Details of Drug

Details of Drug

 Drug General Information (ID: D0593)
  Drug Name
Ergotamine
  Drug Type Small molecule
  Drug Synonymous
Avetol; Cornutamin; Cornutamine; ETIN; Ergam; Ergate; Ergomar; Ergonsvine; Ergostat; Ergotamin; Ergotartrate; Exmigra; Femergin;Gynergen; Lingraine; Lingran; Migretamine; Rigetamin; Secagyn; Secupan; Temigran; Wigrettes; Ergotamine bitartrate; Ergotamine hemitartrate; Ergotamine tartrate; Gotamine tartrate; Medihaler ergotamine; Ergomar (TN); Ergotamina [INN-Spanish]; Ergotamine (INN); Ergotamine [INN:BAN]; Ergotamine tartrate (VAN); Ergotaminum [INN-Latin]; Ergoton-A; Neo-ergotin; Ergotamine, tartrate (2:1); Ergotamine tartrate, Avetol, Cornutamin, Ergam, Ergotartrate; ERGOTAMINE (SEE ALSO: ERGOTAMINE TARTRATE (CAS 379-79-3)); Ergotamine, tartrate (2:1) (salt) (8CI); Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'-alpha)-(9CI); Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5alpha)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1); Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) (salt); (5'A)-5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxoergotaman 2,3-dihydroxybutanedioate(2:1); 12'-Hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione
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  Disease Class 8A80-8A84: Headache
  Therapeutic Class Analgesics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C33H35N5O5
  InChI 1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39)/t21-,25-,26+,27+,32-,33+/m1/s1
  InChIKey XCGSFFUVFURLIX-VFGNJEKYSA-N
  Canonical SMILES CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C
  External Link
Pubchem ID 8223
CAS Number 379-79-3
CHEBI ID 64318
TTD ID D01TSI
VARIDT ID DR00500

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM024  Competitive inhibition of metabolic enzyme
BM041  Additive hypertensive effects
BM046  Additive serotonergic effects
BM078  Increased risk of rapid heart rate
BM083  Potentiated the pharmacological effects (Unspecific)
BM089  Antagonize the effect of antihypertensive agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Ergotamine
      Affected cellular transport
   Transporter inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[208]
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Major    Inter Info   
[150]
D1821
 
Iobenguane (I-123)
 
C8H10IN3
 
60860 
Moderate    Inter Info   
[23], [191], [209]
D1825
 
Ioflupane I-123
 
C18H23FINO2
 
3086674 
Moderate    Inter Info   
[23], [191], [210]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  76
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Major    Inter Info   
[105]
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[137], [138], [110], [111], [113], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [145], [126], [132], [133], [134], [135], [136], [146]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Major    Inter Info   
[137], [138], [113], [139], [114], [140], [141], [142], [143], [144], [147], [121], [63], [126], [134], [146]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Major    Inter Info   
[137], [138], [110], [111], [113], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [145], [126], [132], [133], [134], [135], [136], [146]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Major    Inter Info   
[137], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [148], [132], [133], [134], [135], [136], [146]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Major    Inter Info   
[137], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [149], [132], [133], [134], [135], [136], [146]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Major    Inter Info   
[137], [138], [110], [111], [113], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [145], [126], [132], [133], [134], [135], [136], [146]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Major    Inter Info   
[137], [138], [110], [111], [188], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [189], [190], [132], [133], [134], [135], [136], [146]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Major    Inter Info   
[137], [138], [110], [111], [188], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [189], [190], [132], [133], [134], [135], [136], [146]
D0906
 
Letermovir
 
C29H28F4N4O4
 
45138674 
Major    Inter Info   
[137], [138], [110], [111], [113], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [145], [126], [132], [133], [134], [135], [136], [146]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Major    Inter Info   
[137], [138], [110], [111], [113], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [145], [126], [132], [133], [134], [135], [136], [146]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Major    Inter Info   
[196], [197], [198]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Major    Inter Info   
[137], [138], [110], [111], [113], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [145], [126], [199], [132], [133], [134], [135], [136], [146]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Major    Inter Info   
[137], [138], [110], [111], [188], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [189], [190], [132], [133], [134], [135], [136], [146]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Major    Inter Info   
[137], [138], [110], [111], [113], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [145], [126], [132], [133], [134], [135], [136], [146]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Major    Inter Info   
[137], [138], [113], [139], [114], [140], [141], [142], [143], [144], [147], [121], [63], [126], [134], [146]
D0799
 
