Details of Drug-Drug Interaction
| Drug General Information (ID: DDI0FZQK4U) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Sulfamethizole | Drug Info | Methenamine | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiinfective Agents | Urinary Antispasmodics | |||||||
| Structure | |||||||||
| Mechanism of Sulfamethizole-Methenamine Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Sulfamethizole | Methenamine | |||||||
| Mechanism | Sulfonamides | Increase the risk of urine crystal precipitation in combination with sulfonamides | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Adverse reactions | ||||||||
| Factor Description | An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Methenamine preparations should not be given to patients taking sulfonamides due to the risk of crystalluria. An alkalinizing agent should not be added because this may render methenamine less effective. | ||||||||
| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Product Information. Hiprex (methenamine). Hoechst Marion-Roussel Inc, Kansas City, MO. | ||||||||||||||||||
| 2 | Product Information. Urised (methenamine). Polymedica Pharmaceuticals USA Inc, Woburn, MA. | ||||||||||||||||||