Details of Drug

Drug General Information (ID: D1558)
Drug Name	Testosterone
Drug Type	Small molecule
Drug Synonymous	AndroGel; Androderm; Androlin; Andronaq; Andropatch; Androsorb; Andrusol; Depotest; Halotensin; Homosteron; Homosterone; Intrinsa; LibiGel; Malerone; Mertestate; Neotestis; Oreton; Orquisteron; Perandren; Primotest; Primoteston; Relibra; Striant; Sustanon; Sustanone; Teslen; Testandrone; Testaqua; Testiculosterone; Testim; Testobase; Testoderm; Testogel; Testolin; Testopropon; Testosteroid; Testosteron; Testosterona; Testosteronum; Testostosterone; Testoviron; Testrone; Testryl; Virormone; Virosterone; Beta testosterone; Cristerona T; Cristerone T; Malogen in Oil; Oreton F; Percutacrine androgenique; Synandrol F; Testoderm Tts; Testopel Pellets; Testosterone and its esters; Testosterone hydrate; Testosterone solution; Testoviron Schering; Testoviron T; Testro AQ; Virilon IM; AA 2500; Andro 100; Andronate 100; Andronate 200; Andropository 200; Andryl 200; CDB 111C; CMC_13449; COL 1621; CP 601B; Everone 200; Sustason 250; Testamone 100; Testred Cypionate 200; Androderm (TN); Androgel (TN); Geno-cristaux gremy; Malestrone (amps); Malogen, aquaspension injection; Neo-Hombreol F; Neo-testis; Oreton-F; Scheinpharm Testone-Cyp; Striant (TN); T-Cypionate; Testim (TN); Testoject-50; Testosterona [INN-Spanish]; Testosterone [Androgenic steroids, anabolic]; Testosterone [INN:BAN]; Testosteronum [INN-Latin]; Trans-Testosterone; Testosterone (JAN/USP); Testrin-P.A; Delta4-Androsten-17beta-ol-3-one; Delta4-androsten-17b-ol-3-one; Androst-4-en-17beta-ol-3-one; Delta(sup 4)-Androsten-17(beta)-ol-3-one; (17beta)-17-Hydroxyandrost-4-en-3-one; (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; 17-Hydroxy-(17-beta)-androst-4-en-3-one; 17-Hydroxy-(17beta)-androst-4-en-3-one; 17-Hydroxy-4-androsten-3-one; 17-beta-Hydroxy-delta(sup 4)-androsten-3-one; 17-beta-Hydroxyandrost-4-en-3-one; 17b-hydroxy-4-androsten-3-one; 17beta-Hydroxy-3-oxo-4-androstene; 17beta-Hydroxy-4-androsten-3-one; 17beta-Hydroxy-delta(sup4)-androsten-3-one; 17beta-Hydroxyandrost-4-en-3-one; 17beta-Hydroxyandrost-4-ene-3-one; 4-Androsten-17-ol-3-one; 4-Androsten-17beta-ol-3-one; 4-androstene-17beta-ol-3-one; 7-beta-Hydroxyandrost-4-en-3-one Click to Show/Hide
Disease Class	FB83: Low bone mass disorder; 5A81: Testicular dysfunction; 5A60-5A61: Pituitary gland disorder
Therapeutic Class	Antiandrogens
Structure
Structure	3D Structure		2D Structure
Formula	C19H28O2
InChI	1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
InChIKey	MUMGGOZAMZWBJJ-DYKIIFRCSA-N
Canonical SMILES	CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C
External Link
	Pubchem ID	6013
	CAS Number	58-22-0
	CHEBI ID	17347
	TTD ID	D06XMU
	VARIDT ID	DR00108

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM047 Additive thrombogenic effects BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM083 Potentiated the pharmacological effects (Unspecific) BM108 Increased risk of hypercalcemia
Relation Graph