Indinavir
 
C36H47N5O4
 
5362440 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Major    Inter Info   
[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [63], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Major    Inter Info   
[137], [138], [110], [111], [188], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [189], [190], [132], [133], [134], [135], [136], [146]
D0069
 
Amlodipine
 
C20H25ClN2O5
 
2162 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0100
 
Aprepitant
 
C23H21F7N4O3
 
135413536 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0139
 
Azithromycin
 
C38H72N2O12
 
447043 
Moderate    Inter Info   
[137], [138], [113], [139], [114], [140], [141], [142], [143], [144], [147], [121], [63], [126], [146]
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0367
 
Clotrimazole
 
C22H17ClN2
 
2812 
Moderate    Inter Info   
[137], [138], [111], [139], [114], [140], [141], [142], [143], [116], [144], [118], [63], [126], [201], [132], [133], [134], [136]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[202]
D0007
 
Abiraterone
 
C24H31NO
 
132971 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0180
 
Bicalutamide
 
C18H14F4N2O4S
 
2375 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0416
 
Danazol
 
C22H27NO2
 
28417 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0693
 
Fosaprepitant
 
C23H22F7N4O6P
 
135413538 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0696
 
Fosnetupitant
 
C31H35F6N4O5P
 
71544786 
Moderate    Inter Info   
[140], [142], [133]
D0735
 
Goldenseal
 
NA
 
NA
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0858
 
Isoniazid
 
C6H7N3O
 
3767 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[212]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[140], [142], [133]
D0911
 
Levamlodipine
 
C20H25ClN2O5
 
9822750 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0944
 
Lomitapide
 
C39H37F6N3O2
 
9853053 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1127
 
Netupitant
 
C30H32F6N4O
 
6451149 
Moderate    Inter Info   
[140], [142], [133]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1214
 
Palbociclib
 
C24H29N7O2
 
5330286 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1230
 
Pasireotide
 
C58H66N10O9
 
9941444 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[188], [113], [219]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Moderate    Inter Info   
[222]
D1524
 
Suvorexant
 
C23H23ClN6O2
 
24965990 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1709
 
Voxelotor
 
C19H19N3O3
 
71602803 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[137], [138], [111], [139], [114], [140], [141], [142], [143], [116], [144], [118], [63], [126], [201], [132], [133], [134], [136]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1714
 
Zafirlukast
 
C31H33N3O6S
 
5717 
Moderate    Inter Info   
[137], [109], [138], [110], [111], [139], [114], [140], [141], [142], [143], [115], [116], [144], [118], [119], [121], [63], [126], [132], [133], [134], [135], [136], [146]
D1394
 
Retapamulin (topical)
 
C30H47NO4S
 
6918462 
Minor    Inter Info   
[223]
   CYP450 enzyme induction Drug Num:  54
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0061
 
Aminoglutethimide
 
C13H16N2O2
 
2145 
Moderate    Inter Info   
[188], [113], [145]
D0178
 
Bexarotene
 
C24H28O2
 
82146 
Moderate    Inter Info   
[188], [113], [145]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[188], [113], [145]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[188], [113], [145]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[188], [113], [145]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[188], [113], [145]
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[188], [113], [145]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[188], [113], [145]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Moderate    Inter Info   
[188], [113], [145]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[188], [113], [145]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[188], [113], [145]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[113], [205]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[188], [113], [145]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[188], [113], [145]
D0518
 
Doravirine
 
C17H11ClF3N5O3
 
58460047 
Moderate    Inter Info   
[188], [113], [145]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[188], [206]
D0555
 
