Details of Drug

Drug General Information (ID: D1515)
Drug Name	Sulfamethizole
Drug Type	Small molecule
Drug Synonymous	Ayerlucil; Famet; Lucosil; Methazol; Microsul; Proklar; Renasul; Rufol; SULFAMETHIAZOLE; Salimol; Solfametizolo; Sulamethizole; Sulfamethazole; Sulfamethizol; Sulfamethizolum; Sulfamethylthiadiazole; Sulfametizol; Sulfapyelon; Sulfstat; Sulfurine; Sulphamethizole; Sulphamethyltiadiazole; Tetracid; Thidicur;Thiosulfil; Ultrasul; Urocydal; Urodiaton; Urolucosil; Urosulfin; Uroz; Solfametizolo [DCIT]; Sulfa gram; Thiosulfil Forte; RP 2145; VK 53; Sulfamethizolum [INN-Latin]; Sulfametizol [INN-Spanish]; Thiosulfil (TN); Sulfamethizole [USAN:INN:JAN]; Thiosulfil-A-Forte; Sulfamethizole (JP15/USP/INN); N1-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide; N(1)-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide; N(sup 1)-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide; N(sup 1)-(5-Methyl-1,3,4-thiadiazol-2-yl)-sulfanilamide; 2-(p-Aminobenzenesulfonamido)-5-methylthiadiazole; 2-Methyl-5-sulfanilamido-1,3,4-thiadiazole; 2-Sulfanilamido-5-methyl-1,3,4-thiadiazole; 4-Amino-N-(5-Methyl-1,3,4-Thiadiazol-2-Yl)Benzene-1-Sulfonamide; 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; 4-Amino-N-[5-methyl-1,3,4-thiadiazol-2-yl]benzenesulfonamide; 5-Methyl-2-sulfanilamido-1,3,4-thiadiazole Click to Show/Hide
Disease Class	GC08: Urinary tract infection
Therapeutic Class	Antiinfective Agents
Structure
Structure	3D Structure		2D Structure
Formula	C9H10N4O2S2
InChI	1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)
InChIKey	VACCAVUAMIDAGB-UHFFFAOYSA-N
Canonical SMILES	CC1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N
External Link
	Pubchem ID	5328
	CAS Number	144-82-1
	CHEBI ID	9331
	TTD ID	D07JJS

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM071 Increased risk of methemoglobinemia BM072 Increased risk of nephrotoxicity BM075 Increased risk of photosensitivity reactions BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Sulfamethizole
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[208], [209]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[208], [209]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[160], [161], [16], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[201]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[202], [203], [204]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[43]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[178], [179]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[205], [206]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[207]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[220], [221]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[224], [225], [226]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[5]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[8]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[12]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[41], [14], [42]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[156], [157], [158], [159]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[156], [157], [158], [159]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[180], [41], [181], [14], [16], [182], [183], [184], [185], [186], [187], [42], [188]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[180], [41], [181], [14], [16], [182], [183], [184], [185], [186], [187], [42], [188]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[191]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[192]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[180], [41], [181], [14], [16], [182], [183], [184], [185], [186], [187], [42], [188]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[16], [193]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[194]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[195], [196]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[200]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[210]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[156], [157], [158], [159]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[14], [16], [216], [217], [218]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[16], [219]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[222], [223]
	Increased risk of hypoglycemia					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [26], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [149], [60], [61], [62], [63], [64], [65], [66], [67], [69], [70], [71], [73], [74], [75], [76], [78], [79], [80], [82], [84], [85], [86], [87], [88], [89], [90], [91], [92], [94], [96], [98], [99], [100], [103], [104], [106], [107], [108], [110], [150], [112], [151], [152], [117], [153], [154], [123], [125], [126], [127], [129], [131], [133], [135], [136], [140], [141], [142], [143], [155], [144], [145], [147], [148]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[56], [112], [129]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[56], [112], [129]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[56], [112], [129]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[56], [112], [129]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[56], [112], [129]