Details of Drug-Drug Interaction
| Drug General Information (ID: DDI1XWTOQK) | |||||||||
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| Drug Name | Midazolam | Drug Info | Flumazenil | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Anxiolytics/Sedatives/Hypnotics | Antidotes | |||||||
| Structure | |||||||||
| Mechanism of Midazolam-Flumazenil Interaction (Severity Level: Moderate) | |||||||||
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| Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Midazolam | Flumazenil | |||||||
| Mechanism |
Antiepileptic agent Gamma-aminobutyric acid receptor Agonist |
Lower seizure threshold Gamma-aminobutyric acid receptor Antagonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gamma-aminobutyric acid receptor | Structure Sequence | |||||||
| Protein Family | Ligand-gated ion channel | ||||||||
| Protein Function |
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | The use of flumazenil is not recommended in patients with epilepsy who have been receiving long-term treatment with benzodiazepines. In addition, flumazenil is contraindicated in patients who have received a benzodiazepine to control potentially life-threatening conditions such as status epilepticus or increased intracranial pressure. Extreme caution, dose individualization, and close monitoring is recommended for other patients. Clinicians should be prepared to manage convulsions. Most seizures have been successfully managed with benzodiazepines, phenytoin, or barbiturates. | ||||||||