Details of Drug

Drug General Information (ID: D1630)
Drug Name	Triamcinolone (ophthalmic)
Drug Type	Small molecule
Drug Synonymous	Adcortyl; Aristocort; Celeste; Cinolone; Delphicort; Fluoxiprednisolone; Fluoxyprednisolone; Fougera; Ione; Kenacort; Ledercort; Mycolog; Omcilon; Omicilon; Orion; Rodinolone; Tiamcinolonum; Triamcet; Triamcinalone; Triamcinlon; Triamcinolon; Triamcinolona; Triamcinolonum; Tricortale; Trilone; Tristoject; Volon; Aristocort Tablets; Triamcinolonum [INN]; CL 19823; Aristocort (TN); Azmacort (TN); Cinolone-T; Fougera (TN); Kenacort (TN); Kenacort-AG; Kenalog (TN); Nasacort (TN); SK-Triamcinolone; Tiamcinolonum [INN-Latin]; Triam-Tablinen; Triamcinolona [INN-Spanish]; Tricortone (TN); Triderm (TN); Triesence (TN); Trilone (TN); Tristoject (TN); Volon A (TN); Tri-Nasal (TN); Triamcinolone (JP15/USP/INN); Triamcinolone [USAN:INN:BAN:JAN]; Droxypregna-1,4-diene-3,20-dione; Pregna-1,4-diene-3,20-dio; TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7)); Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy-(8CI); Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha); (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; 11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione; 11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione; 11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione; 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9-alpha-Fluoro-16-alpha-hydroxyprednisolone; 9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy; 9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; 9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d; 9.Alpha.-Fluoro-16.alpha.-hydroxyprednisolone; 9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; 9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone; 9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; 9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha-hydroxyprednisolone Click to Show/Hide
Disease Class	CA08: Vasomotor/allergic rhinitis
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C21H27FO6
InChI	1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
InChIKey	GFNANZIMVAIWHM-OBYCQNJPSA-N
Canonical SMILES	CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CCC4=CC(=O)C=CC43C)F)O
External Link
	Pubchem ID	31307
	CAS Number	124-94-7
	CHEBI ID	9667
	TTD ID	D03BLF

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM015 Increase globulin concentration BM017 CYP450 enzyme inhibition BM024 Competitive inhibition of metabolic enzyme BM031 Increased renal excretion (Unspecific) BM043 Additive immunosuppressive effects BM054 Increased risk of GI mucosal injury/bleeding risk BM065 Increased risk of hypokalemia BM083 Potentiated the pharmacological effects (Unspecific) BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM091 Antagonize the effect of cholinergic agents BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Triamcinolone (ophthalmic)
Affected organization distribution
	Increase globulin concentration					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[35], [36], [37]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[35], [36], [37]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[35], [36], [37]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[35], [36], [37]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[35], [36], [37]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[35], [36], [37]
D0608		Estramustine	C23H31Cl2NO3	259331	Moderate		Inter Info	[35], [36], [37]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[35], [36], [37]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[35], [36], [37]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[35], [36], [37]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[35], [36], [37]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[35], [36], [37]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[35], [36], [37]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[42], [43], [44]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[42], [43], [44]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[42], [43], [44]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[42], [43], [44]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[42], [43], [44]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[42], [43], [44]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[42], [43], [44]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[42], [43], [44]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[42], [43], [44]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[42], [43], [44]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[42], [43], [44]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[42], [43], [44]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[42], [43], [44]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[42], [43], [44]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[42], [43], [44]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[42], [43], [44]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[42], [43], [44]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[42], [43], [44]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[42], [43], [44]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[42], [43], [44]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[42], [43], [44]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[42], [43], [44]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[42], [43], [44]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[42], [43], [44]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[42], [43], [44]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[42], [43], [44]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[42], [43], [44]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[42], [43], [44]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[38], [39], [40]
Affected excretion pathways
	Increased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[73], [74], [75]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[4], [5]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3]
D1111		Natalizumab	NA	NA	Major		Inter Info	[6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[7], [4], [8]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [2], [3]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[9]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[10], [11]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[4], [12]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[7], [13]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[10], [11]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[18]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[19]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[14], [26], [27]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[28], [27]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[29], [30], [31]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[41]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[29], [30], [31]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[27], [66]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[67]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[67]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[67]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[70]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[71]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[4], [72]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[32], [33], [34]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[32], [33], [34]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[32], [33], [34]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[32], [33], [34]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[32], [33], [34]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[32], [33], [34]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[32], [33], [34]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[32], [33], [34]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[32], [33], [34]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[32], [33], [34]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[52], [53], [54]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[32], [33], [34]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[52], [53], [54]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[32], [33], [34]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[32], [33], [34]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[32], [33], [34]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[32], [33], [34]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[32], [33], [34]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[32], [33], [34]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[32], [33], [34]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[32], [33], [34]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[32], [33], [34]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[32], [33], [34]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[52], [53], [54]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[32], [33], [34]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[52], [53], [54]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[52], [53], [54]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[32], [33], [34]