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [149], [60], [61], [62], [63], [64], [65], [66], [67], [69], [70], [71], [73], [74], [75], [76], [78], [79], [80], [82], [84], [85], [86], [87], [88], [89], [90], [91], [92], [94], [96], [98], [99], [100], [103], [104], [106], [107], [108], [110], [150], [112], [151], [152], [117], [153], [154], [123], [125], [126], [127], [129], [131], [133], [135], [136], [140], [141], [142], [143], [155], [144], [145], [147], [148]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[62], [77], [140]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [26], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [26], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[56], [112], [129]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [149], [60], [61], [62], [63], [64], [65], [66], [67], [69], [70], [71], [73], [74], [75], [76], [78], [79], [80], [82], [84], [85], [86], [87], [88], [89], [90], [91], [92], [94], [96], [98], [99], [100], [103], [104], [106], [107], [108], [110], [150], [112], [151], [152], [117], [153], [154], [123], [125], [126], [127], [129], [131], [133], [135], [136], [140], [141], [142], [143], [155], [144], [145], [147], [148]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [149], [60], [61], [62], [63], [64], [65], [66], [67], [69], [70], [71], [73], [74], [75], [76], [78], [79], [80], [82], [84], [85], [86], [87], [88], [89], [90], [91], [92], [94], [96], [98], [99], [100], [103], [104], [106], [107], [108], [110], [150], [112], [151], [152], [117], [153], [154], [123], [125], [126], [127], [129], [131], [133], [135], [136], [140], [141], [142], [143], [155], [144], [145], [147], [148]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [149], [60], [61], [62], [63], [64], [65], [66], [67], [69], [70], [71], [73], [74], [75], [76], [78], [79], [80], [82], [84], [85], [86], [87], [88], [89], [90], [91], [92], [94], [96], [98], [99], [100], [103], [104], [106], [107], [108], [110], [150], [112], [151], [152], [117], [153], [154], [123], [125], [126], [127], [129], [131], [133], [135], [136], [140], [141], [142], [143], [155], [144], [145], [147], [148]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [26], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [26], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[62], [77], [140]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[62], [77], [140]
	Increased risk of methemoglobinemia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[9], [10], [11]
D1338		Prilocaine (topical)	C13H20N2O	4906	Major		Inter Info	[13], [14], [15]
D0339		Cinchocaine (topical)	C20H29N3O2	3025	Moderate		Inter Info	[16], [44], [45]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[14], [46]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Moderate		Inter Info	[14], [46]
D1835		Lidocaine (ophthalmic)	C14H22N2O	3676	Moderate		Inter Info	[16], [44], [45]
D0928		Lidocaine (topical)	C14H22N2O	3676	Moderate		Inter Info	[16], [44], [45]
D0163		Benzocaine (topical)	C9H11NO2	2337	Moderate		Inter Info	[16], [44], [45]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[16], [44], [45]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[16], [44], [45]
D1852		Oxybuprocaine (ophthalmic)	C17H28N2O3	4633	Moderate		Inter Info	[16], [44], [45]
D1870		Proparacaine (ophthalmic)	C16H26N2O3	4935	Moderate		Inter Info	[16], [44], [45]
D1904		Tetracaine (ophthalmic)	C15H24N2O2	5411	Moderate		Inter Info	[16], [44], [45]
	Increased risk of nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1], [2], [3]
	Increased risk of photosensitivity reactions					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[14], [174], [175], [176], [177]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[14], [16], [189]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[14], [16], [189]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[214], [16], [215]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[16], [174], [175], [227]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1020		Methenamine	C6H12N4	4101	Major		Inter Info	[6], [7]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[16], [17], [18]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[19]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0059		Aminobenzoic acid	C7H7NO2	978	Major		Inter Info	[4]
D0688		Folic acid	C19H19N7O6	135398658	Moderate		Inter Info	[16], [47], [48]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[190]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[197], [198], [199]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[197], [198], [199]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[197], [198], [199]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[211], [212], [213]

References
1	Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50. [PMID: 2683269]
2	Ringden O, Myrenfors P, Klintmalm G, Tyden G, Ost L "Nephrotoxicity by co-trimoxazole and cyclosporin in transplanted patients." Lancet 1 (1984): 1016-7.[PMID: 6143932]
3	Berg K, Gjellestad A, Nordby G, et al "Renal effects of trimethoprim in ciclosporin- and azathioprine-treated kidney-allografted patients." Nephron 53 (1989): 218-22.[PMID: 2677807]
