Details of Drug

Details of Drug

 Drug General Information (ID: D0438)
  Drug Name
Delafloxacin
  Drug Type Small molecule
  Drug Synonymous
Delafloxacin; 189279-58-1; ABT-492; WQ-3034; Abt 492; 1-(6-AMINO-3,5-DIFLUOROPYRIDIN-2-YL)-8-CHLORO-6-FLUORO-7-(3-HYDROXYAZETIDIN-1-YL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID; ABT492; RX-3341; UNII-6315412YVF; 6315412YVF; 1-(6-amino-3,5-difluoro-2-pyridyl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-quinoline-3-carboxylic acid; 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxoquinoline-3-carboxylic acid; Delafloxacin [USAN:INN]; Delafloxacinum; Delafloxacin (USAN)
    Click to Show/Hide
  Disease Class 1A00-1C4Z: Bacterial infection
  Therapeutic Class Quinolones/Antibiotics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C18H12ClF3N4O4
  InChI 1S/C18H12ClF3N4O4/c19-12-13-7(1-9(20)14(12)25-3-6(27)4-25)15(28)8(18(29)30)5-26(13)17-11(22)2-10(21)16(23)24-17/h1-2,5-6,27H,3-4H2,(H2,23,24)(H,29,30)
  InChIKey DYDCPNMLZGFQTM-UHFFFAOYSA-N
  Canonical SMILES C1C(CN1C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4=C(C=C(C(=N4)N)F)F)F)O
  External Link
Pubchem ID 487101
CAS Number 189279-58-1
TTD ID D0V9BU
INTEDE ID DR1895

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM002  Altered intestinal flora
BM003  Complex formation
BM006  Altered intestinal mucosa
BM010  Transporter inhibition
BM011  Transporter induction
BM019  UGT inhibition
BM023  UGT induction
BM028  Competitive inhibition of renal tubular secretion
BM038  Additive CNS depression effects
BM039  Additive CNS stimulant effects
BM064  Increased risk of hypoglycemia
BM069  Increased risk of lowers seizure threshold
BM080  Increased risk of tendinitis/tendon rupture
BM086  Antagonize the effect of antidiabetic agents
BM089  Antagonize the effect of antihypertensive agents
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Delafloxacin
      Affected gastrointestinal absorption
   Altered intestinal flora Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1094
 
Mycophenolate mofetil
 
C23H31NO7
 
5281078 
Moderate    Inter Info   
[136], [137]
D1095
 
Mycophenolic acid
 
C17H20O6
 
446541 
Moderate    Inter Info   
[136], [137]
   Complex formation Drug Num:  37
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0125
 
Attapulgite
 
Al2H29Mg2O15Si4-
 
56842194 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0236
 
Calcium carbonate
 
CCaO3
 
10112 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0238
 
Calcium citrate
 
C12H10Ca3O14
 
13136 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0241
 
Calcium gluconate
 
C12H22CaO14
 
9290 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0242
 
Calcium glycerophosphate
 
C3H7CaO6P
 
120096 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0244
 
Calcium Phosphate
 
Ca3O8P2
 
24456 
Moderate    Inter Info   
[56], [57], [67]
D0332
 
Chromium picolinate
 
C18H12CrN3O6
 
151932 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0390
 
Copper gluconate
 
C12H22CuO14
 
10692 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0239
 
Calcium glubionate anhydrous
 
C18H32CaO19
 
64776 
Moderate    Inter Info   
[56], [57], [67]
D0243
 
Calcium lactate
 
C6H10CaO6
 
13144 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0649
 
Ferrous fumarate
 
C4H2FeO4
 
6433164 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0650
 
Ferrous gluconate
 
C12H22FeO14
 
23616740 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0651
 
Ferrous sulfate anhydrous
 
FeO4S
 
24393 
Moderate    Inter Info   
[56], [57], [67]
D1566
 
Tetraferric tricitrate decahydrate
 
C18H32Fe4O31
 
90478690 
Moderate    Inter Info   
[56], [57], [67]
D1722
 
Zinc acetate
 
C4H6O4Zn
 
11192 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1723
 
Zinc chloride
 
Cl2Zn
 
5727 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0483
 
Didanosine
 
C10H12N4O3
 
135398739 
Moderate    Inter Info   
[97], [98], [99], [100], [101], [55], [102], [9], [2], [103], [104], [105], [106], [107]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[112], [113], [114]
D0847
 
