Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDINHBUWG5)
  Drug Name Nabumetone Drug Info Triamcinolone (ophthalmic) Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Nsaids/Analgesics Antiinflammatory Agents
  Structure

 Mechanism of Nabumetone-Triamcinolone (ophthalmic) Interaction (Severity Level: Moderate)
     Increased risk of GI mucosal injury/bleeding risk Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Nabumetone Triamcinolone (ophthalmic)
      Mechanism GI mucosal injury/bleeding risk GI mucosal injury/bleeding risk
      Key Mechanism Factor 1
Factor Name Gastrointestinal toxicity
Factor Description The risk and severity of gastrointestinal toxicity, including inflammation, bleeding, ulceration, and perforation, increases when drugs with gastrointestinal mucosal irritant effects are combined.
      Mechanism Description
  • Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Triamcinolone (ophthalmic) 

Recommended Action
      Management Caution is advised if corticosteroids and NSAIDs are used together, especially in patients with a prior history of peptic ulcer disease or GI bleeding and in elderly and debilitated patients. During concomitant therapy, patients should be advised to take the medications with food and to immediately report signs and symptoms of GI ulceration and bleeding such as severe abdominal pain, dizziness, lightheadedness, and the appearance of black, tarry stools. The selective use of prophylactic anti-ulcer therapy (e.g., antacids, H2-antagonists) may be considered.

References
1 Messer J, Reitman D, Sacks HS, et al "Association of adrenocorticosteroid therapy and peptic-ulcer disease." N Engl J Med 309 (1983): 21-4. [PMID: 6343871]
2 Stewart JT, Pennington CR, Pringle R "Anti-inflammatory drugs and bowel perforations and haemorrhage." Br Med J 290 (1985): 787-8. [PMID: 3918755]
3 Wilcox CM, Shalek KA, Cotsonis G "Striking prevalence of over-the-counter nonsteroidal anti- inflammatory drug use in patients with upper gastrointestinal hemorrhage." Arch Intern Med 154 (1994): 42-6. [PMID: 8267488]