Details of Drug

Details of Drug

 Drug General Information (ID: D1133)
  Drug Name
Nicotine
  Drug Type Small molecule
  Drug Synonymous
Habitrol; Micotine; NCT; NICOTINE AND SALTS; Nicoderm Patch; Nicotina [Italian]; Nicotine Patch; Nicotine [USAN]; Nicotine replacement patch; Nicotine solution; Nictoine patch; Nikotin [German]; Nikotyna [Polish]; Transdermal Nicotine; Nicotine [UN1654] [Poison]; ENT 3,424; Habitrol (TN); Nicorette (TN); Nicotine (USP); Nicotine (compounds related to); Nicotine [BSI:ISO]; L(-)-nicotine; Beta-Pyridyl-alpha-N-methyl pyrrolidine; (-)-Nicotine solution; (2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine; (S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE; (S)-(-)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-3-(N-methylpyrrolidin-2-yl)pyridine; (S)-Nicotine; 3-(2-(N-methylpyrrolidinyl))pyridine; 3-(N-Methylpyrollidino)pyridine; 3-(N-Methylpyrrolidino)pyridine; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
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  Disease Class 6C4A: Nicotine use disorder
  Therapeutic Class Smoking Cessation Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C10H14N2
  InChI 1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
  InChIKey SNICXCGAKADSCV-JTQLQIEISA-N
  Canonical SMILES CN1CCCC1C2=CN=CC=C2
  External Link
Pubchem ID 89594
CAS Number 20033
CHEBI ID 17688
TTD ID D0T8GD
INTEDE ID DR1148
VARIDT ID DR00679

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM028  Competitive inhibition of renal tubular secretion
BM041  Additive hypertensive effects
BM083  Potentiated the pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Nicotine
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[1]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Moderate    Inter Info   
[4], [2], [10]
D0642
 
Fenofibrate
 
C20H21ClO4
 
3339 
Moderate    Inter Info   
[4], [2], [11]
   CYP450 enzyme induction Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[2], [3]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[9]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[4], [12]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[2], [13]
      Affected excretion pathways
   Competitive inhibition of renal tubular secretion Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0998
 
Memantine
 
C12H21N
 
4054 
Minor    Inter Info   
[14], [15], [16]
      Pharmacodynamic additive effects
   Additive hypertensive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Moderate    Inter Info   
[6], [7], [8]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0212
 
Bromocriptine
 
C32H40BrN5O5
 
31101 
Moderate    Inter Info   
[4], [2], [5]
D0494
 
Dihydroergotamine
 
C33H37N5O5
 
10531 
Moderate    Inter Info   
[4], [2], [5]
D0592
 
Ergometrine
 
C19H23N3O2
 
443884 
Moderate    Inter Info   
[4], [2], [5]
D0593
 
Ergotamine
 
C33H35N5O5
 
8223 
Moderate    Inter Info   
[4], [2], [5]
D1037
 
Methylergometrine
 
C20H25N3O2
 
8226 
Moderate    Inter Info   
[4], [2], [5]
D1043
 
Methysergide
 
C21H27N3O2
 
9681 
Moderate    Inter Info   
[4], [2], [5]
References
1 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
4 Cerner Multum, Inc. "Australian Product Information.".
5 Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
6 Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
7 Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
8 Posner J, Bye A, Jeal S, Peck AW, Whiteman P "Alcohol and bupropion pharmacokinetics in healthy male volunteers." Eur J Clin Pharmacol 26 (1984): 627-30
9 Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
10 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
11 Product Information. Antara (fenofibrate). Lupin Pharmaceuticals Inc, Baltimore, MD.
12 Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
13 Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
14 Ace LN, Jaffe JM, Kunka RL "Effect of food and an antacid on quinidine bioavailability." Biopharm Drug Dispos 4 (1983): 183-90. [PMID: 6882885]
15 Min DI, Ku YM, Geraets DR, Lee HC "Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers." J Clin Pharmacol 36 (1996): 469-76. [PMID: 8739026]
16 Product Information. Namenda (memantine). Forest Pharmaceuticals, St. Louis, MO.