Details of Drug

Details of Drug

 Drug General Information (ID: D1020)
  Drug Name
Methenamine
  Drug Type Small molecule
  Drug Synonymous
Hiprex; Methenamine Hippurate
    Click to Show/Hide
  Disease Class GC08: Urinary tract infection
  Therapeutic Class Urinary Antispasmodics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C6H12N4
  InChI 1S/C6H12N4/c1-7-2-9-4-8(1)5-10(3-7)6-9/h1-6H2
  InChIKey VKYKSIONXSXAKP-UHFFFAOYSA-N
  Canonical SMILES C1N2CN3CN1CN(C2)C3
  External Link
Pubchem ID 4101
CAS Number 100-97-0
CHEBI ID 6824
TTD ID D02LJR

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM014  Interference of cell/tissue uptake
BM029  Altered urine pH
BM107  Attenuated pharmacological effects (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Methenamine
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1817
 
Indium In-111 oxyquinoline
 
C27H18InN3O3
 
16685037 
Moderate    Inter Info   
[10]
      Affected excretion pathways
   Altered urine pH Drug Num:  31
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0012
 
Acetazolamide
 
C4H6N4O3S2
 
1986 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0058
 
Amiloride
 
C6H8ClN7O
 
16231 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0074
 
Amphetamine
 
C9H13N
 
3007 
Moderate    Inter Info   
[7], [8], [9]
D0158
 
Bendroflumethiazide
 
C15H14F3N3O4S2
 
2315 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0165
 
Benzphetamine
 
C17H21N
 
5311017 
Moderate    Inter Info   
[7], [8], [9]
D0166
 
Benzthiazide
 
C15H14ClN3O4S3
 
2343 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0236
 
Calcium carbonate
 
CCaO3
 
10112 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0321
 
Chlorothiazide
 
C7H6ClN3O4S2
 
2720 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0326
 
Chlorthalidone
 
C14H11ClN2O4S
 
2732 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0465
 
Dextroamphetamine
 
C9H13N
 
5826 
Moderate    Inter Info   
[7], [8], [9]
D0479
 
Diclofenamide
 
C6H6Cl2N2O4S2
 
3038 
Moderate    Inter Info   
[3], [4], [1]
D0771
 
Hydrochlorothiazide
 
C7H8ClN3O4S2
 
3639 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0775
 
Hydroflumethiazide
 
C8H8F3N3O4S2
 
3647 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0798
 
Indapamide
 
C16H16ClN3O3S
 
3702 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0886
 
Lactic acid
 
C3H6O3
 
612 
Moderate    Inter Info   
[3], [4], [1]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[7], [8], [9]
D0974
 
Magnesium oxide
 
MgO
 
14792 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D1012
 
Metamfetamine
 
C10H15N
 
10836 
Moderate    Inter Info   
[7], [8], [9]
D1018
 
Methazolamide
 
C5H8N4O3S2
 
4100 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0967
 
Magaldrate
 
AlHMgO5S+2
 
3086011 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0968
 
Magnesium carbonate
 
CMgO3
 
11029 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D1319
 
Potassium citrate
 
C6H5K3O7
 
13344 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D1478
 
Sodium acetate
 
C2H3NaO2
 
517045 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D1483
 
Sodium citrate
 
C6H5Na3O7
 
6224 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D1048
 
Metolazone
 
C16H16ClN3O3S
 
4170 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D1311
 
Polythiazide
 
C11H13ClF3N3O4S3
 
4870 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D1480
 
Sodium bicarbonate
 
CHNaO3
 
516892 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D1633
 
Trichlormethiazide
 
C8H8Cl3N3O4S2
 
5560 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
D1654
 
Tromethamine
 
C4H11NO3
 
6503 
Moderate    Inter Info   
[3], [4], [1], [5], [6]
      Pharmacodynamic additive effects
   Increased risk of other adverse reactions (Unspecific) Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1513
 
Sulfadiazine
 
C10H10N4O2S
 
5215 
Major    Inter Info   
[1], [2]
D1514
 
Sulfadoxine
 
C12H14N4O4S
 
17134 
Major    Inter Info   
[1], [2]
D1515
 
Sulfamethizole
 
C9H10N4O2S2
 
5328 
Major    Inter Info   
[1], [2]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Major    Inter Info   
[1], [2]
D1517
 
Sulfasalazine
 
C18H14N4O5S
 
5339 
Major    Inter Info   
[1], [2]
D1519
 
Sulfisoxazole
 
C11H13N3O3S
 
5344 
Major    Inter Info   
[1], [2]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[11], [12], [13]
References
1 Product Information. Hiprex (methenamine). Hoechst Marion-Roussel Inc, Kansas City, MO.
2 Product Information. Urised (methenamine). Polymedica Pharmaceuticals USA Inc, Woburn, MA.
3 Kevorkian C, Merritt J, Ilstrup D "Methenamine mandelate with acidification: an effective urinary antiseptic in patients with neurogenic bladder." Mayo Clin Proc 59 (1984): 523. [PMID: 6379319]
4 Musher D, Griffith D "Generation of formaldehyde from methenamine: effect of pH and concentration, and antibacterial effect." Antimicrob Agents Chemother 6 (1974): 708-11. [PMID: 4451344]
5 Product Information. Hyophen (benzoic acid/hyoscy/methen/mblue/phenylsal). BioComp Pharma, San Antonio, TX.
6 Sand TE, Jacobsen S "Effect of urine pH and flow on renal clearance of methotrexate." Eur J Clin Pharmacol 19 (1981): 453-6. [PMID: 7250179]
7 Beckett AH, Rowland M, Turner P "Influence of urinary pH on excretion of amphetamine." Lancet 1 (1965): 303. [PMID: 14247879]
8 Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
9 Gary NE, Saidi P "Methamphetamine intoxication. A speedy new treatment." Am J Med 64 (1978): 537-40
10 Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
11 Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
12 MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
13 Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.