4	Product Information. Potaba (potassium aminobenzoate). Glenwood Inc, Englewood, NJ.
5	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
6	Product Information. Hiprex (methenamine). Hoechst Marion-Roussel Inc, Kansas City, MO.
7	Product Information. Urised (methenamine). Polymedica Pharmaceuticals USA Inc, Woburn, MA.
8	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
9	Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
10	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
11	Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
12	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
13	Canadian Pharmacists Association.
14	Cerner Multum, Inc. "Australian Product Information.".
15	Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
16	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
17	UK government "Typhoid.".
18	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
19	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
20	Cook DE, Ponte CD "Suspected trimethoprim sulfamethoxazole induced hypoprothrombinemia." J Fam Pract 39 (1994): 589-91. [PMID: 7798864]
21	Fischer HD, Juurlink DN, Mamdani MM, Kopp A, Laupacis A "Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study." Arch Intern Med 170 (2010): 617-21. [PMID: 20386005]
22	Glasheen JJ, Fugit RV, Prochazka AV "The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens." J Gen Intern Med 20 (2005): 653-6. [PMID: 16050864]
23	Hermans JJ, Thijssen HH "Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics." Br J Pharmacol 110 (1993): 482-90. [PMID: 8220911]
24	Hermida J, Zarza J, Alberca I, et al. "Differential effects of 2C93 and 2C92 variants of cytochrome P-450 CYP2C9 on sensitivity to acenocoumarol." Blood 99 (2002): 4237-9. [PMID: 12010835]
25	Kelly JG, O'Malley K "Clinical pharmacokinetics of oral anticoagulants." Clin Pharmacokinet 4 (1979): 1-15. [PMID: 369763]
26	Lumholtz B, Siersbaek-Nielsen K, Skovsted L, Kampmann J, Hansen JM "Sulfamethizole-induced inhibition of diphenylhydantoin, tolbutamide, and warfarin metabolism." Clin Pharmacol Ther 17 (1975): 731-4. [PMID: 1139863]
27	Miners JO, Birkett DJ "Cytochrome P4502C9: an enzyme of major importance in human drug metabolism." Br J Clin Pharmacol 45 (1998): 525-38. [PMID: 9663807]
28	O'Donnell D "Antibiotic-induced potentiation of oral anticoagulant agents." Med J Aust 150 (1989): 163-4. [PMID: 2716588]
29	O'Reilly RA "Stereoselective interaction of trimethoprim-sulfamethaxazole with the separated enantiomorphs of racemic warfarin in man." N Engl J Med 302 (1980): 33-5. [PMID: 7350395]
30	O'Reilly RA, Motley CH "Racemic warfarin and trimethoprim-sulfamethoxazole interaction in humans." Ann Intern Med 91 (1979): 34-6. [PMID: 464451]
31	Penning-van Beest F, Erkens J, Petersen KU, Koelz HR, Herings R "Main comedications associated with major bleeding during anticoagulant therapy with coumarins." Eur J Clin Pharmacol 61 (2005): 439-44. [PMID: 15947920]
32	Penning-van Beest FJ, van Meegen E, Rosendaal FR, Stricker BH "Drug interactions as a cause of overanticoagulation on phenprocoumon or acenocoumarol predominantly concern antibacterial drugs." Clin Pharmacol Ther 69 (2001): 451-7. [PMID: 11406743]
33	Self TH, Evans W, Ferguson T "Interaction of sulfisoxizole and warfarin." Circulation 52 (1975): 528. [PMID: 1157265]
34	Serlin MJ, Breckenridge AM "Drug interactions with warfarin." Drugs 25 (1983): 610-20. [PMID: 6347619]
35	Sioris LJ, Weibert RT, Pentel PR "Potentiation of warfarin anaticoagulation by sulfisoxazole." Arch Intern Med 140 (1980): 546-7. [PMID: 7362390]
36	Takahashi H, Wilkinson GR, Caraco Y, et al. "Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients." Clin Pharmacol Ther 73 (2003): 253-63. [PMID: 12621390]
37	Thijssen HH, Flinois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Disposition 28 (2000): 1284-90. [PMID: 11038154]
38	Venkatakrishnan K, vonMoltke LL, Greenblatt DJ "Effects of the antifungal agents on oxidative drug metabolism - Clinical relevance." Clin Pharmacokinet 38 (2000): 111-80. [PMID: 10709776]
39	Visser LE, Penning-Van Bees FJ, Harrie Kasbergen AA, et al. "Overanticoagulation associated with combined use of antibacterial drugs and acenocoumarol or phenprocoumon anticoagulants." Thromb Haemost 88 (2002): 705-10. [PMID: 12428081]
40	Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83. [PMID: 7944078]
41	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
42	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
43	Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
44	Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
45	Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
46	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
47	Mulenga M, Malunga P, Bennett S. et.al "Folic acid treatment of Zambian children with moderate to severe malaria anemia." Am J Trop Med Hyg 74 (2006): 986-90
