Details of Drug

Details of Drug

 Drug General Information (ID: D1862)
  Drug Name
Pegvisomant
  Drug Type Hormones
  Drug Synonymous
Somavent; Pegvisomant (genetical recombination); Somavent (TN); Somavert (TN); Pegvisomant (USAN/INN); Pegvisomant (genetical recombination) (JAN)
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  Disease Class 5A60-5A61: Pituitary gland disorder
  Therapeutic Class Anabolic Agents
  External Link
TTD ID D0D6VE

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM048  Increased risk of angioedema/anaphylactoid reactions
BM064  Increased risk of hypoglycemia
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Pegvisomant
      Pharmacodynamic additive effects
   Increased risk of angioedema/anaphylactoid reactions Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1861
 
Pegvaliase
 
C15H30N2O5
 
86278362 
Moderate    Inter Info   
[7]
   Increased risk of hypoglycemia Drug Num:  44
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Moderate    Inter Info   
[1], [2], [3]
D0813
 
Insulin human
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0816
 
Insulin human (regular)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0819
 
Insulin lispro
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[1], [2], [3]
D0820
 
Insulin lispro (protamine)
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[1], [2], [3]
D0009
 
Acarbose
 
C25H43NO18
 
41774 
Moderate    Inter Info   
[1], [2], [3]
D0013
 
Acetohexamide
 
C15H20N2O4S
 
1989 
Moderate    Inter Info   
[1], [2], [3]
D0029
 
Albiglutide
 
C148H224N40O45
 
145994868 
Moderate    Inter Info   
[1], [2], [3]
D0042
 
Alogliptin
 
C18H21N5O2
 
11450633 
Moderate    Inter Info   
[1], [2], [3]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[1], [2], [3]
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Moderate    Inter Info   
[1], [2], [3]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[1], [2], [3]
D1779
 
Dulaglutide
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[1], [2], [3]
D1782
 
Ertugliflozin
 
C22H25ClO7
 
44814423 
Moderate    Inter Info   
[1], [2], [3]
D1784
 
Exenatide
 
C184H282N50O60S
 
45588096 
Moderate    Inter Info   
[1], [2], [3]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Moderate    Inter Info   
[1], [2], [3]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Moderate    Inter Info   
[1], [2], [3]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Moderate    Inter Info   
[1], [2], [3]
D0807
 
Insulin aspart (aspart protamine)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[1], [2], [3]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[1], [2], [3]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Moderate    Inter Info   
[1], [2], [3]
D0810
 
Insulin detemir
 
C267H402N64O76S6
 
16137271 
Moderate    Inter Info   
[1], [2], [3]
D0812
 
Insulin glulisine
 
C258H384N64O78S6
 
16136701 
Moderate    Inter Info   
[1], [2], [3]
D0930
 
Linagliptin
 
C25H28N8O2
 
10096344 
Moderate    Inter Info   
[1], [2], [3]
D0936
 
Liraglutide
 
C172H265N43O51
 
16134956 
Moderate    Inter Info   
[1], [2], [3]
D0941
 
Lixisenatide
 
C215H347N61O65S
 
90472060 
Moderate    Inter Info   
[1], [2], [3]
D1015
 
Metformin
 
C4H11N5
 
4091 
Moderate    Inter Info   
[1], [2], [3]
D1064
 
Miglitol
 
C8H17NO5
 
441314 
Moderate    Inter Info   
[1], [2], [3]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Moderate    Inter Info   
[1], [2], [3]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Moderate    Inter Info   
[1], [2], [3]
D1326
 
Pramlintide
 
C171H267N51O53S2
 
70691388 
Moderate    Inter Info   
[1], [2], [3]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[1], [2], [3]
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Moderate    Inter Info   
[1], [2], [3]
D1449
 
Saxagliptin
 
C18H25N3O2
 
11243969 
Moderate    Inter Info   
[1], [2], [3]
D1887
 
Semaglutide
 
C187H291N45O59
 
56843331 
Moderate    Inter Info   
[1], [2], [3]
D1477
 
Sitagliptin
 
C16H15F6N5O
 
4369359 
Moderate    Inter Info   
[1], [2], [3]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Moderate    Inter Info   
[1], [2], [3]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Moderate    Inter Info   
[1], [2], [3]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  28
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0035
 
Alfentanil
 
C21H32N6O3
 
51263 
Moderate    Inter Info   
[4], [5], [3]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[4], [5], [3]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[4], [5], [3]
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Moderate    Inter Info   
[4], [5], [3]
D0379
 
Codeine
 
C18H21NO3
 
5284371 
Moderate    Inter Info   
[4], [5], [3]
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Moderate    Inter Info   
[4], [5], [3]
D0470
 
Dezocine
 
C16H23NO
 
3033053 
Moderate    Inter Info   
[4], [5], [3]
D0493
 
Dihydrocodeine
 
C18H23NO3
 
5284543 
Moderate    Inter Info   
[4], [5], [3]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Moderate    Inter Info   
[4], [5], [3]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[4], [5], [3]
D0776
 
Hydromorphone
 
C17H19NO3
 
5284570 
Moderate    Inter Info   
[4], [5], [3]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Moderate    Inter Info   
[4], [5], [3]
D0923
 
Levorphanol
 
C17H23NO
 
5359272 
Moderate    Inter Info   
[4], [5], [3]
D1001
 
Meperidine
 
C15H21NO2
 
4058 
Moderate    Inter Info   
[4], [5], [3]
D1017
 
Methadone
 
C21H27NO
 
4095 
Moderate    Inter Info   
[4], [5], [3]
D1089
 
Morphine
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[4], [5], [3]
D1090
 
Morphine (liposomal)
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[4], [5], [3]
D1100
 
Nalbuphine
 
C21H27NO4
 
5311304 
Moderate    Inter Info   
[4], [5], [3]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Moderate    Inter Info   
[4], [5], [3]
D1183
 
Opium
 
NA
 
NA
Moderate    Inter Info   
[4], [5], [3]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Moderate    Inter Info   
[4], [5], [3]
D1208
 
Oxymorphone
 
C17H19NO4
 
5284604 
Moderate    Inter Info   
[4], [5], [3]
D1860
 
Pegloticase
 
NA
 
NA
Moderate    Inter Info   
[6]
D1247
 
Pentazocine
 
C19H27NO
 
441278 
Moderate    Inter Info   
[4], [5], [3]
D1390
 
Remifentanil
 
C20H28N2O5
 
60815 
Moderate    Inter Info   
[4], [5], [3]
D1512
 
Sufentanil
 
C22H30N2O2S
 
41693 
Moderate    Inter Info   
[4], [5], [3]
D1535
 
Tapentadol
 
C14H23NO
 
9838022 
Moderate    Inter Info   
[4], [5], [3]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Moderate    Inter Info   
[4], [5], [3]
References
1 Jerntorp P, Almer LO "Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy in non-insulin dependent diabetes." Acta Med Scand 656 (1981): 33-6. [PMID: 6953748]
2 Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
3 Product Information. Somavert (pegvisomant). Pharmacia and Upjohn, Kalamazoo, MI.
4 Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
5 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
6 Product Information. Krystexxa (pegloticase). Savient Pharmaceuticals, East Brunswick, NJ.
7 Product Information. Palynziq (pegvaliase). BioMarin Pharmaceutical Inc, Novato, CA.