Details of Drug

Details of Drug

 Drug General Information (ID: D1668)
  Drug Name
Urea
  Drug Type Small molecule
  Drug Synonymous
carbamide; 57-13-6; Isourea; Carbonyldiamide; Ureophil; Carbonyldiamine; Carbamimidic acid; Pseudourea; Ureaphil; Urevert; Carbaderm; Alphadrate; Keratinamin; Calmurid; Aquadrate; Carbonyl diamide; Pastaron; Urepearl; Carbamide resin; Ultra Mide; Varioform ii; Aqua Care; Prespersion, 75 urea; carmol; basodexan; Harnstoff; Nutraplus; Mocovina; Urea solution; Supercel 3000; Aqua Care HP; Ureacin-20; Ureacin-40 Creme; Ureacin-10 lotion; Polyurea; Panafil; Onychomal; Hyanit; Caswell No. 902; Carbonyl Diamine; Mocovina [Czech]; Harnstoff [Ge
    Click to Show/Hide
  Disease Class DA24: Oesophagitis
  Therapeutic Class Topical Emollients
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula CH4N2O
  InChI 1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
  InChIKey XSQUKJJJFZCRTK-UHFFFAOYSA-N
  Canonical SMILES C(=O)(N)N
  External Link
Pubchem ID 1176
CAS Number 57-13-6
CHEBI ID 16199
TTD ID D02XBW
VARIDT ID DR00048

Drug-Drug Interaction Network
  Sunburst Graph
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM031  Increased renal excretion (Unspecific)
BM042  Additive hypotensive effects
BM067  Increased risk of hyponatremia
BM072  Increased risk of nephrotoxicity
BM083  Potentiated the pharmacological effects (Unspecific)
BM089  Antagonize the effect of antihypertensive agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Urea
      Affected excretion pathways
   Increased renal excretion (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Minor    Inter Info   
[233], [234], [235]
      Pharmacodynamic additive effects
   Additive hypotensive effects Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0644
 
Fenoldopam
 
C16H16ClNO3
 
3341 
Moderate    Inter Info   
[215], [216]
D1251
 
Pentoxifylline
 
C13H18N4O3
 
4740 
Moderate    Inter Info   
[220]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[57], [174], [221]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[57], [174], [221]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[57], [174], [221]
D0980
 
Maraviroc
 
C29H41F2N5O
 
3002977 
Moderate    Inter Info   
[226]
D1408
 
Riociguat
 
C20H19FN8O2
 
11304743 
Moderate    Inter Info   
[230]
D0711
 
Garlic
 
NA
 
NA
Minor    Inter Info   
[231], [232]
   Increased risk of hyponatremia Drug Num:  16
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D0449
 
Desmopressin
 
C46H64N14O12S2
 
5311065 
Moderate    Inter Info   
[57], [58], [59], [60], [61], [62], [63], [64], [47], [65], [66], [67], [68], [69], [35], [70], [71], [11], [72], [73], [36], [74], [75], [76], [77], [78], [79], [80], [81], [37], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [46], [44], [95], [96], [97], [98], [99], [100], [24], [27], [51], [101], [29], [102], [103], [104], [105], [106], [26], [107], [108], [109], [110], [7], [111], [112], [113], [114], [115], [116], [117], [118], [119], [39], [120], [121], [34], [40], [122], [123], [12], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [18], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [23], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [43], [172], [173], [174], [175], [176], [4], [177], [178], [179], [180], [181], [182], [183], [184], [185], [20], [186], [187], [188], [189], [190], [191], [31], [192], [193], [30], [194], [33], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [6], [210], [211]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Moderate    Inter Info   
[3], [4], [7]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[222]
D0920
 
