Drug General Information (ID: DDIKA40PQL)
Drug Name			Demeclocycline		Drug Info		Tetraferric tricitrate decahydrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Phosphate Binders
Structure

Mechanism of Demeclocycline-Tetraferric tricitrate decahydrate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Demeclocycline				Tetraferric tricitrate decahydrate
Mechanism		Binds to polyvalent cations				Polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Tetraferric tricitrate decahydrate due to formation of complexes caused by Demeclocycline

Recommended Action
Management		Doxycycline should be administered at least one hour before ferric citrate according to the manufacturer. Omadacycline administration with ferric citrate should be separated by 4 hours. No recommendations are available for coadministration with other tetracyclines.

References
1	Product Information. Auryxia (ferric citrate). Keryx Biopharmaceuticals, Inc., New York, NY.
2	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
3	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.