Drug General Information (ID: DDI7NLP4ZB)
  Drug Name Betrixaban Drug Info Turmeric Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Anticoagulants/Factor Xa Inhibitors Herbal Products
  Structure

 Mechanism of Betrixaban-Turmeric Interaction (Severity Level: Minor)
     Increased risk of bleeding Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Betrixaban Turmeric
      Mechanism Risk of bleeding
Anticoagulant 
Risk of bleeding
Antiplatelet effects 
      Key Mechanism Factor 1
Factor Name Bleeding
Factor Description Patients may be at risk for bleeding when the outcome of a disease or disease treatment confounds the standard mechanisms for maintaining hemostasis. Signs or symptoms of abnormal bleeding include: bleeding that takes a long time to stop (including nosebleeds, bleeding gums, bleeding from cuts and abrasions, and menstrual bleeding); severe unexplained bruising, or bruising that becomes larger; blood in the urine or stool, etc.
      Mechanism Description
  • Increased risk of bleeding by the combination of Betrixaban and Turmeric 

References
1 Abebe W "Herbal medication: potential for adverse interactions with analgesic drugs." J Clin Pharm Ther 27 (2002): 391-401. [PMID: 12472978]
2 Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
3 Yang X, Thomas DP, Zhang X, et al "Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation." Arterioscler Thromb Vasc Biol 26 (2006): 85-90. [PMID: 16239599]