Details of Drug

Drug General Information (ID: D1609)
Drug Name	Topiramate
Drug Type	Small molecule
Drug Synonymous	Epitoma; Epitomax; TOR; Tipiramate; Tipiramato; Topamac; Topamax; Topimax; Topina; Topiramato; Topiramatum; Topomax; Cilag brandof topiramate; Janssen brand of topiramate; Ortho brand of topiramate; Tipiramate [French]; Tipiramato [Spanish]; Topamax Sprinkle; Topiramate tablet; Topiramatum [Latin]; Topiramic acid; McN 4853; RWJ 17021; KS-1122; KW-6485; McN-4853; RWJ-17021; Topamax (TN); Topamax, Topiramate; Topiramate (TPM); Topiramate / Placebo; Topiramato [INN-Spanish]; Topiramatum [INN-Latin]; USL-255; RWJ-17021-000; Topiramate [USAN:BAN:INN]; Topiramate (JAN/USAN/INN); Beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate; Beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI);Beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate; [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate; 2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate; 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate; 2,3:4,5-Di-O-isopropylidene-(beta)-D-fructopyranose sulfamate; 2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate; 5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, beta Click to Show/Hide
Disease Class	6C40: Substance abuse; 8A61-8A6Z: Epilepsy/seizure
Therapeutic Class	Anticonvulsants
Structure
Structure	3D Structure		2D Structure
Formula	C12H21NO8S
InChI	1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
InChIKey	KJADKKWYZYXHBB-XBWDGYHZSA-N
Canonical SMILES	CC1(OC2COC3(C(C2O1)OC(O3)(C)C)COS(=O)(=O)N)C
External Link
	Pubchem ID	5284627
	CAS Number	97240-79-4
	CHEBI ID	63631
	TTD ID	D07VDZ
	INTEDE ID	DR1618
	VARIDT ID	DR01372