48	Product Information. Folic Acid (folic acid). Method Pharmaceuticals, LLC, Arlington, TX.
49	Abad S, Moachon L, Blanche P, Bavoux F, Sicard D, Salmon-Ceron D "Possible interaction between glicazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia." Br J Clin Pharmacol 52 (2001): 456-7. [PMID: 11678792]
50	Ahmad S "Drug interaction induces hypoglycemia." J Fam Pract 40 (1995): 540-1. [PMID: 7775905]
51	Ahmad S "Gemfibrozil: interaction with glyburide." South Med J 84 (1991): 102. [PMID: 1898783]
52	Aleyassine H, Gardiner RJ "Dual action of antidepressant drugs (MAO inhibitors) on insulin release." Endocrinology 96 (1975): 702-10. [PMID: 1090438]
53	Aleyassine H, Lee SH "Inhibition of insulin release by substrates and inhibitors of monoamine oxidase." Am J Physiol 222 (1972): 565-9. [PMID: 5022664]
54	Almirall J, Montoliu J, Torras A, Revert L "Propoxyphene-induced hypoglycemia in a patient with chronic renal failure." Nephron 53 (1989): 273-5. [PMID: 2797348]
55	Arauz-Pacheco C, Ramirez LC, Rios JM, Raskin P "Hypoglycemia induced by angiotensin-converting enzyme inhibitors in patients with non-insulin-dependent diabetes receiving sulfonylurea therapy." Am J Med 89 (1990): 811-3. [PMID: 2123605]
56	Asplund K, Wiholm BE, Lithner F "Glibenclamide-associated hypoglycaemia: a report on 57 cases." Diabetologia 24 (1983): 412-7. [PMID: 6411511]
57	Baciewicz AM, Swafford WB Jr "Hypoglycemia induced by the interaction of chlorpropamide and co-trimoxazole." Drug Intell Clin Pharm 18 (1984): 309-10. [PMID: 6609055]
58	Barbato M "Another problem with Kinidin." Med J Aust 141 (1984): 685. [PMID: 6436654]
59	Baron SH "Salicylates as hypoglycemic agents." Diabetes Care 5 (1982): 64-71. [PMID: 6754304]
60	Cacoub P, Deray G, Baumelou A, Grimaldi A, Soubrie C, Jacobs C "Disopyramide-induced hypoglycemia: case report and review of the literature." Fundam Clin Pharmacol 3 (1989): 527-35. [PMID: 2691378]
61	Cattaneo AG, Caviezel F, Pozza G "Pharmacological interaction between tolbutamide and acetylsalicylic acid: study on insulin secretion in man." Int J Clin Pharmacol Ther Toxicol 28 (1990): 229-34. [PMID: 2198232]
62	Christensen LK, Hansen JM, Kristensen M "Sulphaphenazole-induced hypoglycemic attacks in tolbutamide-treated diabetics." Lancet 2 (1963): 1298-301. [PMID: 14071924]
63	Cooper AJ, Ashcroft G "Potentiation of insulin hypoglycaemia by M.A.O.I. antidepressant drugs." Lancet 1 (1966): 407-9. [PMID: 4159787]
64	Croxson MS, Shaw DW, Henley PG, Gabriel HDLL "Disopyramide-induced hypoglycaemia and increased serum insulin." N Z Med J July (1987): 407-8. [PMID: 3330586]
65	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
66	Daubresse JC, Daigneux D, Bruwier M, Luyckx A, Lefebvre PJ "Clofibrate and diabetes control in patients treated with oral hypoglycaemic agents." Br J Clin Pharmacol 7 (1979): 599-603. [PMID: 380614]
67	Daubresse JC, Luyckx AS, Lefebvre PJ "Potentiation of hypoglycemic effect of sulfonylureas by clofibrate." N Engl J Med 294 (1976): 613. [PMID: 1246250]
68	David DS, Steere AC Jr, Pi-Sunyer XF, Sakai S, Clark SB "Aspirin-induced hypoglycaemia in a patient on haemodialysis." Lancet 2 (1971): 1092-3. [PMID: 4106934]
69	Davis TM, Karbwang J, Looareesuwan S, et al "Comparative effects of quinine and quinidine on glucose metabolism in healthy volunteers." Br J Clin Pharmacol 30 (1990): 397-403. [PMID: 2223418]
70	de Salcedo I, Gorringe AL, Silva JL, Santos JA "Gemfibrozil in a group of diabetics." Proc R Soc Med 69 (1976): 64-70. [PMID: 1019155]
71	Deeg MA, Lipkin EW "Hypoglycemia associated with the use of fluoxetine." West J Med 164 (1996): 262-3. [PMID: 8775944]
72	Diwan PV, Sastry MS, Satyanarayana NV "Potentiation of hypoglycemic response of glibenclamide by piroxicam in rats and humans." Indian J Exp Biol 30 (1992): 317-9. [PMID: 1459600]
73	Feher MD, Amiel S "ACE inhibitors and hypoglycaemia." Lancet 346 (1995): 125-6. [PMID: 7603199]
74	Feldman JM, Chapman B "Monoamine oxidase inhibitors: nature of their interaction with rabbit pancreatic islets to alter insulin secretion." Diabetologia 11 (1975): 487-94. [PMID: 1107123]
