Details of Drug

Details of Drug

 Drug General Information (ID: D1785)
  Drug Name
Flumazenil
  Drug Type Small molecule
  Drug Synonymous
flumazenil; 78755-81-4; Anexate; Flumazepil; Romazicon; Lanexat; Mazicon; Ro 15-1788; Flumazenilum; Flumazenilo; Flumazenilum [Latin]; Flumazenilo [Spanish]; Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate; [11C]flumazenil; Ro 151788; Flumazenil (Ro 15-1788); Ro-15-1788; UNII-40P7XK9392; C15H14FN3O3; CHEMBL407; Ro15-1788; BRN 4763661; MLS000028850; Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; CHEBI:5103; OFBIFZUFASYYRE-UHFFFAOYSA-N; FlumUP TD; Flumazenil (transdermal patch formulation); Flumazenil (transdermal patch formulation), Coeruleus
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  Disease Class PC91: Intentional self-harm
  Therapeutic Class Antidotes
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C15H14FN3O3
  InChI 1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
  InChIKey OFBIFZUFASYYRE-UHFFFAOYSA-N
  Canonical SMILES CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
  External Link
Pubchem ID 3373
CAS Number CAS 78755-81-4
CHEBI ID CHEBI:5103
TTD ID D0D5GD

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM069  Increased risk of lowers seizure threshold
BM087  Antagonize the effect of antiepileptic agents
  Relation Graph
 Full list of drugs interacting with Flumazenil
      Pharmacodynamic additive effects
   Increased risk of lowers seizure threshold Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Major    Inter Info   
[1], [2], [3]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Major    Inter Info   
[1], [2], [3]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Major    Inter Info   
[1], [2], [3]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Major    Inter Info   
[1], [2], [3]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Major    Inter Info   
[1], [2], [3]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Major    Inter Info   
[1], [2], [3]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Major    Inter Info   
[1], [2], [3]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Major    Inter Info   
[1], [2], [3]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Major    Inter Info   
[1], [2], [3]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Major    Inter Info   
[1], [2], [3]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antiepileptic agents Drug Num:  13
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[4], [5], [6]
D0317
 
Chlordiazepoxide
 
C16H14ClN3O
 
2712 
Moderate    Inter Info   
[4], [5], [6]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[4], [5], [6]
D0362
 
Clonazepam
 
C15H10ClN3O3
 
2802 
Moderate    Inter Info   
[4], [5], [6]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Moderate    Inter Info   
[4], [5], [6]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[4], [5], [6]
D0679
 
Flurazepam
 
C21H23ClFN3O
 
3393 
Moderate    Inter Info   
[4], [5], [6]
D0748
 
Halazepam
 
C17H12ClF3N2O
 
31640 
Moderate    Inter Info   
[4], [5], [6]
D0951
 
Lorazepam
 
C15H10Cl2N2O2
 
3958 
Moderate    Inter Info   
[4], [5], [6]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[4], [5], [6]
D1197
 
Oxazepam
 
C15H11ClN2O2
 
4616 
Moderate    Inter Info   
[4], [5], [6]
D1547
 
Temazepam
 
C16H13ClN2O2
 
5391 
Moderate    Inter Info   
[4], [5], [6]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[4], [5], [6]
References
1 Bodenham AR "Death after flumazenil." BMJ 299 (1989): 457.[PMID: 2507014]
2 Marchant B, Wray R, Leach A, Nama M "Flumazenil causing convulsions and ventricular tachycardia." BMJ 299 (1989): 860.[PMID: 2510872]
3 Mordel A, Winkler E, Almog S, Tirosh M, Ezra D "Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose." Crit Care Med 20 (1992): 1733-4.[PMID: 1458953]
4 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
5 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
6 Product Information. Romazicon (flumazenil). Roche Laboratories, Nutley, NJ.