

Mechanism of Bempedoic acid-Delafloxacin Interaction (Severity Level: Major)
Increased risk of tendinitis/tendon rupture Click to Show/Hide Mechanism Graph
Drug Name		Bempedoic acid				Delafloxacin
Mechanism		Tendinitis/tendon rupture				Tendinitis/tendon rupture
Key Mechanism Factor 1
		Factor Name		Tendinitis/tendon rupture
		Factor Description		Tendons are tough bands of tissue that attach your muscles to your bones. A tendon rupture is a partial or complete tear of a tendon; tendonitis is inflammation or irritation of a tendon, a condition that causes pain and tenderness outside the joint.
Mechanism Description		Increased risk of tendinitis/tendon rupture by the combination of Bempedoic acid and Delafloxacin

Recommended Action
Management		Caution is recommended if bempedoic acid is prescribed in combination with corticosteroids or fluoroquinolones, particularly in patients with other concomitant risk factors (e.g., age over 60 years, renal failure, previous tendon disorders). Treatment with bempedoic acid should be stopped immediately if rupture of a tendon occurs. Discontinuation of treatment with bempedoic acid should be considered if the patient experiences joint pain, swelling, or inflammation. At the first sign of tendinitis or tendon rupture, the patient should be instructed to rest, avoid exercise, avoid using the affected area, and to contact their healthcare provider. An alternative therapy should be considered in patients with a history of tendon disorders or tendon rupture.

References
1	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
2	Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.