Details of Drug

Drug General Information (ID: D1623)
Drug Name	Trastuzumab emtansine
Drug Type	Monoclonal antibody
Disease Class	2C60-2C6Y: Breast cancer
Therapeutic Class	Antineoplastics/Her2 Inhibitors
External Link
External Link	TTD ID	D0UG0K

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy
Relation Graph

Full list of drugs interacting with Trastuzumab emtansine
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[1], [3], [28]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[1], [3], [28]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1], [3], [28]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[41], [42]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[1], [3], [28]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[1], [3], [28]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[1], [3], [28]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[1], [3], [28]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[1], [3], [28]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[1], [3], [28]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[1], [3], [28]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1], [3], [28]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[1], [3], [28]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[1], [3], [28]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[1], [3], [28]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1], [3], [28]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[62]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[1], [3], [28]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1], [3], [28]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1], [2], [70]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[1], [3], [28]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[1], [3], [28]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[1], [3], [28]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1], [3], [28]
	CYP450 enzyme induction					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1], [2], [57]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[68]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1], [2], [57]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1], [2], [57]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 88
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[1], [2], [3]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1], [2], [3]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1], [2], [3]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1], [2], [3]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2], [3]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1], [2], [3]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [4]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[5], [6]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[1], [2], [3]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1], [2], [3]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[7]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2], [3]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[1], [2], [3]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0754		Heparin (flush)	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1], [2], [3]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1], [2], [3]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[8], [12], [5]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[5], [13]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1], [2], [3]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[2], [14]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1], [2], [3]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[15], [16]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[1], [2], [3]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D0415		Danaparoid	NA	NA	Major		Inter Info	[1], [2], [3]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[1], [2], [3]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1], [2], [3]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[17], [18], [2]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[2], [5], [19]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2], [21]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[5], [23]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1], [2], [3]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[2], [24], [25]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1], [2], [3]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1], [2], [3]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[5]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1], [2], [3]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[34], [35], [36]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[37], [38], [39]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[37], [38], [39]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[5], [43]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[37], [38], [39]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[34], [35], [36]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[34], [35], [36]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[34], [35], [36]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[34], [35], [36]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[37], [38], [39]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[46], [47], [48]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[37], [38], [39]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[34], [35], [36]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[37], [38], [39]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[34], [35], [36]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[34], [35], [36]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[37], [38], [39]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[49]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[34], [35], [36]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[46], [47], [48]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[34], [35], [36]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[34], [35], [36]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[34], [35], [36]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[34], [35], [36]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[34], [35], [36]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[34], [35], [36]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[34], [35], [36]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[37], [38], [39]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[34], [35], [36]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[34], [35], [36]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[37], [38], [39]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[5], [56]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[34], [35], [36]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[34], [35], [36]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[37], [38], [39]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[37], [38], [39]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[34], [35], [36]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[37], [38], [39]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[34], [35], [36]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[2], [71]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[37], [38], [39]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[37], [38], [39]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[46], [47], [48]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[37], [38], [39]
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[8], [9], [10]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[11]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[20]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[22]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[8], [9], [10]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[29], [1], [30]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[40]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[44], [45]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[50], [51], [52]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[50], [51], [52]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[2], [53], [54]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[55]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[29], [1], [30]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[59], [60]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [61]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[29], [1], [30]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[63], [64]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[65], [66]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[29], [1], [30]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[2], [67]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[69]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[50], [51], [52]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[72], [73], [74]
	Increased risk of peripheral neuropathy					Drug Num: 76
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[26], [24], [27]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[26], [24], [27]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[26], [24], [27]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[31], [32], [33]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[26], [24], [27]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[26], [24], [27]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[26], [24], [27]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[26], [24], [27]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[26], [24], [27]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[26], [24], [27]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[26], [24], [27]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[26], [24], [27]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[26], [24], [27]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[26], [24], [27]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[26], [24], [27]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[26], [24], [27]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[26], [24], [27]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[26], [24], [27]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[26], [24], [27]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[26], [24], [27]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[26], [24], [27]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[26], [24], [27]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[26], [24], [27]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[26], [24], [27]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[26], [24], [27]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[26], [24], [27]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[26], [24], [27]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[26], [24], [27]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[26], [24], [27]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[26], [24], [27]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[26], [24], [27]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[26], [24], [27]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[26], [24], [27]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[26], [24], [27]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[26], [24], [27]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[26], [24], [27]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[26], [24], [27]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[26], [24], [27]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[26], [24], [27]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[26], [24], [27]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[26], [24], [27]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[31], [1], [58]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[26], [24], [27]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[26], [24], [27]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[26], [24], [27]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[26], [24], [27]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[26], [24], [27]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[26], [24], [27]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[26], [24], [27]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[26], [24], [27]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[26], [24], [27]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[26], [24], [27]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[26], [24], [27]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[26], [24], [27]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[26], [24], [27]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[26], [24], [27]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[26], [24], [27]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[26], [24], [27]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[26], [24], [27]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[26], [24], [27]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[26], [24], [27]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[26], [24], [27]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[26], [24], [27]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[26], [24], [27]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[26], [24], [27]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[31], [63]

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