Drug General Information (ID: DDI0A3X8VP)
Drug Name			Nicotine		Drug Info		Ergotamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Smoking Cessation Agents				Analgesics
Structure

Mechanism of Nicotine-Ergotamine Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Nicotine				Ergotamine
Mechanism		Potentiate the ischemic response to ergot alkaloid				Ergot alkaloid
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Nicotine and Ergotamine

Recommended Action
Management		Caution may be advisable when ergot alkaloids are used in combination with nicotine products. Patients should be advised to seek immediate medical attention if they experience potential symptoms of ischemia such as coldness, pallor, cyanosis, numbness, tingling, or pain in the extremities muscle weakness severe or worsening headache visual disturbances severe abdominal pain chest pain and shortness of breath.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.