Iron
 
Fe
 
23925 
Moderate    Inter Info   
[56], [57], [67]
D0849
 
Iron protein succinylate
 
NA
 
NA
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0877
 
Kaolin
 
Al2H4O9Si2
 
56841936 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0893
 
Lanthanum carbonate
 
C3La2O9
 
168924 
Moderate    Inter Info   
[14], [90], [27], [125], [126], [127]
D0967
 
Magaldrate
 
AlHMgO5S+2
 
3086011 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0968
 
Magnesium carbonate
 
CMgO3
 
11029 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0969
 
Magnesium chloride
 
Cl2H12MgO6
 
643991 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0970
 
Magnesium citrate
 
C12H10Mg3O14
 
6099959 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0972
 
Magnesium glycinate
 
C4H8MgN2O4
 
84645 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0974
 
Magnesium oxide
 
MgO
 
14792 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0975
 
Magnesium sulfate
 
MgO4S
 
24083 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Moderate    Inter Info   
[112], [113], [114]
D1456
 
Selenium
 
Se
 
6326970 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1462
 
Sevelamer
 
C6H12ClNO
 
3085017 
Moderate    Inter Info   
[140]
D1511
 
Sucralfate
 
C12H54Al9O55S8
 
121494085 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1724
 
Zinc gluconate
 
C12H22O14Zn
 
443445 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1725
 
Zinc sulfate
 
O4SZn
 
24424 
Moderate    Inter Info   
[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [9], [42], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
   Altered intestinal mucosa Drug Num:  55
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0030
 
Aldesleukin
 
NA
 
NA
Minor    Inter Info   
[133]
D0048
 
Altretamine
 
C9H18N6
 
2123 
Minor    Inter Info   
[133]
D0190
 
Bleomycin
 
C55H84N17O21S3+
 
5360373 
Minor    Inter Info   
[133]
D0223
 
Busulfan
 
C6H14O6S2
 
2478 
Minor    Inter Info   
[133]
D0249
 
Capecitabine
 
C15H22FN3O6
 
60953 
Minor    Inter Info   
[133]
D0260
 
Carboplatin
 
C6H12N2O4Pt
 
426756 
Minor    Inter Info   
[133]
D0264
 
Carmustine
 
C5H9Cl2N3O2
 
2578 
Minor    Inter Info   
[133]
D0312
 
Chlorambucil
 
C14H19Cl2NO2
 
2708 
Minor    Inter Info   
[133]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Minor    Inter Info   
[133]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Minor    Inter Info   
[133]
D0400
 
Cyclophosphamide
 
C7H15Cl2N2O2P
 
2907 
Minor    Inter Info   
[133]
D0404
 
Cytarabine
 
C9H13N3O5
 
6253 
Minor    Inter Info   
[133]
D0407
 
Dacarbazine
 
C6H10N6O
 
135398738 
Minor    Inter Info   
[133]
D0410
 
Dactinomycin
 
C62H86N12O16
 
457193 
Minor    Inter Info   
[133]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Minor    Inter Info   
[133]
D0430
 
Daunorubicin (liposomal)
 
C27H29NO10
 
30323 
Minor    Inter Info   
[133]
D0962
 
Lurbinectedin
 
C41H44N4O10S
 
57327016 
Minor    Inter Info   
[133]
D0442
 
Denileukin diftitox
 
NA
 
NA
Minor    Inter Info   
[133]
D0511
 
Docetaxel
 
C43H53NO14
 
148124 
Minor    Inter Info   
[133]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Minor    Inter Info   
[133]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Minor    Inter Info   
[133]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Minor    Inter Info   
[133]
D0627
 
Etoposide
 
C29H32O13
 
36462 
Minor    Inter Info   
[133]
D0666
 
Floxuridine
 
C9H11FN2O5
 
5790 
Minor    Inter Info   
[133]
D0669
 
Fludarabine
 
C10H12FN5O4
 
657237 
Minor    Inter Info   
[133]
D0675
 
Fluorouracil
 
C4H3FN2O2
 
3385 
Minor    Inter Info   
[133]
D0714
 
Gemcitabine
 
C9H11F2N3O4
 
60750 
Minor    Inter Info   
[133]
D0717
 
Gemtuzumab ozogamicin
 
NA
 
NA
Minor    Inter Info   
[133]
D0780
 
Hydroxyurea
 
CH4N2O2
 
3657 
Minor    Inter Info   
[133]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Minor    Inter Info   
[133]
D0790
 
