Details of Drug

Drug General Information (ID: D1598)
Drug Name	Tocainide
Drug Type	Small molecule
Drug Synonymous	Taquidil; Tocainida; Tocainidum; Tonocard; Astra W 36095; Tocainida [INN-Spanish]; Tocainidum [INN-Latin]; W-36095; Tocainide (USAN/INN); Tocainide [USAN:BAN:INN]; Alanyl-2,6-xylidide; N-(2,6-dimethylphenyl)alaninamide; (-)-2-Amino-N-(2,6-dimethylphenyl)propanamide; 2-AMINO-N-(2,6-DIMETHYLPHENYL)PROPANAMIDE; 2-Amino-2',6'-propionoxylidide; 2-Amino-N-(2,6-dimethylphenyl)propionamid Click to Show/Hide
Disease Class	BC71: Ventricular tachyarrhythmia
Therapeutic Class	Antiarrhythmic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C11H16N2O
InChI	1S/C11H16N2O/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12/h4-6,9H,12H2,1-3H3,(H,13,14)
InChIKey	BUJAGSGYPOAWEI-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=CC=C1)C)NC(=O)C(C)N
External Link
	Pubchem ID	38945
	CAS Number	41708-72-9
	CHEBI ID	9611
	TTD ID	D01PJR
	INTEDE ID	DR1607

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM003 Complex formation BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM076 Increased risk of prolong QT interval
Relation Graph

Full list of drugs interacting with Tocainide
Affected gastrointestinal absorption
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[13], [14]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[22], [23], [24]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[17], [18]
	Additive immunosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [2]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[9]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[25]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[26]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[27]
	Additive myelosuppressive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [3], [4]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[6], [7], [8]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[6], [1], [15], [16]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[6], [1], [15], [16]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[1], [19], [4]
	Increased risk of bradycardia					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[10], [11], [12]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[10], [11], [12]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[10], [11], [12]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[10], [11], [12]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[10], [11], [12]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[10], [11], [12]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[10], [11], [12]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[20], [21]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[10], [11], [12]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[10], [11], [12]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[10], [11], [12]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[10], [11], [12]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[10], [11], [12]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[10], [11], [12]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[10], [11], [12]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[20], [21]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[10], [11], [12]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[10], [11], [12]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[10], [11], [12]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[6], [4]
	Increased risk of prolong QT interval					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[5]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
3	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
4	Canadian Pharmacists Association "e-CPS."
5	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
6	Cerner Multum, Inc. "Australian Product Information.".
7	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
8	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
9	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
10	Rubino M, Jackson E "Severe paranoia with concomitant tocainide and propranolol therapy." Clin Pharm 1 (1982): 177-9
11	Ikram H "Hemodynamic and electrophysiologic interactions between antiarrhythmic drugs and beta blockers, with special reference to tocainide." Am Heart J 100 (1980): 1076-80
12	Roden DM, Woosley RL "Tocainide." N Engl J Med 315 (1986): 41-5
13	Canadian Pharmacists Association.
14	Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
15	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
16	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
17	Product Information. Tonocard (tocainide). Merck & Co, Inc, West Point, PA.
18	Forrence E, Covinsky JO, Mullen C "A seizure induced by concurrent lidocaine-tocainide therapy: is it just a case of additive toxicity?" Drug Intell Clin Pharm 20 (1986): 56-9. [PMID: 3080299]
19	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
20	Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
21	Product Information. Somatuline Depot (lanreotide). Ipsen Inc, Milford, MA.
22	Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6. [PMID: 1558427]
23	Rice TL, Patterson JH, Celestin C, et al "Influence of rifampin on tocainide pharmacokinetics in humans." Clin Pharm 8 (1989): 200-5. [PMID: 2495879]
24	Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8. [PMID: 9385296]
25	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
26	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
27	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.

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