Details of Drug

Drug General Information (ID: D1592)
Drug Name	Tipranavir
Drug Type	Small molecule
Drug Synonymous	Aptivus; TPV; PNU 140690; U 140690; Aptivus (Boehringer Ingelheim); Aptivus (TN); Aptivus(TM); PNU-140690; PNU-140690E; Tipranavir (INN); U-140690; N-[3-[(1R)-1-[(2R)-6-hydroxy-4-oxo-2-phenethyl-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide; N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE Click to Show/Hide
Disease Class	1C60-1C62: Human immunodeficiency virus disease
Therapeutic Class	Anti-Hiv Agents
Structure
Structure	3D Structure		2D Structure
Formula	C31H33F3N2O5S
InChI	1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1
InChIKey	SUJUHGSWHZTSEU-FYBSXPHGSA-N
Canonical SMILES	CCCC1(CC(=C(C(=O)O1)C(CC)C2=CC(=CC=C2)NS(=O)(=O)C3=NC=C(C=C3)C(F)(F)F)O)CCC4=CC=CC=C4
External Link
	Pubchem ID	54682461
	CAS Number	174484-41-4
	CHEBI ID	63628
	TTD ID	D0EV6T
	INTEDE ID	DR1601
	VARIDT ID	DR00962

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM005 Altered gastric pH BM009 Altered absorption (Unspecific) BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions BM079 Increased risk of skin rash BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Tipranavir
Affected gastrointestinal absorption
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[31], [97]
	Altered gastric pH					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[1], [43]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[1], [43]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[1], [43]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[1], [43]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [43]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[1], [43]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[1], [43]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[144]
Affected cellular transport
	Transporter inhibition					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Major		Inter Info	[31], [37], [38]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[31], [44], [45]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[31], [114], [115]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[120]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[31], [125]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[130]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[31], [133]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[31]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[138]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[31]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[147], [44], [148]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[149]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[31], [151]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[46], [31], [153], [154]
	Transporter induction					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[32], [33]
D1139		Nintedanib	C31H33N5O4	135423438	Major		Inter Info	[51]
D1490		Sofosbuvir	C22H29FN3O9P	45375808	Major		Inter Info	[46], [31], [64], [65], [66]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[1]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[1]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[1]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[113]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[1]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[132]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[134]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[46], [31], [137]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [4], [5]
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [4], [5]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [4], [5]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [4], [5]
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[6], [31], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[46], [47], [48]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[46], [31], [49], [48]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [4], [5]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[89]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[1]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[106], [107], [1], [108], [16], [57], [109], [18], [20], [21], [22]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[112]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[46], [31], [121], [39], [122], [20], [123], [63], [124], [101]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[126], [127]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[46], [31], [19]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[128]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[131]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[136]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[139], [140], [141]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[142]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[143]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[150]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[156]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1]
	Non-CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0509		Disulfiram	C10H20N2S4	3117	Major		Inter Info	[26], [27], [28], [1], [29], [30]
	CYP450 enzyme induction					Drug Num: 46
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0515		Dolutegravir	C20H19F2N3O5	54726191	Major		Inter Info	[34], [35], [36]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[1], [39]
D0711		Garlic	NA	NA	Major		Inter Info	[40], [41], [42], [43]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[53], [18], [54]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[55], [56], [24], [46], [31], [15], [1], [16], [17], [57], [18], [20], [58], [21], [22], [59], [60], [43]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[62], [63]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[46], [67], [31], [19]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[24], [31], [1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[21], [59], [43]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[46], [31], [101], [102]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[24], [31], [1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[21], [59], [43]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[118]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[46], [129]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[21], [59], [43]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[31], [145]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[146]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[21], [59], [43]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[31], [152]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[55], [56], [73], [24], [74], [75], [15], [1], [16], [17], [57], [18], [20], [21], [22], [59], [43]
	UGT induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[61]
D1377		Raltegravir	C20H21FN6O5	54671008	Minor		Inter Info	[1], [158]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 63
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1]
D0047		Alteplase	NA	NA	Major		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[24], [1], [25]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[1]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[1]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[24], [1], [25]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1]
D1395		Reteplase	NA	NA	Major		Inter Info	[1]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[1]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[1]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[24], [1], [25]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[24], [1], [25]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[1]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D0415		Danaparoid	NA	NA	Major		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[1]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[1]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[46], [31], [52]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[1]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Major		Inter Info	[1]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[24], [1], [25]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[1]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1]
D1613		Tositumomab	NA	NA	Major		Inter Info	[1]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[24], [1], [25]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1]
D1669		Urokinase	NA	NA	Major		Inter Info	[1]
D1703		Vitamin E	C29H50O2	14985	Major		Inter Info	[1]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[25], [103]
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [19], [5]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[50]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[24], [68], [69]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[77], [78], [79], [46], [31], [80], [81], [82], [83], [84], [85], [86], [87]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[88]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[90], [63]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[46], [31], [91]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[92], [93], [94], [95]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[92], [93], [94], [95]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[31], [96]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[100]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[77], [78], [79], [46], [31], [80], [81], [82], [83], [84], [85], [86], [87]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[110], [111]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[77], [78], [79], [46], [31], [80], [81], [82], [83], [84], [85], [86], [87]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[116]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[117]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[77], [78], [79], [46], [31], [80], [81], [82], [83], [84], [85], [86], [87]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[31], [119]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[135]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[92], [93], [94], [95]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[31], [155]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[2], [3]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[46], [31], [76]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[46], [97], [2], [98], [99]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[104], [31], [105]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[46], [31], [76]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[31], [97], [2], [157]
	Increased risk of skin rash					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[1]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[24], [1]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[24], [1]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[1]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[24], [1]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[1]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[1]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[24], [1]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[24], [1]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[24], [1]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[24], [1]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[1]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[70], [71], [72]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[70], [71], [72]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[70], [71], [72]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[70], [71], [72]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [71], [72]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [71], [72]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [71], [72]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [71], [72]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [71], [72]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [71], [72]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[70], [71], [72]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[70], [71], [72]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[70], [71], [72]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[70], [71], [72]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[70], [71], [72]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[70], [71], [72]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[70], [71], [72]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[70], [71], [72]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[70], [71], [72]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[70], [71], [72]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[70], [71], [72]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[70], [71], [72]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[70], [71], [72]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[70], [71], [72]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[70], [71], [72]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[70], [71], [72]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[70], [71], [72]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[70], [71], [72]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[70], [71], [72]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[70], [71], [72]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[70], [71], [72]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[70], [71], [72]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[70], [71], [72]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[70], [71], [72]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[70], [71], [72]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[70], [71], [72]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[70], [71], [72]
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[70], [71], [72]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[70], [71], [72]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[70], [71], [72]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[70], [71], [72]