Ifosfamide
 
C7H15Cl2N2O2P
 
3690 
Minor    Inter Info   
[133]
D0845
 
Irinotecan
 
C33H38N4O6
 
60838 
Minor    Inter Info   
[133]
D0945
 
Lomustine
 
C9H16ClN3O2
 
3950 
Minor    Inter Info   
[133]
D0986
 
Mechlorethamine
 
C5H11Cl2N
 
4033 
Minor    Inter Info   
[133]
D0996
 
Melphalan
 
C13H18Cl2N2O2
 
460612 
Minor    Inter Info   
[133]
D1007
 
Mercaptopurine
 
C5H4N4S
 
667490 
Minor    Inter Info   
[133]
D1077
 
Mitomycin
 
C15H18N4O5
 
5746 
Minor    Inter Info   
[133]
D1079
 
Mitoxantrone
 
C22H28N4O6
 
4212 
Minor    Inter Info   
[133]
D1212
 
Paclitaxel
 
C47H51NO14
 
36314 
Minor    Inter Info   
[133]
D1213
 
Paclitaxel (protein-bound)
 
C47H51NO14
 
36314 
Minor    Inter Info   
[133]
D1250
 
Pentostatin
 
C11H16N4O4
 
439693 
Minor    Inter Info   
[133]
D1305
 
Plicamycin
 
C52H76O24
 
163659 
Minor    Inter Info   
[133]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Minor    Inter Info   
[133]
D1508
 
Streptozocin
 
C8H15N3O7
 
29327 
Minor    Inter Info   
[133]
D1548
 
Temozolomide
 
C6H6N6O2
 
5394 
Minor    Inter Info   
[133]
D1551
 
Teniposide
 
C32H32O13S
 
452548 
Minor    Inter Info   
[133]
D1575
 
Thiotepa
 
C6H12N3PS
 
5453 
Minor    Inter Info   
[133]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Minor    Inter Info   
[133]
D1610
 
Topotecan
 
C23H23N3O5
 
60700 
Minor    Inter Info   
[133]
D1626
 
Tretinoin
 
C20H28O2
 
444795 
Minor    Inter Info   
[133]
D1667
 
Uracil mustard
 
C8H11Cl2N3O2
 
6194 
Minor    Inter Info   
[133]
D1697
 
Vinblastine
 
C46H58N4O9
 
13342 
Minor    Inter Info   
[133]
D1698
 
Vincristine
 
C46H56N4O10
 
5978 
Minor    Inter Info   
[133]
D1699
 
Vincristine (liposome)
 
C46H56N4O10
 
5978 
Minor    Inter Info   
[133]
D1700
 
Vinorelbine
 
C45H54N4O8
 
5311497 
Minor    Inter Info   
[133]
      Affected cellular transport
   Transporter inhibition Drug Num:  17
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Moderate    Inter Info   
[84]
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[27], [85], [86]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[27], [87], [88]
D0425
 
Darolutamide
 
C19H19ClN6O2
 
67171867 
Moderate    Inter Info   
[89]
D0568
 
Enasidenib
 
C19H17F6N7O
 
89683805 
Moderate    Inter Info   
[90], [91]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[92]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[90], [27], [93]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Moderate    Inter Info   
[27], [94]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[95]
D1539
 
Tedizolid
 
C17H15FN6O3
 
11234049 
Moderate    Inter Info   
[27], [96]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[27], [108]
D0700
 
Fostemsavir
 
C25H26N7O8P
 
11319217 
Moderate    Inter Info   
[115]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Moderate    Inter Info   
[27]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[128]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Moderate    Inter Info   
[132]
D1608
 
Tolvaptan
 
C26H25ClN2O3
 
216237 
Moderate    Inter Info   
[90], [27], [141], [142]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Moderate    Inter Info   
[143]
   Transporter induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[110], [90], [27], [111]
      Affected intra/extra-hepatic metabolism
   UGT induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[27], [74]
      Affected excretion pathways
   Competitive inhibition of renal tubular secretion Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0576
 
Entecavir
 
C12H15N5O3
 
135398508 
Moderate    Inter Info   
[109]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[133], [134], [135]
D1241
 
Pemetrexed
 
C20H21N5O6
 
135410875 
Moderate    Inter Info   
[138]
D1341
 
Probenecid
 
C13H19NO4S
 
4911 
Minor    Inter Info   
[42], [144], [145]
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  24
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0210
 