Levomilnacipran
 
C15H22N2O
 
6917779 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D1066
 
Milnacipran
 
C15H22N2O
 
65833 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D1696
 
Vilazodone
 
C26H27N5O2
 
6918314 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D1708
 
Vortioxetine
 
C18H22N2S
 
9966051 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D1683
 
Vasopressin
 
C46H65N15O12S2
 
644077 
Moderate    Inter Info   
[57], [58], [59], [60], [61], [62], [63], [64], [47], [65], [66], [67], [68], [69], [35], [70], [71], [11], [72], [73], [36], [74], [75], [76], [77], [78], [79], [80], [81], [37], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [46], [44], [95], [96], [97], [98], [99], [100], [24], [27], [51], [101], [29], [102], [103], [104], [105], [106], [26], [107], [108], [109], [110], [7], [111], [112], [113], [114], [115], [116], [117], [118], [119], [39], [120], [121], [34], [40], [122], [123], [12], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [18], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [23], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [43], [172], [173], [174], [175], [176], [4], [177], [178], [179], [180], [181], [182], [183], [184], [185], [20], [186], [187], [188], [189], [190], [191], [31], [192], [193], [30], [194], [33], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [6], [210], [211]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Moderate    Inter Info   
[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
   Increased risk of nephrotoxicity Drug Num:  9
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0472
 
Diatrizoate
 
C11H9I3N2O4
 
2140 
Moderate    Inter Info   
[212], [213], [214]
D0832
 
Iodixanol
 
C35H44I6N6O15
 
3724 
Moderate    Inter Info   
[212], [213], [214]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Moderate    Inter Info   
[212], [213], [214]
D0831
 
Iodipamide
 
C20H14I6N2O6
 
3739 
Moderate    Inter Info   
[212], [213], [214]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Moderate    Inter Info   
[212], [213], [214]
D0836
 
Iopromide
 
C18H24I3N3O8
 
3736 
Moderate    Inter Info   
[212], [213], [214]
D0837
 
Iothalamic acid
 
C11H9I3N2O4
 
3737 
Moderate    Inter Info   
[212], [213], [214]
D0838
 
Ioversol
 
C18H24I3N3O9
 
3741 
Moderate    Inter Info   
[212], [213], [214]
D0839
 
Ioxilan
 
C18H24I3N3O8
 
3743 
Moderate    Inter Info   
[212], [213], [214]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1777
 
Dinoprostone (topical)
 
C20H32O5
 
5280360 
Major    Inter Info   
[1], [2]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  14
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0888
 
Lactulose
 
C12H22O11
 
11333 
Moderate    Inter Info   
[217], [218], [219]
D0184
 
Bisacodyl
 
C22H19NO4
 
2391 
Moderate    Inter Info   
[217], [218], [219]
D0269
 
Castor oil
 
C57H104O9
 
14030006 
Moderate    Inter Info   
[217], [218], [219]
D0701
 
Frangula purshiana bark
 
NA
 
NA
Moderate    Inter Info   
[217], [218], [219]
D0731
 
Glycerin
 
C3H8O3
 
753 
Moderate    Inter Info   
[217], [218], [219]
D0887
 
Lactitol
 
C12H24O11
 
157355 
Moderate    Inter Info   
[217], [218], [219]
D0970
 
Magnesium citrate
 
C12H10Mg3O14
 
6099959 
Moderate    Inter Info   
[217], [218], [219]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[217], [218], [219]
D1069
 
Mineral oil
 
NA
 
NA
Moderate    Inter Info   
[217], [218], [219]
D1266
 
Phenolphthalein
 
C20H14O4
 
4764 
Moderate    Inter Info   
[217], [218], [219]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[227], [228], [229]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[227], [228], [229]
D1309
 
Polyethylene glycol (3350)
 
C2H6O2
 
174 
Moderate    Inter Info   
[217], [218], [219]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[227], [228], [229]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0926
 
Licorice
 
C42H62O16Zn
 
163463 
Moderate    Inter Info   
[223], [224], [225]
References
1 Product Information. Prostin E2 (dinoprostone topical). Pharmacia and Upjohn, Kalamazoo, MI.
2 Product Information. Prostin E2 Suppository (dinoprostone topical). Pharmacia and Upjohn, Kalamazoo, MI.
3 Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
4 Jackson C, Carson W, Markowitz J, Mintzer J "SIADH associated with fluoxetine and sertraline therapy." Am J Psychiatry 152 (1995): 809-10. [PMID: 7726326]
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6 Kessler J, Samuels SC "Sertraline and hyponatremia." N Engl J Med 335 (1996): 524. [PMID: 8676965]
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