Elagolix
 
C32H30F5N3O5
 
11250647 
Moderate    Inter Info   
[188], [113], [145]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[207]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[188], [113], [145]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[188], [113], [145]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Moderate    Inter Info   
[188], [113], [145]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[188], [113], [145]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[188], [113], [145]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[188], [113], [145]
D0905
 
Lesinurad
 
C17H14BrN3O2S
 
53465279 
Moderate    Inter Info   
[188], [113], [145]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[213]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[188], [113], [145]
D1050
 
Metreleptin
 
NA
 
NA
Moderate    Inter Info   
[188], [113], [145]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Moderate    Inter Info   
[188], [113], [145]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Moderate    Inter Info   
[113], [214]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[188], [113], [145]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Moderate    Inter Info   
[188], [113], [145]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[188], [113], [145]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[188], [113], [145]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[188], [113], [145]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[188], [113], [145]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Moderate    Inter Info   
[188], [113], [145]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Moderate    Inter Info   
[188], [113], [145]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[188], [113], [145]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[188], [113], [145]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[188], [113], [145]
D1502
 
St. John's Wort
 
NA
 
NA
Moderate    Inter Info   
[188], [113], [145]
D1538
 
Tazemetostat
 
C34H44N4O4
 
66558664 
Moderate    Inter Info   
[188], [113], [145]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[188], [113], [145]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[188], [113], [145]
D0741
 
Griseofulvin
 
C17H17ClO6
 
441140 
Moderate    Inter Info   
[188], [113], [145]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Moderate    Inter Info   
[188], [113], [145]
D1099
 
Nafcillin
 
C21H22N2O5S
 
8982 
Moderate    Inter Info   
[188], [113], [145]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[188], [113], [145]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[188], [113], [145]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[188], [113], [145]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[188], [113], [145]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[188], [113], [145]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[188], [113], [145]
   Competitive inhibition of metabolic enzyme Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Moderate    Inter Info   
[220], [221]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Moderate    Inter Info   
[220], [221]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Moderate    Inter Info   
[220], [221]
      Pharmacodynamic additive effects
   Additive hypertensive effects Drug Num:  50
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0505
 
Dipivefrin (ophthalmic)
 
C19H29NO5
 
3105 
Major    Inter Info   
[103], [63], [104]
D0581
 
Epinephrine
 
C9H13NO3
 
5816 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D0582
 
Epinephrine (ophthalmic)
 
C9H13NO3
 
5816 
Major    Inter Info   
[103], [63], [104]
D0583
 
Epinephrine (topical)
 
C9H13NO3
 
5816 
Major    Inter Info   
[103], [63], [104]
D0517
 
Dopamine
 
C8H11NO2
 
681 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D0579
 
Ephedrine
 
C10H15NO
 
9294 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D0580
 
Ephedrine (nasal)
 
C10H15NO
 
9294 
Major    Inter Info   
[103], [63], [104]
D0857
 
Isometheptene
 
C9H19N
 
22297 
Major    Inter Info   
[103], [63], [104]
D0913
 
Levmetamfetamine (nasal)
 
C10H15N
 
36604 
Major    Inter Info   
[103], [63], [104]
D0921
 
Levonordefrin
 
C9H13NO3
 
164739 
Major    Inter Info   
[103], [63], [104]
D1002
 
Mephentermine
 
C11H17N
 
3677 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D1027
 
Methoxamine
 
C11H17NO3
 
6082 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D1107
 
Naphazoline (nasal)
 
C14H14N2
 
4436 
Major    Inter Info   
[103], [63], [104]
D1108
 
Naphazoline (ophthalmic)
 
C14H14N2
 
4436 
Major    Inter Info   
[103], [63], [104]
D1204
 
Oxymetazoline (nasal)
 
C16H24N2O
 
4636 
Major    Inter Info   
[103], [63], [104]
D1205
 
Oxymetazoline (ophthalmic)
 
C16H24N2O
 
4636 
Major    Inter Info   
[103], [63], [104]
D1206
 
Oxymetazoline (topical)
 