Bromfenac
 
C15H12BrNO3
 
60726 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0331
 
Choline salicylate
 
C12H19NO4
 
54686350 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0476
 
Diclofenac
 
C14H11Cl2NO2
 
3033 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0489
 
Diflunisal
 
C13H8F2O3
 
3059 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0624
 
Etodolac
 
C17H21NO3
 
3308 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0645
 
Fenoprofen
 
C15H14O3
 
3342 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0680
 
Flurbiprofen
 
C15H13FO2
 
3394 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0786
 
Ibuprofen
 
C13H18O2
 
3672 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0800
 
Indomethacin
 
C19H16ClNO4
 
3715 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0881
 
Ketoprofen
 
C16H14O3
 
3825 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0882
 
Ketorolac
 
C15H13NO3
 
3826 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0991
 
Mefenamic acid
 
C15H15NO2
 
4044 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D0995
 
Meloxicam
 
C14H13N3O4S2
 
54677470 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1097
 
Nabumetone
 
C15H16O2
 
4409 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1109
 
Naproxen
 
C14H14O3
 
156391 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1196
 
Oxaprozin
 
C18H15NO3
 
4614 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1300
 
Piroxicam
 
C15H13N3O4S
 
54676228 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1421
 
Rofecoxib
 
C17H14O4S
 
5090 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1442
 
Salsalate
 
C14H10O5
 
5161 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1520
 
Sulindac
 
C20H17FO3S
 
1548887 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1606
 
Tolmetin
 
C15H15NO3
 
5509 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
D1674
 
Valdecoxib
 
C16H14N2O3S
 
119607 
Moderate    Inter Info   
[42], [60], [2], [8], [76], [77], [41], [78], [79], [80], [81], [82], [83], [10]
   Additive CNS stimulant effects Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0017
 
Acetylsalicylic acid
 
C9H8O4
 
2244 
Moderate    Inter Info   
[41], [8], [42]
D0988
 
Meclofenamic acid
 
C14H11Cl2NO2
 
4037 
Moderate    Inter Info   
[41], [8], [42]
D1272
 
Phenyl salicylate
 
C13H10O3
 
8361 
Moderate    Inter Info   
[41], [8], [42]
D1439
 
Salicylic acid (sodium)
 
C7H6O3
 
338 
Moderate    Inter Info   
[41], [8], [42]
   Increased risk of hypoglycemia Drug Num:  17
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0009
 
Acarbose
 
C25H43NO18
 
41774 
Moderate    Inter Info   
[38], [39], [40]
D0029
 
Albiglutide
 
C148H224N40O45
 
145994868 
Moderate    Inter Info   
[38], [39], [40]
D0042
 
Alogliptin
 
C18H21N5O2
 
11450633 
Moderate    Inter Info   
[38], [39], [40]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[38], [39], [40]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[38], [39], [40]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[38], [39], [40]
D0930
 
Linagliptin
 
C25H28N8O2
 
10096344 
Moderate    Inter Info   
[38], [39], [40]
D0936
 
Liraglutide
 
C172H265N43O51
 
16134956 
Moderate    Inter Info   
[38], [39], [40]
D0941
 
Lixisenatide
 
C215H347N61O65S
 
90472060 
Moderate    Inter Info   
[38], [39], [40]
D1015
 
Metformin
 
C4H11N5
 
4091 
Moderate    Inter Info   
[38], [39], [40]
D1064
 
Miglitol
 
C8H17NO5
 
441314 
Moderate    Inter Info   
[38], [39], [40]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Moderate    Inter Info   
[38], [39], [40]
D1326
 
Pramlintide
 
C171H267N51O53S2
 
70691388 
Moderate    Inter Info   
[38], [39], [40]
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Moderate    Inter Info   
[38], [39], [40]
D1449
 
Saxagliptin
 
C18H25N3O2
 
11243969 
Moderate    Inter Info   
[38], [39], [40]
D1477
 
Sitagliptin
 
C16H15F6N5O
 
4369359 
Moderate    Inter Info   
[38], [39], [40]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[38], [39], [40]
   Increased risk of lowers seizure threshold Drug Num:  9
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[31], [32], [33], [34], [35]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[31], [32], [33], [34], [35]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[36], [25], [24], [37]
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[72], [73]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[90], [27]
D0722
 