75	Ferrari C, Fressati S, Romussi M, et al. "Effects of short-term clofibrate administration on glucose tolerance and insulin secretion in patients with chemical diabetes or hypertriglyceridemia." Metabolism 26 (1977): 129-39. [PMID: 834147]
76	Ferriere M, Lachkar H, Richard JL, Bringer J, Orsetti A, Mirouze J "Captopril and insulin sensitivity." Ann Intern Med 102 (1985): 134-5. [PMID: 3881067]
77	Field JB, Ohta M, Boyle C, Remer A "Potentiation of acetohexamide hypoglycemia by phenylbutazone." N Engl J Med 277 (1967): 889-94. [PMID: 6061822]
78	Fogari R, Zoppi A, Corradi L, Pierangelo L, Mugellini A, Lusardi P "Comparative effects of lisinopril and losartan on insulin sensitivity in the treatment of non diabetic hypertension." Br J Clin Pharmacol 46 (1998): 467-71. [PMID: 9833600]
79	Giugliano D, Ceriello A, Saccomanno F, et al "Effects of salicylate, tolbutamide, and prostaglandin E2 on insulin responses to glucose in noninsulin-dependent diabetes mellitus." J Clin Endocrinol Metab 61 (1985): 160-6. [PMID: 3923028]
80	Goldberg IJ, Brown LK, Rayfield EJ "Disopyramide (norpace)-induced hypoglycemia." Am J Med 69 (1980): 463-6. [PMID: 6998294]
81	Harris EL "Adverse reactions to oral antidiabetic agents." Br Med J 3 (1971): 29-30. [PMID: 5091891]
82	Harrison LC, King-Roach A, Martin FI, Melick RA "The effect of fenfluramine on insulin binding and on basal and insulin-stimulated oxidation of 1-C-glucose by human adipose tissue." Postgrad Med J 51 Suppl 1 (1975): 110-4. [PMID: 1219664]
83	Hartmann D, Korn A, Komjati M, Heinz G, Haefelfinger P, Defoin R, Waldhausl WK "Lack of effect of tenoxicam on dynamic responses to concurrent oral doses of glucose and glibenclamide." Br J Clin Pharmacol 30 (1990): 245-52. [PMID: 2119677]
84	Hayashi S, Horie M, Tsuura Y, Ishida H, Okada Y, Seino Y, Sasayama S "Disopyramide blocks pancreatic ATP-sensitive K+ channels and enhances insulin release." Am J Physiol 265 (1993): c337-42. [PMID: 8368263]
85	Hekimsoy Z, Biberoglu S, Comlekci A, Tarhan O, Mermut C, Biberoglu K "Trimethoprim/sulfamethoxazole-induced hypoglycemia in a malnourished patient with severe infection." Eur J Endocrinol 136 (1997): 3046. [PMID: 9100556]
86	Hellman B "Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells." Metabolism 23 (1974): 839-46. [PMID: 4212254]
87	Herings RMC, Deboer A, Stricker BHC, Leufkens HGM, Porsius A "Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme." Lancet 345 (1995): 1195-8. [PMID: 7739305]
88	Hundal RS, Petersen KF, Mayerson AB, et al "Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes." J Clin Invest 109 (2002): 1321-6. [PMID: 12021247]
89	Iida H, Morita T, Suzuki E, Iwasawa K, Toyooka T, Nakajima T "Hypoglycemia induced by interaction between clarithromycin and disopyramide." Jpn Heart J 40 (1999): 91-6. [PMID: 10370402]
90	Johnson J, Dobmeier M "Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction." DICP 24 (1990): 250-1. [PMID: 2316232]
91	Johnson JA, Kappel JE, Sharif MN "Hypoglycemia secondary to trimethoprim/sulfamethoxazole administration in a renal transplant patient." Ann Pharmacother 27 (1993): 304-6. [PMID: 8453166]
92	Konttinen A, Kuisma I, Ralli R, Pohjola S, Ojala K "The effect of gemfibrozil on serum lipids in diabetic patients." Ann Clin Res 11 (1979): 240-5. [PMID: 398183]
93	Kradjan WA, Witt DM, Opheim KE, Wood FC "Lack of interaction between glipizide and co-trimoxazole." J Clin Pharmacol 34 (1994): 997-1002. [PMID: 7836551]
94	Kubacka RT, Antla EJ, Juhl RP, Welshman IR "Effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects." Ann Pharmacother 30 (1996): 20-6. [PMID: 8773160]
95	Lozada A, Dujovne CA "Drug interactions with fibric acids." Pharmacol Ther 63 (1994): 163-76. [PMID: 7809177]
96	Morris AD, Newton RW, Boyle DI, et al. "ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes." Diabetes Care 20 (1997): 1363-7. [PMID: 9283780]
97	Morrison PJ, Rogers HJ, Spector RG, Bradbrook ID, John VA "Effect of pirprofen on glibenclamide kinetics and response." Br J Clin Pharmacol 14 (1982): 123-6. [PMID: 6809024]
