Drug General Information (ID: DDIFBRSPXO)
Drug Name			Nicotine		Drug Info		Bupropion		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Smoking Cessation Agents				Antidepressants
Structure

Mechanism of Nicotine-Bupropion Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Nicotine				Bupropion
Mechanism		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Nicotine and Bupropion

Recommended Action
Management		Blood pressure monitoring is recommended for patients concomitantly using bupropion and nicotine replacement for smoking cessation.

References
1	Product Information. Wellbutrin (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
2	Product Information. Zyban (bupropion). Glaxo Wellcome, Research Triangle Park, NC.
3	Posner J, Bye A, Jeal S, Peck AW, Whiteman P "Alcohol and bupropion pharmacokinetics in healthy male volunteers." Eur J Clin Pharmacol 26 (1984): 627-30