Ginkgo biloba
 
NA
 
NA
Moderate    Inter Info   
[116], [117], [118], [119], [120], [121], [122], [123]
D0932
 
Lindane
 
C6H6Cl6
 
727 
Moderate    Inter Info   
[129], [130], [131]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[61], [139], [27]
   Increased risk of tendinitis/tendon rupture Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0155
 
Bempedoic acid
 
C19H36O5
 
10472693 
Major    Inter Info   
[4], [5]
D0172
 
Betamethasone
 
C22H29FO5
 
9782 
Major    Inter Info   
[6], [7], [8], [9], [2], [10], [11]
D0436
 
Deflazacort
 
C25H31NO6
 
189821 
Major    Inter Info   
[6], [7], [8], [9], [2], [10], [11]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Major    Inter Info   
[6], [7], [8], [9], [2], [10], [11]
D0671
 
Fludrocortisone
 
C21H29FO5
 
31378 
Major    Inter Info   
[6], [7], [8], [9], [2], [10], [11]
D0773
 
Hydrocortisone
 
C21H30O5
 
5754 
Major    Inter Info   
[6], [7], [8], [9], [2], [10], [11]
D1041
 
Methylprednisolone
 
C22H30O5
 
6741 
Major    Inter Info   
[6], [7], [8], [9], [2], [10], [11]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Major    Inter Info   
[6], [7], [8], [9], [2], [10], [11]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Major    Inter Info   
[6], [7], [8], [9], [2], [10], [11]
D1628
 
Triamcinolone
 
C21H27FO6
 
31307 
Major    Inter Info   
[6], [7], [8], [9], [2], [10], [11]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antidiabetic agents Drug Num:  26
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0013
 
Acetohexamide
 
C15H20N2O4S
 
1989 
Major    Inter Info   
[1], [2], [3]
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Major    Inter Info   
[1], [2], [3]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Major    Inter Info   
[1], [2], [3]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Major    Inter Info   
[1], [2], [3]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Major    Inter Info   
[1], [2], [3]
D0807
 
Insulin aspart (aspart protamine)
 
C256H381N65O79S6
 
118984445 
Major    Inter Info   
[1], [2], [3]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Major    Inter Info   
[1], [2], [3]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Major    Inter Info   
[1], [2], [3]
D0810
 
Insulin detemir
 
C267H402N64O76S6
 
16137271 
Major    Inter Info   
[1], [2], [3]
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Major    Inter Info   
[1], [2], [3]
D0812
 
Insulin glulisine
 
C258H384N64O78S6
 
16136701 
Major    Inter Info   
[1], [2], [3]
D0813
 
Insulin human
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[1], [2], [3]
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[1], [2], [3]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[1], [2], [3]
D0816
 
Insulin human (regular)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[1], [2], [3]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[1], [2], [3]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Major    Inter Info   
[1], [2], [3]
D0819
 
Insulin lispro
 
C257H389N65O77S6
 
16132438 
Major    Inter Info   
[1], [2], [3]
D0820
 
Insulin lispro (protamine)
 
C257H389N65O77S6
 
16132438 
Major    Inter Info   
[1], [2], [3]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Major    Inter Info   
[1], [2], [3]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Major    Inter Info   
[1], [2], [3]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Major    Inter Info   
[1], [2], [3]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Major    Inter Info   
[1], [2], [3]
D1779
 
Dulaglutide
 
NA
 
NA
Moderate    Inter Info   
[38], [39], [40]
D1782
 
Ertugliflozin
 
C22H25ClO7
 
44814423 
Moderate    Inter Info   
[38], [39], [40]
D1784
 
Exenatide
 
C184H282N50O60S
 
45588096 
Moderate    Inter Info   
[38], [39], [40]
   Antagonize the effect of antihypertensive agents Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1887
 
Semaglutide
 
C187H291N45O59
 
56843331 
Moderate    Inter Info   
[38], [39], [40]
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[27], [28], [29]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[30]
   Attenuated pharmacological effects (Unspecific) Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0145
 
Balsalazide
 
C17H15N3O6
 
54585 
Moderate    Inter Info   
[75]
D1817
 
Indium In-111 oxyquinoline
 
C27H18InN3O3
 
16685037 
Moderate    Inter Info   
[124]
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