	Increased risk of hypokalemia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[45], [46], [47]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[45], [46], [47]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[45], [46], [47]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[45], [46], [47]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[45], [46], [47]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[45], [46], [47]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[45], [46], [47]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[45], [46], [47]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[45], [46], [47]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[45], [46], [47]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[45], [46], [47]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[45], [46], [47]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[45], [46], [47]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0677		Fluoxymesterone	C20H29FO3	6446	Moderate		Inter Info	[68], [69]
D1042		Methyltestosterone	C20H30O2	6010	Moderate		Inter Info	[68], [69]
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[68], [69]
D1207		Oxymetholone	C21H32O3	5281034	Moderate		Inter Info	[68], [69]
D1503		Stanozolol	C21H32N2O	25249	Moderate		Inter Info	[68], [69]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[68], [69]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1694		Vigabatrin	C6H11NO2	5665	Major		Inter Info	[20], [21], [22]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[23], [24], [25]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[23], [24], [25]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[23], [24], [25]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[23], [24], [25]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [24], [25]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [24], [25]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [24], [25]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [24], [25]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [24], [25]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [24], [25]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[23], [24], [25]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[23], [24], [25]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[23], [24], [25]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[23], [24], [25]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[23], [24], [25]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[23], [24], [25]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[23], [24], [25]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[23], [24], [25]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[23], [24], [25]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[23], [24], [25]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[23], [24], [25]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[23], [24], [25]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[23], [24], [25]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[23], [24], [25]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[23], [24], [25]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[23], [24], [25]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[23], [24], [25]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[23], [24], [25]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[23], [24], [25]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[23], [24], [25]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[23], [24], [25]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[23], [24], [25]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[23], [24], [25]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[23], [24], [25]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[23], [24], [25]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[23], [24], [25]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[23], [24], [25]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[23], [24], [25]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[23], [24], [25]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[23], [24], [25]
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[23], [24], [25]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[23], [24], [25]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[23], [24], [25]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[23], [24], [25]
	Antagonize the effect of cholinergic agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1365		Pyridostigmine	C9H13N2O2+	4991	Moderate		Inter Info	[49], [50], [51]
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Moderate		Inter Info	[49], [50], [51]
D0552		Edrophonium	C10H16NO+	3202	Moderate		Inter Info	[49], [50], [51]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[49], [50], [51]
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[14], [15], [16]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[17]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[48]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[14], [55], [56]
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Moderate		Inter Info	[57], [58], [59]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[14], [55], [56]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[14], [55], [56]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[14], [55], [56]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[14], [55], [56]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[14], [55], [56]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[14], [55], [56]
D1839		Measles virus vaccine live attenuated	NA	NA	Moderate		Inter Info	[57], [58], [59]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[14], [55], [56]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Moderate		Inter Info	[57], [58], [59]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[14], [55], [56]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[14], [55], [56]
D1881		Rotavirus vaccine	NA	NA	Moderate		Inter Info	[57], [58], [59]
D1882		Rubella virus vaccine	NA	NA	Moderate		Inter Info	[57], [58], [59]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[14], [55], [56]
D1914		Typhoid vaccine (live)	NA	NA	Moderate		Inter Info	[57], [58], [59]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[57], [58], [59]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[14], [55], [56]
D1922		Yellow Fever Vaccine	NA	NA	Moderate		Inter Info	[57], [58], [59]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[60], [61], [62]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[60], [61], [62]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[63], [64], [65]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[63], [64], [65]

References
1	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
2	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
3	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFa) blockers now include warnings about infection with Legionella and Listeria bacteria. ".
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
6	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
7	Cerner Multum, Inc. "Australian Product Information.".
8	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
9	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
10	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
11	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
12	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
13	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
14	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
15	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
16	CDC. Centers for Disease Control and Prevention "Clinical guidance for smallpox vaccine use in a postevent vaccination program.".
