Details of Drug

Details of Drug

 Drug General Information (ID: D1661)
  Drug Name
Turmeric
  Drug Type Small molecule
  Drug Synonymous
curcumin; 458-37-7; Diferuloylmethane; Natural yellow 3; Turmeric yellow; Turmeric; Curcuma; Kacha haldi; Gelbwurz; Indian saffron; Curcumin I; Souchet; Halud; Halad; Haidr; Haldar; Merita earth; Yellow Ginger; Terra Merita; Yellow Root; Safran d'Inde; Yo-Kin; Golden seal; Curcuma oil; Orange Root; Oils, curcuma; CI Natural Yellow 3; Curcumine; Hydrastis; Indian turmeric; Yellow puccoon; Turmeric extract; Diferaloylmethane; Kurkumin [Czech]; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione; Tumeric yellow; Turmeric oil
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  Disease Class 2A00-2F9Z: Solid tumour/cancer
  Therapeutic Class Herbal Products
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C21H20O6
  InChI 1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
  InChIKey VFLDPWHFBUODDF-FCXRPNKRSA-N
  Canonical SMILES COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
  External Link
Pubchem ID 969516
CAS Number 458-37-7
CHEBI ID 3962
TTD ID D07SDQ
INTEDE ID DR1941
VARIDT ID DR00559

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM050  Increased risk of bleeding
BM064  Increased risk of hypoglycemia
  Relation Graph
 Full list of drugs interacting with Turmeric
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  39
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0005
 
Abciximab
 
NA
 
NA
Minor    Inter Info   
[4], [5], [6]
D0017
 
Acetylsalicylic acid
 
C9H8O4
 
2244 
Minor    Inter Info   
[4], [7], [6]
D0047
 
Alteplase
 
NA
 
NA
Minor    Inter Info   
[4], [5], [6]
D0087
 
Anisindione
 
C16H12O3
 
2197 
Minor    Inter Info   
[4], [5], [6]
D0088
 
Anistreplase
 
NA
 
NA
Minor    Inter Info   
[4], [5], [6]
D0092
 
Antithrombin Alfa
 
NA
 
NA
Minor    Inter Info   
[4], [7], [6]
D0093
 
Antithrombin III human
 
NA
 
NA
Minor    Inter Info   
[4], [7], [6]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Minor    Inter Info   
[4], [5], [6]
D0102
 
Ardeparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[4], [5], [6]
D0104
 
Argatroban
 
C23H36N6O5S
 
92722 
Minor    Inter Info   
[4], [5], [6]
D0176
 
Betrixaban
 
C23H22ClN5O3
 
10275777 
Minor    Inter Info   
[4], [5], [6]
D0189
 
Bivalirudin
 
C98H138N24O33
 
16129704 
Minor    Inter Info   
[4], [5], [6]
D0247
 
Cangrelor
 
C17H25Cl2F3N5O12P3S2
 
9854012 
Minor    Inter Info   
[4], [5], [6]
D0250
 
Caplacizumab
 
NA
 
NA
Minor    Inter Info   
[4], [5], [6]
D0364
 
Clopidogrel
 
C16H16ClNO2S
 
60606 
Minor    Inter Info   
[4], [5], [6]
D0414
 
Dalteparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[4], [5], [6]
D0415
 
Danaparoid
 
NA
 
NA
Minor    Inter Info   
[4], [5], [6]
D0435
 
Defibrotide
 
C20H21N4O6P
 
135565962 
Minor    Inter Info   
[4], [5], [6]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Minor    Inter Info   
[4], [7], [6]
D0506
 
Dipyridamole
 
C24H40N8O4
 
3108 
Minor    Inter Info   
[4], [5], [6]
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Minor    Inter Info   
[4], [5], [6]
D0574
 
Enoxaparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[4], [5], [6]
D0588
 
Eptifibatide
 
C35H49N11O9S2
 
448812 
Minor    Inter Info   
[4], [5], [6]
D0690
 
Fondaparinux
 
C31H53N3O49S8
 
5282448 
Minor    Inter Info   
[4], [5], [6]
D0753
 
Heparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[4], [5], [6]
D0904
 
Lepirudin
 
C287H440N80O111S6
 
118856773 
Minor    Inter Info   
[4], [5], [6]
D1328
 
Prasugrel
 
C20H20FNO3S
 
6918456 
Minor    Inter Info   
[4], [5], [6]
D1395
 
Reteplase
 
NA
 
NA
Minor    Inter Info   
[4], [5], [6]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Minor    Inter Info   
[4], [5], [6]
D1506
 