C16H24N2O
 
4636 
Major    Inter Info   
[103], [63], [104]
D1358
 
Propylhexedrine (nasal)
 
C10H21N
 
7558 
Major    Inter Info   
[103], [63], [104]
D1363
 
Pseudoephedrine
 
C10H15NO
 
7028 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D1567
 
Tetryzoline (nasal)
 
C13H16N2
 
5419 
Major    Inter Info   
[103], [63], [104]
D1568
 
Tetryzoline (ophthalmic)
 
C13H16N2
 
5419 
Major    Inter Info   
[103], [63], [104]
D1712
 
Xylometazoline (nasal)
 
C16H24N2
 
5709 
Major    Inter Info   
[103], [63], [104]
D1013
 
Metaraminol
 
C9H13NO2
 
5906 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D1061
 
Midodrine
 
C12H18N2O4
 
4195 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D1153
 
Norepinephrine
 
C8H11NO3
 
439260 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D1276
 
Phenylephrine
 
C9H13NO2
 
6041 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D1277
 
Phenylephrine (nasal)
 
C9H13NO2
 
6041 
Major    Inter Info   
[103], [63], [104]
D1278
 
Phenylephrine (ophthalmic)
 
C9H13NO2
 
6041 
Major    Inter Info   
[103], [63], [104]
D1280
 
Phenylephrine (topical)
 
C9H13NO2
 
6041 
Major    Inter Info   
[103], [63], [104]
D1281
 
Phenylpropanolamine
 
C9H13NO
 
26934 
Major    Inter Info   
[103], [106], [107], [108], [63], [104]
D0117
 
Atenolol
 
C14H22N2O3
 
2249 
Moderate    Inter Info   
[121], [126], [200]
D0173
 
Betaxolol
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[121], [126], [200]
D0174
 
Betaxolol (ophthalmic)
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[121], [126], [200]
D0188
 
Bisoprolol
 
C18H31NO4
 
2405 
Moderate    Inter Info   
[121], [126], [200]
D0265
 
Carteolol
 
C16H24N2O3
 
2583 
Moderate    Inter Info   
[121], [126], [200]
D0010
 
Acebutolol
 
C18H28N2O4
 
1978 
Moderate    Inter Info   
[121], [126], [200]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Moderate    Inter Info   
[121], [126], [200]
D0879
 
Ketamine
 
C13H16ClNO
 
3821 
Moderate    Inter Info   
[188], [113], [211]
D0914
 
Levobetaxolol (ophthalmic)
 
C18H29NO3
 
60657 
Moderate    Inter Info   
[121], [126], [200]
D0915
 
Levobunolol (ophthalmic)
 
C17H25NO3
 
39468 
Moderate    Inter Info   
[121], [126], [200]
D1045
 
Metipranolol (ophthalmic)
 
C17H27NO4
 
31477 
Moderate    Inter Info   
[121], [126], [200]
D1098
 
Nadolol
 
C17H27NO4
 
39147 
Moderate    Inter Info   
[121], [126], [200]
D1114
 
Nebivolol
 
C22H25F2NO4
 
71301 
Moderate    Inter Info   
[121], [126], [200]
D1244
 
Penbutolol
 
C18H29NO2
 
37464 
Moderate    Inter Info   
[121], [126], [200]
D1293
 
Pindolol
 
C14H20N2O2
 
4828 
Moderate    Inter Info   
[121], [126], [200]
D0602
 
Esmolol
 
C16H25NO4
 
59768 
Moderate    Inter Info   
[121], [126], [200]
D1049
 
Metoprolol
 
C15H25NO3
 
4171 
Moderate    Inter Info   
[121], [126], [200]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Moderate    Inter Info   
[121], [126], [200]
D1585
 
Timolol
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[121], [126], [200]
D1586
 
Timolol (ophthalmic)
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[121], [126], [200]
   Additive serotonergic effects Drug Num:  29
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0457
 