17	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
18	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
19	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
20	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
21	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
22	Product Information. Sabril (vigabatrin). Lundbeck Inc, Deerfield, IL.
23	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
24	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
25	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
26	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
27	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
28	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
29	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
30	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
31	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
32	Messer J, Reitman D, Sacks HS, et al "Association of adrenocorticosteroid therapy and peptic-ulcer disease." N Engl J Med 309 (1983): 21-4. [PMID: 6343871]
33	Stewart JT, Pennington CR, Pringle R "Anti-inflammatory drugs and bowel perforations and haemorrhage." Br Med J 290 (1985): 787-8. [PMID: 3918755]
34	Wilcox CM, Shalek KA, Cotsonis G "Striking prevalence of over-the-counter nonsteroidal anti- inflammatory drug use in patients with upper gastrointestinal hemorrhage." Arch Intern Med 154 (1994): 42-6. [PMID: 8267488]
35	Legler UF, Benet LZ "Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives." Clin Pharmacol Ther 39 (1986): 425-9
36	Meffin PJ, Wing LM, Sallustio BC, Brooks PM "Alterations in prednisolone as a result of oral contraceptive use and dose." Br J Clin Pharmacol 17 (1984): 655-64
37	Frey BM, Schaad HJ, Frey FJ "Pharmacokinetic interaction of contraceptive steroids with prednisone and prednisolone." Eur J Clin Pharmacol 26 (1984): 505-11
38	Durrant S, Chipping PM, Palmer S, Gordon-Smith EC "Cyclosporin A, methylprednisolone, and convulsions." Lancet 2 (1982): 829-30. [PMID: 6126705]
39	Klintmalm G, Sawe J "High dose methylprednisolone increases plasma cyclosporin levels in renal transplant recipients." Lancet 1 (1984): 731. [PMID: 6143058]
40	Ost L "Effects of cyclosporin on prednisolone metabolism." Lancet 1 (1984): 451. [PMID: 6142174]
41	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
42	Edsbacker S, Andersson T "Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease." Clin Pharmacokinet 43 (2004): 803-21. [PMID: 15355126]
43	Finkenbine RD, Frye MD "Case of psychosis due to prednisone-clarithromycin interaction." Gen Hosp Psychiat 20 (1998): 325-6. [PMID: 9788033]
44	Soldatos G, Sztal-Mazer S, Woolley I, Stockigt J "Exogenous glucocorticoid excess as a result of ritonavir-fluticasone interaction." Intern Med J 35 (2005): 67-8. [PMID: 15667475]
45	Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
46	Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
47	Leach MJ, Page AT. Herbal medicine for insomnia: A systematic review and meta-analysis. Sleep Med Rev. 2015 Dec;24:1-12.
48	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
49	Brunner NG, Namba T, Grob D "Corticosteroids in management of severe, generalized myasthenia gravis." Neurology 22 (1972): 603-10
50	Namba T "Corticotropin therapy in patients with myasthenia gravis." Arch Neurol 26 (1972): 144-50
51	Patten BM, Oliver KL, Engel WK "Adverse interaction between steroid hormones and anticholinesterase drugs." Neurology 24 (1974): 442-9
52	Hansen RA, Tu W, Wang J, Ambuehl R, McDonald CJ, Murray MD "Risk of adverse gastrointestinal events from inhaled corticosteroids." Pharmacotherapy 28 (2008): 1325-34. [PMID: 18956992]
53	Koren G, Roifman C, Gelfand E, Lavi S, Suria D, Stein L "Corticosteroids-salicylate interaction in a case of juvenile rheumatoid arthritis." Ther Drug Monit 9 (1987): 177-9. [PMID: 3617157]
54	Piper JM, Ray WA, Daugherty JR, Griffin MR "Corticosteroid use and peptic ulcer disease: role of nonsteroidal ani-inflammatory drugs." Ann Intern Med 114 (1991): 735-40. [PMID: 2012355]
55	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
56	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
57	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
58	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
59	Product Information. Orimune (poliovirus vaccine, live, oral, trivalent). Lederle Laboratories, Philadelphia, PA.
60	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
61	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
62	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
63	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
64	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
65	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
66	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
67	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
68	Product Information. AndroGel (testosterone). Unimed Pharmaceuticals, Buffalo Grove, IL.
69	Product Information. Oxandrin (oxandrolone). Bio-Tech, Levittown, PA.
70	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
71	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
72	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
73	Dimartini A "Isoniazid, tricyclics and the ''cheese reaction''." Int Clin Psychopharmacol 10 (1995): 197-8. [PMID: 8675973]
74	Sarma G, Kailasam S, Nair NG, Narayana AS, Tripathy SP "Effect of prednisonlone and refampin on isoniazid metabolism in slow and rapid inactivators of isoniazid." Antimicrob Agents Chemother 18 (1980): 661-6
75	Brodie MJ, Boobis AR, Hillyard CJ, Abeyasekera G, MacIntyre I, Park BK "Effect of isoniazid on vitamin D metabolism and hepatic monooxygenase activity." Clin Pharmacol Ther 30 (1981): 363-7

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence