Drug General Information (ID: DDIEHJGAIX)
Drug Name			Dulaglutide		Drug Info		Delafloxacin		Drug Info
Drug Type		Protein/peptide				Small molecule
Therapeutic Class		Antidiabetic Agents				Quinolones/Antibiotics

Mechanism of Dulaglutide-Delafloxacin Interaction (Severity Level: Moderate)
Antagonize the effect of antidiabetic agents Click to Show/Hide Mechanism Graph
Drug Name		Dulaglutide				Delafloxacin
Mechanism 1		Antidiabetic agent				Hyperglycemia
Key Mechanism Factor 1
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Dulaglutide when combined with Delafloxacin
Mechanism 2		Antidiabetic agent				Hyperglycemic effects
Key Mechanism Factor 2
		Factor Name		Antidiabetic agents
		Factor Description		The hypoglycemic effect of antidiabetes may be reduced, leading to higher blood glucose, increased blood glucose fluctuations, and the possibility of hyperglycemic complications
Mechanism Description		Antagonize the effect of Dulaglutide when combined with Delafloxacin

Recommended Action
Management		Blood glucose should be closely monitored whenever quinolones are prescribed to diabetic patients, especially if they are elderly, have renal impairment, or are severely ill. Patients should be apprised of the increased risk of dysglycemia and be particularly alert to potential signs and symptoms of hypoglycemia such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia. If hypoglycemia occurs, patients should initiate appropriate remedial therapy immediately, discontinue the quinolone, and contact their physician. alternative antibiotics may need to be considered.

References
1	Gavin JR 3rd, Kubin R, Choudhri S, et al "Moxifloxacin and glucose homeostasis: a pooled-analysis of the evidence from clinical and postmarketing studies." Drug Saf 27 (2004): 671-86. [PMID: 15230648]
2	Kelesidis T, Canseco E "Quinolone-induced hypoglycemia: a life-threatening but potentially reversible side effect." Am J Med 123 (2010): e5-6. [PMID: 20103009]
3	Yip C, Lee AJ "Gatifloxacin-induced hyperglycemia: a case report and summary of the current literature." Clin Ther 28 (2006): 1857-66. [PMID: 17213006]