Dexfenfluramine
 
C12H16F3N
 
66265 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Major    Inter Info   
[151], [152], [153], [154], [155], [156], [157], [158], [8], [11], [159], [160], [161], [162], [163], [17], [19], [164], [165], [166], [167], [168], [169], [170], [171], [172], [45], [47], [49], [50], [54], [173], [174], [175], [62], [63], [64], [65], [176], [75], [77], [78], [177], [178], [179], [180], [181], [182], [91], [183], [184], [185], [186], [187]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Major    Inter Info   
[191], [192], [193]
D0920
 
Levomilnacipran
 
C15H22N2O
 
6917779 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1036
 
Methylene blue
 
C16H18ClN3S
 
6099 
Major    Inter Info   
[151], [152], [153], [154], [155], [156], [157], [158], [8], [11], [159], [160], [161], [162], [163], [17], [19], [164], [165], [166], [167], [168], [169], [170], [171], [172], [45], [47], [49], [50], [54], [173], [174], [175], [62], [63], [64], [65], [176], [75], [77], [78], [177], [178], [179], [180], [181], [182], [91], [183], [184], [185], [186], [187]
D1066
 
Milnacipran
 
C15H22N2O
 
65833 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [188], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1229
 
Paroxetine
 
C19H20FNO3
 
43815 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Major    Inter Info   
[151], [152], [153], [154], [155], [156], [157], [158], [8], [11], [159], [160], [161], [162], [163], [17], [19], [164], [165], [166], [167], [168], [169], [170], [171], [172], [45], [47], [49], [50], [54], [173], [174], [175], [62], [63], [64], [65], [176], [75], [77], [78], [177], [178], [179], [180], [181], [182], [91], [183], [184], [185], [186], [187]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Major    Inter Info   
[151], [152], [153], [154], [155], [156], [157], [158], [8], [11], [159], [160], [161], [162], [163], [17], [19], [164], [165], [166], [167], [168], [169], [170], [171], [172], [45], [47], [49], [50], [54], [173], [174], [175], [62], [63], [64], [65], [176], [75], [77], [78], [177], [178], [179], [180], [181], [182], [91], [183], [184], [185], [186], [187]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Major    Inter Info   
[151], [152], [153], [154], [155], [156], [157], [158], [8], [11], [159], [160], [161], [162], [163], [17], [19], [164], [165], [166], [167], [168], [169], [170], [171], [172], [45], [47], [49], [50], [54], [173], [174], [175], [62], [63], [64], [65], [176], [75], [77], [78], [177], [178], [179], [180], [181], [182], [91], [183], [184], [185], [186], [187]
D1437
 
Safinamide
 
C17H19FN2O2
 
131682 
Major    Inter Info   
[151], [152], [153], [154], [155], [156], [157], [158], [8], [11], [159], [160], [161], [162], [163], [17], [19], [164], [165], [166], [167], [168], [169], [170], [171], [172], [45], [47], [49], [50], [54], [173], [174], [175], [62], [63], [64], [65], [176], [75], [77], [78], [177], [178], [179], [180], [181], [182], [91], [183], [184], [185], [186], [187]
D1455
 
Selegiline
 
C13H17N
 
26757 
Major    Inter Info   
[151], [152], [153], [154], [155], [156], [157], [158], [8], [11], [159], [160], [161], [162], [163], [17], [19], [164], [165], [166], [167], [168], [169], [170], [171], [172], [45], [47], [49], [50], [54], [173], [174], [175], [62], [63], [64], [65], [176], [75], [77], [78], [177], [178], [179], [180], [181], [182], [91], [183], [184], [185], [186], [187]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Major    Inter Info   
[8], [21], [23], [31], [45], [50], [54], [71], [91]
D1535
 
Tapentadol
 
C14H23NO
 
9838022 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Major    Inter Info   
[151], [152], [153], [154], [155], [156], [157], [158], [8], [11], [159], [160], [161], [162], [163], [17], [19], [164], [165], [166], [167], [168], [169], [170], [171], [172], [45], [47], [49], [50], [54], [173], [174], [175], [62], [63], [64], [65], [176], [75], [77], [78], [177], [178], [179], [180], [181], [182], [91], [183], [184], [185], [186], [187]
D1696
 