98	Murakami K, Nambu S, Koh H, Kobayashi M, Shigeta Y "Clofibrate enhances the affinity of insulin receptors in non-insulin dependent diabetes mellitus." Br J Clin Pharmacol 17 (1984): 89-91. [PMID: 6362704]
99	Nakabayashi H, Ito T, Igawa T, Hiraiwa Y, Imamura T, Seta T, Kawato M, Usukura N, Takeda R "Disopyramide induces insulin secretion and plasma glucose diminution: studies using the in situ canine pancreas." Metabolism 38 (1989): 179-83. [PMID: 2643753]
100	Nappi JM, Dhanani S, Lovejoy JR, VanderArk C "Severe hypoglycemia associated with disopyramide." West J Med 138 (1983): 95-7. [PMID: 6404062]
101	Niemi M, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ, Kivisto KT "Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride." Clin Pharmacol Ther 69 (2001): 194-200. [PMID: 11309547]
102	Nikkila EA, Ylikahri R, Huttunen JK "Gemfibrozil: effect on serum lipids, lipoproteins, postheparin plasma lipase activities and glucose tolerance in primary hypertriglyceridaemia." Proc R Soc Med 69 (1976): 58-63. [PMID: 190608]
103	Paolisso G, Balbi V, Gambardella A, Varricchio G, Tortoriello R, Saccomanno F, Amato L, Varricchio M "Lisinopril administration improves insulin action in aged patients with hypertension." J Hum Hypertens 9 (1995): 541-6. [PMID: 7562882]
104	Pestell RG, Crock PA, Ward GM, Alford FP, Best JD "Fenfluramine increases insulin action in patients with NIDDM." Diabetes Care 12 (1989): 252-8. [PMID: 2495916]
105	Petitpierre B, Perrin L, Rudhardt M, et al "Behaviour of chlorpropamide in renal insufficiency and under the effect of associated drug therapy." Int J Clin Pharmacol 6 (1972): 120-4. [PMID: 4638970]
106	Phillips AF, Matty PJ, Porte PJ, Raye JR "Inhibition of glucose-induced insulin secretion by indomethacin and sodium salicylate in the fetal lamb." Am J Obstet Gynecol 148 (1984): 481-7. [PMID: 6364813]
107	Phillips RE, Looareesuwan S, White NJ, et al "Hypoglycaemia and antimalarial drugs: quinidine and release of insulin." Br Med J 292 (1986): 1319-21. [PMID: 3085830]
108	Pollak PT, Mukherjee SD, Fraser AD "Sertraline-induced hypoglycemia." Ann Pharmacother 35 (2001): 1371-4. [PMID: 11724085]
109	Pond SM, Birkett DJ, Wade DN "Mechanisms of inhibition of tolbutamide metabolism: phenylbutazone, oxyphenbutazone, sulfaphenazole." Clin Pharmacol Ther 22 (1977): 573-9. [PMID: 913025]
110	Prince RL, Larkins RG, Alford FP "The effect of acetylsalicylic acid on plasma glucose and the response of glucose regulatory hormones to intravenous glucose and arginine in insulin treated diabetics and normal subjects." Metabolism 30 (1981): 293-8. [PMID: 7010074]
111	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
112	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
113	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
114	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
115	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
116	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
117	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
118	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
119	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
120	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
121	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
122	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
123	Quevedo SF, Krauss DS, Chazan JA, et al "Fasting hypoglycemia secondary to disopyramide therapy." JAMA 245 (1981): 2424. [PMID: 6785461]
124	Ravic M, Johnston A, Turner P "Clinical pharmacological studies of some possible interactions of lornoxicam with other drugs." Postgrad Med J 66 (1990): s30-4. [PMID: 2126624]
125	Richardson T, Foster J, Mawer GE "Enhancement by sodium salicylate of the blood glucose lowering effect of chlorpropamide-drug interaction or summation of similar effects." Br J Clin Pharmacol 22 (1986): 43-8. [PMID: 3527244]
126	Rubin M, Zakheim B, Pitchumoni C "Disopyramide-induced profound hypoglycemia." N Y State J Med July,Aug,S (1983): 1057-8. [PMID: 6579404]