Streptokinase
 
C11H19NO2
 
9815560 
Minor    Inter Info   
[4], [5], [6]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Minor    Inter Info   
[4], [5], [6]
D1550
 
Tenecteplase
 
NA
 
NA
Minor    Inter Info   
[4], [5], [6]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Minor    Inter Info   
[4], [5], [6]
D1581
 
Ticlopidine
 
C14H14ClNS
 
5472 
Minor    Inter Info   
[4], [5], [6]
D1588
 
Tinzaparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[4], [5], [6]
D1593
 
Tirofiban
 
C22H36N2O5S
 
60947 
Minor    Inter Info   
[4], [5], [6]
D1669
 
Urokinase
 
NA
 
NA
Minor    Inter Info   
[4], [5], [6]
D1705
 
Vorapaxar
 
C29H33FN2O4
 
10077130 
Minor    Inter Info   
[4], [5], [6]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Minor    Inter Info   
[4], [5], [6]
   Increased risk of hypoglycemia Drug Num:  36
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0009
 
Acarbose
 
C25H43NO18
 
41774 
Moderate    Inter Info   
[1], [2], [3]
D0013
 
Acetohexamide
 
C15H20N2O4S
 
1989 
Moderate    Inter Info   
[1], [2], [3]
D0029
 
Albiglutide
 
C148H224N40O45
 
145994868 
Moderate    Inter Info   
[1], [2], [3]
D0042
 
Alogliptin
 
C18H21N5O2
 
11450633 
Moderate    Inter Info   
[1], [2], [3]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[1], [2], [3]
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Moderate    Inter Info   
[1], [2], [3]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[1], [2], [3]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[1], [2], [3]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Moderate    Inter Info   
[1], [2], [3]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Moderate    Inter Info   
[1], [2], [3]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Moderate    Inter Info   
[1], [2], [3]
D0807
 
Insulin aspart (aspart protamine)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[1], [2], [3]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[1], [2], [3]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Moderate    Inter Info   
[1], [2], [3]
D0810
 
Insulin detemir
 
C267H402N64O76S6
 
16137271 
Moderate    Inter Info   
[1], [2], [3]
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Moderate    Inter Info   
[1], [2], [3]
D0813
 
Insulin human
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0816
 
Insulin human (regular)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[1], [2], [3]
D0819
 
Insulin lispro
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[1], [2], [3]
D0820
 
Insulin lispro (protamine)
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[1], [2], [3]
D0930
 
Linagliptin
 
C25H28N8O2
 
10096344 
Moderate    Inter Info   
[1], [2], [3]
D0936
 
Liraglutide
 
C172H265N43O51
 
16134956 
Moderate    Inter Info   
[1], [2], [3]
D1015
 
Metformin
 
C4H11N5
 
4091 
Moderate    Inter Info   
[1], [2], [3]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Moderate    Inter Info   
[1], [2], [3]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Moderate    Inter Info   
[1], [2], [3]
D1326
 
Pramlintide
 
C171H267N51O53S2
 
70691388 
Moderate    Inter Info   
[1], [2], [3]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[1], [2], [3]
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Moderate    Inter Info   
[1], [2], [3]
D1449
 
Saxagliptin
 
C18H25N3O2
 
11243969 
Moderate    Inter Info   
[1], [2], [3]
D1477
 
Sitagliptin
 
C16H15F6N5O
 
4369359 
Moderate    Inter Info   
[1], [2], [3]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Moderate    Inter Info   
[1], [2], [3]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Moderate    Inter Info   
[1], [2], [3]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[1], [2], [3]
References
1 Neerati R, Devde R, Gangi AK "Evaluation of the effects of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus." Phytother Res 28 (2014): 1796-1800
2 Chuengsamarn S, Rattanamongkolgul s, Luechapudiporn R, Phisalaphong C, Jirawatnotai S "Curcumin extract for prevention of type 2 diabetes." Diabetes Care 35 (2012): 2121-7
3 Hodaei H, Adibian M, Nikpayam O, Hedayati M, Sohrab G "The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial." Diabet Metab Syndr 11 (2019): e-collection 2019
4 Abebe W "Herbal medication: potential for adverse interactions with analgesic drugs." J Clin Pharm Ther 27 (2002): 391-401. [PMID: 12472978]
5 Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
6 Yang X, Thomas DP, Zhang X, et al "Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation." Arterioscler Thromb Vasc Biol 26 (2006): 85-90. [PMID: 16239599]
7 Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]