Drug General Information (ID: DDIEGMU15A)
Drug Name			Cyclosporine		Drug Info		Sulfamethizole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Antiinfective Agents
Structure

Mechanism of Cyclosporine-Sulfamethizole Interaction (Severity Level: Major)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Cyclosporine				Sulfamethizole
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Cyclosporine and Sulfamethizole

Recommended Action
Management		Renal function and cyclosporine levels should be closely monitored if these drugs must be used concomitantly.

References
1	Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50. [PMID: 2683269]
2	Ringden O, Myrenfors P, Klintmalm G, Tyden G, Ost L "Nephrotoxicity by co-trimoxazole and cyclosporin in transplanted patients." Lancet 1 (1984): 1016-7.[PMID: 6143932]
3	Berg K, Gjellestad A, Nordby G, et al "Renal effects of trimethoprim in ciclosporin- and azathioprine-treated kidney-allografted patients." Nephron 53 (1989): 218-22.[PMID: 2677807]