127	Salmela PI, Sotaniemi EA, Viikari J, et al "Fenfluramine therapy in non-insulin-dependent diabetic patients effects on body weight, glucose homeostasis, serum lipoproteins, and antipyrine metabolism." Diabetes Care 4 (1981): 535-40. [PMID: 6751729]
128	Sawka AM, Burgart V, Zimmerman D "Loss of awareness of hypoglycemia temporally associated with selective serotonin reuptake inhibitors." Diabetes Care 24 (2001): 1845-6. [PMID: 11574457]
129	Semel JD, Wortham E, Karl DM "Fasting hypoglycemia associated with disopyramide." Am Heart J 106 (1983): 1160-1. [PMID: 6356848]
130	Shah SJ, Bhandarkar SD, Satoskar RS "Drug interaction between chlorpropamide and non-steroidal anti-flammatory drugs, ibuprofen and phenylbutazone." Int J Clin Pharmacol Ther Toxicol 22 (1984): 470-2. [PMID: 6500764]
131	Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V "Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia." Eur J Clin Nutr 57 (2003): 243-8. [PMID: 12571655]
132	Sjoberg S, Wiholm BE, Gunnarsson R, Emilsson H, Thunberg E, Christenson I, Ostman J "Lack of pharmacokinetic interaction between glibenclamide and trimethoprim-sulphamethoxazole." Diabet Med 4 (1987): 245-7. [PMID: 2956028]
133	Slade IH, and Iosefa RN "Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases." J Am Geriatr Soc 15 (1967): 948-50. [PMID: 6046558]
134	Sone H, Takahashi A, Yamada N "Ibuprofen-related hypoglycemia in a patient receiving sulfonylurea." Ann Intern Med 134 (2001): 344. [PMID: 11182854]
135	Storlien LH, Thorburn AW, Smythe GA, Jenkins AB, Chisholm DJ, Kraegen EW "Effect of d-fenfluramine on basal glucose turnover and fat-feeding-induced insulin resistance in rats." Diabetes 38 (1989): 499-503. [PMID: 2647557]
136	Strathman I, Schubert EN, Cohen A, Nitzberg DM "Hypoglycemia in patients receiving disopyramide phosphate." Drug Intell Clin Pharm 17 (1983): 635-8. [PMID: 6413187]
137	Tannenbaum H, Anderson LG, Soeldner JS "Phenylbutazone-tolbutamide drug interaction." N Engl J Med 290 (1974): 344. [PMID: 4809290]
138	Tran PO, Gleason CE, Robertson RP "Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function." Diabetes 51 (2002): 1772-8. [PMID: 12031964]
139	Tremaine LM, Wilner KD, Preskorn SH "A study of the potential effect of sertraline on the pharmacokinetics and protein binding of tolbutamide." Clin Pharmacokinet 32(Suppl 1) (1997): 31-36. [PMID: 9068933]
140	Turtle JR, Burgess JA "Hypoglycemic action of fenfluramine in diabetes mellitus." Diabetes 22 (1973): 858-67. [PMID: 4749404]
141	Verdy M, Charbonneau L, Verdy I, Belanger R, Bolte E, Chiasson JL "Fenfluramine in the treatment of non-insulin-dependent diabetics: hypoglycemic versus anorectic effect." Int J Obes 7 (1983): 289-97. [PMID: 6629637]
142	Vuksan V, Sievenpiper JL, Koo VY, et al "American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus." Arch Intern Med 160 (2000): 1009-13. [PMID: 10761967]
143	Vuksan V, Stavro MP, Sievenpiper JL, et al "Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes." Diabetes Care 23 (2000): 1221-6. [PMID: 10977009]
144	Whitcroft IA, Thomas JM, Rawsthorne A, et al "Effects of alpha and beta adrenoceptor blocking drugs and ACE inhibitors on long term glucose and lipid control in hypertensive non-insulin dependent diabetics." Horm Metab Res Suppl 22 (1990): 42-6. [PMID: 1975246]
145	Wiederholt IC, Genco M, Foley JM "Recurrent episodes of hypoglycemia induced by propoxyphene." Neurology 17 (1967): 703-6. [PMID: 6067489]
146	Wing LM, Miners JO "Cotrimoxazole as an inhibitor of oxidative drug metabolism: effects of trimethoprim and sulphamethoxazole separately and combined on tolbutamide disposition." Br J Clin Pharmacol 20 (1985): 482-5. [PMID: 3878154]
147	World Health Organization "WHO Public Assessment Reports (WHOPARs).".
148	Wu B, Sato T, Kiyosue T, Arita M "Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs." Cardiovasc Res 26 (1992): 1095-101. [PMID: 1291087]
149	Ben Salem C, Fathallah N, Hmouda H, Bouraoui K "Drug-induced hypoglycaemia: an update." Drug Saf 34 (2011): 21-45. [PMID: 20942513]