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83	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
84	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
85	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
86	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
87	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
88	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
89	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
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91	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
92	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
93	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
94	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
95	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
96	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
97	Multum Information Services, Inc. Expert Review Panel.
98	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
99	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
100	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
101	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
102	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
103	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
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105	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
106	Loulergue P, Gaillard R, Mir O "Interaction involving tadalafil and CYP3A4 inhibition by ritonavir." Scand J Infect Dis 43 (2011): 239-40. [PMID: 20942777]
107	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
108	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
109	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
110	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
111	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
112	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
113	Product Information. Gilotrif (afatinib). Boehringer Ingelheim, Ridgefield, CT.
114	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
115	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
116	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
117	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
118	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
119	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
120	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
121	Product Information. Evotaz (atazanavir-cobicistat). Bristol-Myers Squibb, Princeton, NJ.
122	Product Information. Prezcobix (cobicistat-darunavir). Janssen Pharmaceuticals, Titusville, NJ.
123	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
124	Product Information. Tybost (cobicistat). Gilead Sciences, Foster City, CA.
125	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
126	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
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128	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
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130	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
131	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
132	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
133	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
134	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
135	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
136	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
137	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
138	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
139	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
140	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
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142	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
143	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
144	MHRA. Medicines and Healthcare Products Regulatory Agency "Orlistat: theoretical interaction with antiretroviral HIV medicines.".
145	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
146	Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA.
147	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
148	Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
149	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
150	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
151	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
152	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
153	Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
154	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
155	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
156	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
157	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
158	Product Information. Isentress (raltegravir). Merck & Company Inc, West Point, PA.

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