Drug General Information (ID: DDIRA6CYNP)
Drug Name			Pegvisomant		Drug Info		Opium		Drug Info
Drug Type		Hormones				Small molecule
Therapeutic Class		Anabolic Agents				Narcotic Analgesics

Mechanism of Pegvisomant-Opium Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Pegvisomant				Opium
Mechanism		Pegvisomant				Reduced pharmacological effects of pegvisomant
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Pegvisomant when combined with Opium

Recommended Action
Management		Clinicians should be aware of this potential interaction and adjust the dosage of pegvisomant appropriately in patients treated with opioids.

References
1	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
2	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
3	Product Information. Somavert (pegvisomant). Pharmacia and Upjohn, Kalamazoo, MI.