150	Product Information. Afrezza (insulin inhalation, rapid acting). MannKind Corporation, Valencia, CA.
151	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
152	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
153	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
154	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
155	Vuorinen-Markkola H, Yki-Jarvinen H "Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus." Metabolism 44 (1995): 85-9. [PMID: 7854171]
156	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
157	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
158	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
159	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
160	Bannwarth B, Pehourcq F, Schaeverbeke T, Dehais J "Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis." Clin Pharmacokinet 30 (1996): 194-210. [PMID: 8882301]
161	Beach BJ, Woods WG, Howell SB "Influence of co-trimoxazole on methotrexate pharmacokinetics in children with acute lymphoblastic leukemia." Am J Pediatr Hematol Oncol 3 (1981): 115-9. [PMID: 6975580]
162	Ferrazzini G, Klein J, Sulh H, Chung D, Griesbrecht E, Koren G "Interaction between trimethoprim-sulfamethoxazole and methotrexate in children with leukemia." J Pediatr 117 (1990): 823-6. [PMID: 2231218]
163	Frain JB "Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole." J Rheumatol 14 (1987): 176-7. [PMID: 3494846]
164	Govert JA, Patton S, Fine RL "Pancytopenia from using trimethoprim and methotrexate." Ann Intern Med 117 (1992): 877-8. [PMID: 1416570]
165	Jeurissen ME, Boerbooms AM, van de Putte LB "Pancytopenia and methotrexate with trimethoprim-sulfamethoxazole." Ann Intern Med 111 (1989): 261. [PMID: 2787612]
166	Liegler DG, Henderson ES, Hahn MA, Oliverio VT "The effect of organic acids on renal clearance of methotrexate in man." Clin Pharmacol Ther 10 (1969): 849-57. [PMID: 5349626]
167	Ng HW, Macfarlane AW, Graham RM, Verbov JL "Near fatal drug interactions with methotrexate given for psoriasis." Br Med J (Clin Res Ed) 295 (1987): 752-3. [PMID: 3119023]
168	Product Information. Bactrim (trimethoprim-sulfamethoxazole). Roche Laboratories, Nutley, NJ.
169	Product Information. Rheumatrex (methotrexate). Lederle Laboratories, Wayne, NJ.
170	Product Information. Sulfadiazine (sulfadiazine). Eon Labs Manufacturing Inc, Laurelton, NY.
171	Thomas DR, Dover JS, Camp RD "Pancytopenia induced by the interaction between methotrexate and trimethoprim-sulfamethoxazole." J Am Acad Dermatol 17 (1987): 1055-6. [PMID: 3501437]
172	Thomas MH, Gutterman LA "Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole." J Rheumatol 13 (1986): 440-1. [PMID: 3487652]
173	Verbov JL "Methotrexate and trimethoprim-sulfamethoxazole." Clin Exp Dermatol 16 (1991): 231. [PMID: 1934583]
174	Multum Information Services, Inc. Expert Review Panel.
175	Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
176	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
177	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
178	Karonen T, Filppula A, Laitila J, Niemi M, Neuvonen PJ, Backman JT "Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast." Clin Pharmacol Ther (2010):. [PMID: 20592724]
179	Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
180	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
181	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
182	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
183	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
184	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
185	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
186	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
187	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
188	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
189	Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
190	Product Information. Colazal (balsalazide) Salix Pharmaceuticals, Palo Alto, CA.
191	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
192	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
193	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
194	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
195	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
196	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
197	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
198	Barnett ML "Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration." J Periodontol 56 (1985): 18-20. [PMID: 3882930]
199	King VJ "OC failure rates and oral antibiotics." J Fam Pract 45 (1997): 104-5. [PMID: 9267366]
200	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
201	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
202	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
203	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
204	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
205	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
206	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
207	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
208	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
209	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
210	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
211	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
212	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
213	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
214	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
215	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
216	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
217	Gilead Sciences, Inc "About Remdesivir.".
218	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
219	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
220	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
221	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
222	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
223	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
224	Miners JO, Rees DLP, Valente L, Veronese ME, Birkett DJ "Human hepatic cytochrome p450 2c9 catalyzes the rate-limiting pathway of torsemide metabolism." J Pharmacol Exp Ther 272 (1995): 1076-81. [PMID: 7891318]
225	Product Information. Demedex (torsemide). Boehringer Mannheim, Gaithersburg, MD.
226	Vormfelde SV, Engelhardt S, Zirk A, et al. "CYP2C9 polymorphisms and the interindividual variability in pharmacokinetics and pharmacodynamics of the loop diuretic drug torsemide." Clin Pharmacol Ther 76 (2004): 557-66. [PMID: 15592327]
227	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.

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