Details of Drug

Drug General Information (ID: D1566)
Drug Name	Tetraferric tricitrate decahydrate
Drug Type	Small molecule
Drug Synonymous	tetraferric tricitrate decahydrate; ferric citrate hydrate; UNII-Q91187K011; DB14520; Q91187K011; Q22075864 Click to Show/Hide
Therapeutic Class	Phosphate Binders
Structure
Structure	3D Structure		2D Structure
Formula	C18H32Fe4O31
InChI	InChI=1S/3C6H7O7.4Fe.10H2O/c37-3(8)1-6(13,5(11)12)2-4(9)10;;;;;;;;;;;;;;/h31-2H2,(H,7,8)(H,9,10)(H,11,12);;;;;101H2/q3-1;4*+3;;;;;;;;;;/p-9
InChIKey	UISKQNNAQKPSDO-UHFFFAOYSA-E
Canonical SMILES	C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])[O-].C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])[O-].C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])[O-].O.O.O.O.O.O.O.O.O.O.[Fe+3].[Fe+3].[Fe+3].[Fe+3]
External Link
External Link	Pubchem ID	90478690

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM013 Competitive binding of plasma proteins BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Tetraferric tricitrate decahydrate
Affected gastrointestinal absorption
	Complex formation					Drug Num: 43
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0181		Bictegravir	C21H18F3N3O5	90311989	Major		Inter Info	[1], [2], [3]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Major		Inter Info	[7], [8]
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[10], [11], [12]
D0144		Baloxavir marboxil	C27H23F2N3O7S	124081896	Moderate		Inter Info	[1], [13]
D0277		Cefdinir	C14H13N5O5S2	6915944	Moderate		Inter Info	[14], [15]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[16], [17], [18]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[16], [17], [18]
D0433		Deferiprone	C7H9NO2	2972	Moderate		Inter Info	[19]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[16], [17], [18]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[20], [21], [22]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[20], [21], [22]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[2], [23]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[16], [17], [18]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[24], [25], [26]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[11], [27], [12]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[16], [17], [18]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[16], [17], [18]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[16], [17], [18]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[10], [11], [12]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[28], [29], [30]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[16], [17], [18]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[31], [32], [8]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[31], [32], [8]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[31], [32], [8]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[16], [17], [18]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[33], [34], [29]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[20], [21], [22]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[16], [17], [18]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[35]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[16], [17], [18]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[16], [17], [18]
D1175		Omadacycline	C29H40N4O7	54697325	Moderate		Inter Info	[20], [21], [22]
D1209		Oxytetracycline	C22H24N2O9	54675779	Moderate		Inter Info	[20], [21], [22]
D1245		Penicillamine	C5H11NO2S	5852	Moderate		Inter Info	[36], [37], [38]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[2], [39], [40]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[10], [11], [12]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[20], [21], [22]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[16], [17], [18]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[20], [21], [22]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[31], [32], [8]
D1584		Tiludronic acid	C7H9ClO6P2S	60937	Moderate		Inter Info	[11], [27], [12]
D1635		Triethylenetetramine	C6H18N4	5565	Moderate		Inter Info	[42]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[16], [17], [18]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0708		Gallium chloride Ga-67	Cl3Ga	73415785	Moderate		Inter Info	[41]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1776		Dimercaprol	C3H8OS2	3080	Major		Inter Info	[4], [5], [6]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[9]

References
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3	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
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7	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
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10	Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
11	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
12	Product Information. Skelid (tilundronate). Sanofi Winthrop Pharmaceuticals, New York, NY.
13	Product Information. Xofluza (baloxavir marboxil). Genentech, South San Francisco, CA.
14	Product Information. Omnicef (cefdinir). Parke-Davis, Morris Plains, NJ.
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19	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
20	Product Information. Auryxia (ferric citrate). Keryx Biopharmaceuticals, Inc., New York, NY.
21	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
22	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
23	Product Information. Promacta (eltrombopag). GlaxoSmithKline, Research Triangle Park, NC.
24	Product Information. Comtan (entacapone) Novartis Pharmaceuticals, East Hanover, NJ.
25	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
26	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
27	Product Information. Fosamax (alendronate). Merck &amp Co, Inc, West Point, PA.
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32	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
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39	Multum Information Services, Inc. Expert Review Panel.
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41	Product Information. Gallium Citrate Ga-67 (gallium citrate 67 Ga (gallium citrate 67Ga)). Bristol-Myers Squibb, Princeton, NJ.
42	Product Information. Syprine (trientine). Aton Pharma, Lawrenceville, NJ.

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