Details of Drug

Details of Drug

 Drug General Information (ID: D0155)
  Drug Name
Bempedoic acid
  Drug Type Small molecule
  Drug Synonymous
ETC-1002; bempedoic acid; 738606-46-7; 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid; ESP-55016; UNII-1EJ6Z6Q368; ETC 1002; Bempedoic acid; ESP-55016; 1EJ6Z6Q368; Bempedoate; Bempedoic acid [USAN:INN]; ETC1002; ESP 55016; Bempedoic acid (USAN/INN); SCHEMBL185768; GTPL8321; CHEMBL3545313; HYHMLYSLQUKXKP-UHFFFAOYSA-N; EX-A1243; ZINC3948738; BCP16083; s7953; AKOS027439916; CS-3952; DB11936; AK499358; AC-29040; AS-49804; HY-12357; Bempedoic Acid(ETC-1002;ESP-55016); D10691; Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-
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  Disease Class BA00-BE2Z: Cardiovascular disease; 5C80: Hyper-lipoproteinaemia
  Therapeutic Class Antihyperammonia Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H36O5
  InChI 1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
  InChIKey HYHMLYSLQUKXKP-UHFFFAOYSA-N
  Canonical SMILES CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O
  External Link
Pubchem ID 10472693
CAS Number 738606-46-7
CHEBI ID 149601
TTD ID D0D9NY

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
BM010  Transporter inhibition
BM080  Increased risk of tendinitis/tendon rupture
  Relation Graph
 Full list of drugs interacting with Bempedoic acid
      Affected cellular transport
   Transporter inhibition Drug Num:  24
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1329
 
Pravastatin
 
C23H36O7
 
54687 
Major    Inter Info   
[3], [1], [2]
D1473
 
Simvastatin
 
C25H38O5
 
54454 
Major    Inter Info   
[3], [1], [2]
D0053
 
Ambrisentan
 
C22H22N2O4
 
6918493 
Moderate    Inter Info   
[1], [2]
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Moderate    Inter Info   
[1], [2]
D0726
 
Glecaprevir
 
C38H46F4N6O9S
 
66828839 
Moderate    Inter Info   
[4], [1], [2]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[1], [2]
D0303
 
Cerivastatin
 
C26H34FNO5
 
446156 
Moderate    Inter Info   
[1], [2]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[1], [2]
D0656
 
Fexofenadine
 
C32H39NO4
 
3348 
Moderate    Inter Info   
[1], [2]
D0686
 
Fluvastatin
 
C24H26FNO4
 
446155 
Moderate    Inter Info   
[1], [2]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Moderate    Inter Info   
[1], [2]
D0845
 
Irinotecan
 
C33H38N4O6
 
60838 
Moderate    Inter Info   
[1], [2]
D0956
 
Lovastatin
 
C24H36O5
 
53232 
Moderate    Inter Info   
[1], [2]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[1], [2]
D1170
 
Olmesartan
 
C24H26N6O3
 
158781 
Moderate    Inter Info   
[1], [2]
D1227
 
Paritaprevir
 
C40H43N7O7S
 
45110509 
Moderate    Inter Info   
[4], [1], [2]
D1301
 
Pitavastatin
 
C25H24FNO4
 
5282452 
Moderate    Inter Info   
[1], [2]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[1], [2]
D1396
 
Revefenacin
 
C35H43N5O4
 
11753673 
Moderate    Inter Info   
[1], [2], [5]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Moderate    Inter Info   
[4], [1], [2]
D1402
 
Rifaximin
 
C43H51N3O11
 
6436173 
Moderate    Inter Info   
[1], [2]
D1430
 
Rosuvastatin
 
C22H28FN3O6S
 
446157 
Moderate    Inter Info   
[1], [2]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[1], [2]
D1471
 
Simeprevir
 
C38H47N5O7S2
 
24873435 
Moderate    Inter Info   
[1], [2]
      Pharmacodynamic additive effects
   Increased risk of tendinitis/tendon rupture Drug Num:  24
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0438
 
Delafloxacin
 
C18H12ClF3N4O4
 
487101 
Major    Inter Info   
[1], [2]
D0172
 
Betamethasone
 
C22H29FO5
 
9782 
Major    Inter Info   
[1], [2]
D0215
 
Budesonide
 
C25H34O6
 
5281004 
Major    Inter Info   
[1], [2]
D0340
 
Cinoxacin
 
C12H10N2O5
 
2762 
Major    Inter Info   
[1], [2]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Major    Inter Info   
[1], [2]
D0436
 
Deflazacort
 
C25H31NO6
 
189821 
Major    Inter Info   
[1], [2]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Major    Inter Info   
[1], [2]
D0573
 
Enoxacin
 
C15H17FN4O3
 
3229 
Major    Inter Info   
[1], [2]
D0671
 
Fludrocortisone
 
C21H29FO5
 
31378 
Major    Inter Info   
[1], [2]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Major    Inter Info   
[1], [2]
D0716
 
Gemifloxacin
 
C18H20FN5O4
 
9571107 
Major    Inter Info   
[1], [2]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Major    Inter Info   
[1], [2]
D0773
 
Hydrocortisone
 
C21H30O5
 
5754 
Major    Inter Info   
[1], [2]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Major    Inter Info   
[1], [2]
D0943
 
Lomefloxacin
 
C17H19F2N3O3
 
3948 
Major    Inter Info   
[1], [2]
D1041
 
Methylprednisolone
 
C22H30O5
 
6741 
Major    Inter Info   
[1], [2]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Major    Inter Info   
[1], [2]
D1102
 
Nalidixic acid
 
C12H12N2O3
 
4421 
Major    Inter Info   
[1], [2]
D1155
 
Norfloxacin
 
C16H18FN3O3
 
4539 
Major    Inter Info   
[1], [2]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Major    Inter Info   
[1], [2]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Major    Inter Info   
[1], [2]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Major    Inter Info   
[1], [2]
D1499
 
Sparfloxacin
 
C19H22F2N4O3
 
60464 
Major    Inter Info   
[1], [2]
D1628
 
Triamcinolone
 
C21H27FO6
 
31307 
Major    Inter Info   
[1], [2]
References
1 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
2 Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
5 Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.