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM025 Decreased metabolism (Unspecific) BM038 Additive CNS depression effects BM056 Increased risk of hyperammonemia BM061 Increased risk of hyperpyrexia BM070 Increased risk of metabolic acidosis BM085 Antagonize the effect of antithrombotic agents BM087 Antagonize the effect of antiepileptic agents BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Topiramate
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[40], [54]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[60], [52], [40], [61], [2], [62]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[2], [69], [70]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[2], [69], [70]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[40], [85]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[40], [89]
	Decreased metabolism (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[60], [2]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[60], [2]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[60], [2]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 194
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0160		Benzatropine	C21H25NO	1201549	Major		Inter Info	[1], [2], [3]
D0020		Acrivastine	C22H24N2O2	5284514	Major		Inter Info	[2]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[1], [2], [3]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[2]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[2]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Major		Inter Info	[2]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[2]
D0123		Atropine	C17H23NO3	174174	Major		Inter Info	[2]
D0135		Azatadine	C20H22N2	19861	Major		Inter Info	[2]
D0154		Belladonna	C34H42N2O4	265028	Major		Inter Info	[2]
D0183		Biperiden	C21H29NO	2381	Major		Inter Info	[2]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[2]
D0214		Brompheniramine	C16H19BrN2	6834	Major		Inter Info	[2]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21]
D0259		Carbinoxamine	C16H19ClN2O	2564	Major		Inter Info	[2]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[2]
D0316		Chlorcyclizine	C18H21ClN2	2710	Major		Inter Info	[2]
D0323		Chlorpheniramine	C16H19ClN2	2725	Major		Inter Info	[2]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[2]
D0351		Clemastine	C21H26ClNO	26987	Major		Inter Info	[2]
D0353		Clidinium	C22H26NO3+	2784	Major		Inter Info	[2]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[2]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[2]
D0397		Cyclizine	C18H22N2	6726	Major		Inter Info	[2]
D0398		Cyclobenzaprine	C20H21N	2895	Major		Inter Info	[2]
D0403		Cyproheptadine	C21H21N	2913	Major		Inter Info	[2]
D0424		Darifenacin	C28H30N2O2	444031	Major		Inter Info	[2]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[2]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Major		Inter Info	[2]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[22], [23], [24]
D0482		Dicyclomine	C19H35NO2	3042	Major		Inter Info	[2]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Major		Inter Info	[2]
D0502		Diphenhydramine	C17H21NO	3100	Major		Inter Info	[2]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[2]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[1], [2], [3]
D0532		Doxylamine	C17H22N2O	3162	Major		Inter Info	[2]
D0662		Flavoxate	C24H25NO4	3354	Major		Inter Info	[2]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[2]
D0733		Glycopyrronium	C19H28NO3+	3494	Major		Inter Info	[1], [2], [3]
D0759		Homatropine	C16H21NO3	5282593	Major		Inter Info	[1], [2], [3]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[2]
D0782		Hyoscyamine	C17H23NO3	154417	Major		Inter Info	[2]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[2]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[2]
D0957		Loxapine	C18H18ClN3O	3964	Major		Inter Info	[2]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[2]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[2]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[2]
D0987		Meclizine	C25H27ClN2	4034	Major		Inter Info	[2]
D1000		Mepenzolate	C21H26NO3+	4057	Major		Inter Info	[2]
D1006		Mepyramine	C17H23N3O	4992	Major		Inter Info	[1], [2], [3]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[2]
D1019		Methdilazine	C18H20N2S	14677	Major		Inter Info	[2]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[2]
D1031		Methscopolamine	C18H24NO4+	71183	Major		Inter Info	[2]
D1084		Molindone	C16H24N2O2	23897	Major		Inter Info	[2]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[2]
D1188		Orphenadrine	C18H23NO	4601	Major		Inter Info	[2]
D1202		Oxybutynin	C22H31NO3	4634	Major		Inter Info	[2]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[2]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[2]
D1264		Phenindamine	C19H19N	11291	Major		Inter Info	[2]
D1282		Phenyltoloxamine	C17H21NO	7077	Major		Inter Info	[1], [2], [3]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[2]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[2]
D1347		Procyclidine	C19H29NO	4919	Major		Inter Info	[2]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[2]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[2]
D1354		Propantheline	C23H30NO3+	4934	Major		Inter Info	[2]
D1355		Propiomazine	C20H24N2OS	4940	Major		Inter Info	[2]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[2]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[2]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[2]
D1450		Scopolamine	C17H21NO4	3000322	Major		Inter Info	[2]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[27], [28]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[2]
D1572		Thiethylperazine	C22H29N3S2	5440	Major		Inter Info	[2]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[2]
D1576		Thiothixene	C23H29N3O2S2	941651	Major		Inter Info	[2]
D1607		Tolterodine	C22H31NO	443879	Major		Inter Info	[2]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[2]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[2]
D1641		Trihexyphenidyl	C20H31NO	5572	Major		Inter Info	[2]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[2]
D1649		Tripelennamine	C16H21N3	5587	Major		Inter Info	[2]
D1650		Triprolidine	C19H22N2	5282443	Major		Inter Info	[2]
D1656		Trospium	C25H30NO3+	5284632	Major		Inter Info	[2]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[29], [30], [31]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[29], [30], [31]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[29], [30], [31]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[29], [30], [31]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[29], [30], [31]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[29], [30], [31]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[29], [30], [31]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[29], [30], [31]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[55], [56]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[57], [40], [58]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[29], [30], [31]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[59]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[57], [40], [58]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[57], [40], [58]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[29], [30], [31]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[29], [30], [31]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[29], [30], [31]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[29], [30], [31]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[29], [30], [31]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[29], [30], [31]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[29], [30], [31]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[63], [64]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[29], [30], [31]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[29], [30], [31]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[29], [30], [31]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[29], [30], [31]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[29], [30], [31]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[29], [30], [31]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[29], [30], [31]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[29], [30], [31]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[29], [30], [31]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[29], [30], [31]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[29], [30], [31]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[29], [30], [31]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[29], [30], [31]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[29], [30], [31]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[29], [30], [31]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[29], [30], [31]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[29], [30], [31]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[52], [68]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[29], [30], [31]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[29], [30], [31]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[29], [30], [31]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[2]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[29], [30], [31]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[71]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[29], [30], [31]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[29], [30], [31]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[29], [30], [31]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[29], [30], [31]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[29], [30], [31]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[29], [30], [31]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[29], [30], [31]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[77]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[29], [30], [31]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[29], [30], [31]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[63], [64]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[29], [30], [31]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[78], [79], [80], [81], [82]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[29], [30], [31]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[29], [30], [31]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[29], [30], [31]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[29], [30], [31]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[29], [30], [31]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[29], [30], [31]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[29], [30], [31]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[29], [30], [31]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[29], [30], [31]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[29], [30], [31]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[29], [30], [31]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[29], [30], [31]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[83], [84], [85]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[29], [30], [31]
D1183		Opium	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[29], [30], [31]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[29], [30], [31]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[29], [30], [31]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[29], [30], [31]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[29], [30], [31]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[29], [30], [31]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[29], [30], [31]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[29], [30], [31]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[29], [30], [31]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[29], [30], [31]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[29], [30], [31]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[29], [30], [31]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[29], [30], [31]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[29], [30], [31]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[29], [30], [31]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[29], [30], [31]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[29], [30], [31]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[29], [30], [31]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[29], [30], [31]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[29], [30], [31]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[29], [30], [31]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[87]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[88]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[29], [30], [31]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[29], [30], [31]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[29], [30], [31]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[29], [30], [31]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[29], [30], [31]
D1675		Valerian	NA	NA	Moderate		Inter Info	[29], [30], [31]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[29], [30], [31]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[29], [30], [31]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[29], [30], [31]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[29], [30], [31]
	Increased risk of hyperammonemia					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[52], [75], [76]
D1275		Phenylbutyric acid	C10H12O2	4775	Moderate		Inter Info	[52], [75], [76]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[60], [90], [2], [91]
	Increased risk of metabolic acidosis					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0012		Acetazolamide	C4H6N4O3S2	1986	Major		Inter Info	[4], [2], [5]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Major		Inter Info	[4], [2], [5]
D1015		Metformin	C4H11N5	4091	Major		Inter Info	[2], [25], [26]
D1018		Methazolamide	C5H8N4O3S2	4100	Major		Inter Info	[4], [2], [5]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[4], [2], [5]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[52], [40], [53]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[52], [40], [53]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[52], [40], [53]
	Antagonize the effect of antiepileptic agents					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[52], [40], [65], [66], [67]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[52], [40], [65], [66], [67]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1243		Pemoline	C9H8N2O2	4723	Moderate		Inter Info	[52], [40], [86]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[72], [73], [74]

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