Vilazodone
 
C26H27N5O2
 
6918314 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1708
 
Vortioxetine
 
C18H22N2S
 
9966051 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0641
 
Fenfluramine
 
C12H16F3N
 
3337 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1075
 
Mirtazapine
 
C17H19N3
 
4205 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1624
 
Trazodone
 
C19H22ClN5O
 
5533 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[151], [152], [153], [154], [155], [156], [157], [158], [8], [9], [10], [11], [159], [160], [161], [162], [163], [17], [215], [19], [164], [165], [166], [167], [168], [169], [170], [216], [171], [172], [45], [47], [49], [50], [54], [58], [173], [174], [175], [60], [61], [62], [63], [64], [65], [67], [68], [69], [176], [70], [74], [75], [76], [77], [78], [217], [79], [80], [177], [86], [178], [179], [180], [181], [182], [91], [218], [183], [184], [185], [186], [187]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1133
 
Nicotine
 
C10H14N2
 
89594 
Moderate    Inter Info   
[188], [113], [126]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  13
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0494
 
Dihydroergotamine
 
C33H37N5O5
 
10531 
Major    Inter Info   
[100], [101], [102]
D0557
 
Eletriptan
 
C22H26N2O2S
 
77993 
Major    Inter Info   
[100], [101], [102]
D0041
 
Almotriptan
 
C17H25N3O2S
 
123606 
Major    Inter Info   
[100], [101], [102]
D0212
 
Bromocriptine
 
C32H40BrN5O5
 
31101 
Major    Inter Info   
[100], [101], [102]
D0592
 
Ergometrine
 
C19H23N3O2
 
443884 
Major    Inter Info   
[100], [101], [102]
D0702
 
Frovatriptan
 
C14H17N3O
 
77992 
Major    Inter Info   
[100], [101], [102]
D0952
 
Lorcaserin
 
C11H14ClN
 
11658860 
Major    Inter Info   
[194], [191], [195]
D1110
 
Naratriptan
 
C17H25N3O2S
 
4440 
Major    Inter Info   
[100], [101], [102]
D1419
 
Rizatriptan
 
C15H19N5
 
5078 
Major    Inter Info   
[100], [101], [102]
D1037
 
Methylergometrine
 
C20H25N3O2
 
8226 
Major    Inter Info   
[100], [101], [102]
D1043
 
Methysergide
 
C21H27N3O2
 
9681 
Major    Inter Info   
[100], [101], [102]
D1521
 
Sumatriptan
 
C14H21N3O2S
 
5358 
Major    Inter Info   
[100], [101], [102]
D1728
 
Zolmitriptan
 
C16H21N3O2
 
60857 
Major    Inter Info   
[100], [101], [102]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0083
 
Amyl Nitrite
 
C5H11NO2
 
10026 
Moderate    Inter Info   
[63], [203], [204]
D0861
 
Isosorbide dinitrate
 
C6H8N2O8
 
6883 
Moderate    Inter Info   
[63], [203], [204]
D0862
 
Isosorbide mononitrate
 
C6H9NO6
 
27661 
Moderate    Inter Info   
[63], [203], [204]
D1146
 
Nitroglycerin
 
C3H5N3O9
 
4510 
Moderate    Inter Info   
[63], [203], [204]
References
1 Achamallah NS "Visual hallucinations after combining fluoxetine and dextromethorphan ." Am J Psychiatry 149 (1992): 1406. [PMID: 1530079]
2 Ailawadhi S, Sung KW, Carlson LA, Baer MR "Serotonin syndrome caused by interaction between citalopram and fentanyl." J Clin Pharm Ther 32 (2007): 199-202. [PMID: 17381671]
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64 Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
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128 Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
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191 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
192 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
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198 Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
199 Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
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202 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
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208 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
209 Product Information. AdreView (iobenguane I-123). GE Healthcare, Princeton, NJ.
210 Product Information. DaTscan (ioflupane I-123). GE Healthcare, Princeton, NJ.
211 Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
212 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
213 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
214 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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219 Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
220 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
221 Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
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223 Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.