Full list of drugs interacting with Testosterone
Affected cellular transport
	Transporter inhibition					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1], [3], [9], [10]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[1], [3], [187]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[212]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[3], [214]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[228]
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[3], [183]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[129], [130], [131], [132], [133]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[153], [154]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[155]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[156]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[172]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[175], [176], [177]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[179]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[180], [181], [182]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[184], [185]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[188]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[196]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[198]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[199]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[200]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[201], [202]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[203]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[204]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[180], [181], [182]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[184], [185]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[215], [1], [216], [217], [218], [219], [220], [221], [222]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[223]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1], [3], [224]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[225]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[226]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[1], [3], [229], [230]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[232]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[233]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[3]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[244], [245]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[3], [246]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[249]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[251]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[252], [253]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[255]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[256]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1], [3], [266]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[272], [273], [274], [275], [276], [277]
	CYP450 enzyme induction					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[126]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1], [3], [173], [174]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1], [3], [178]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[190]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [197]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [205]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[206]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[207], [1], [3], [208]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[209]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[227]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[234], [235], [236]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[3], [237]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[241], [242]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[3], [243]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1], [3], [178]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1], [3], [248], [178]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[250]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[3], [254]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[267], [268], [269], [270], [271]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[267], [268], [269], [270], [271]
	Competitive inhibition of metabolic enzyme					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[1], [210], [211]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[1], [210], [211]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[247], [177]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[247], [177]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[247], [177]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[1], [2], [3]
D0385		Conestat alfa	NA	NA	Moderate		Inter Info	[192], [193], [194], [195]
D0762		Human C1-esterase inhibitor	NA	NA	Moderate		Inter Info	[192], [194], [195]
	Increased risk of hepatotoxicity					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[4], [5], [6]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[7]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[8]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[11]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[4], [5], [6]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[113], [114], [115], [1], [3], [116], [117], [118], [119], [120], [121], [122], [123]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [3], [134]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[164], [165], [166], [167]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[3], [171]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[113], [114], [115], [1], [3], [116], [117], [118], [119], [120], [121], [122], [123]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[113], [114], [115], [1], [3], [116], [117], [118], [119], [120], [121], [122], [123]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[186]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[113], [114], [115], [1], [3], [116], [117], [118], [119], [120], [121], [122], [123]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[3], [189]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[191]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[213]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[231]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[164], [165], [166], [167]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[1], [3], [238], [239], [240]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[257], [258]
	Increased risk of hypoglycemia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [157], [23], [24], [25], [26], [27], [28], [29], [30], [32], [33], [34], [36], [37], [38], [39], [41], [42], [43], [45], [47], [48], [49], [50], [51], [52], [53], [54], [55], [57], [60], [62], [63], [64], [67], [68], [70], [71], [72], [74], [158], [76], [159], [160], [81], [161], [162], [87], [89], [90], [91], [93], [95], [97], [99], [100], [104], [105], [106], [107], [163], [108], [109], [111], [112]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [76], [93]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [76], [93]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [76], [93]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [76], [93]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [76], [93]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[19], [76], [93]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [157], [23], [24], [25], [26], [27], [28], [29], [30], [32], [33], [34], [36], [37], [38], [39], [41], [42], [43], [45], [47], [48], [49], [50], [51], [52], [53], [54], [55], [57], [60], [62], [63], [64], [67], [68], [70], [71], [72], [74], [158], [76], [159], [160], [81], [161], [162], [87], [89], [90], [91], [93], [95], [97], [99], [100], [104], [105], [106], [107], [163], [108], [109], [111], [112]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[19], [76], [93]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[19], [76], [93]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[19], [76], [93]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [157], [23], [24], [25], [26], [27], [28], [29], [30], [32], [33], [34], [36], [37], [38], [39], [41], [42], [43], [45], [47], [48], [49], [50], [51], [52], [53], [54], [55], [57], [60], [62], [63], [64], [67], [68], [70], [71], [72], [74], [158], [76], [159], [160], [81], [161], [162], [87], [89], [90], [91], [93], [95], [97], [99], [100], [104], [105], [106], [107], [163], [108], [109], [111], [112]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [157], [23], [24], [25], [26], [27], [28], [29], [30], [32], [33], [34], [36], [37], [38], [39], [41], [42], [43], [45], [47], [48], [49], [50], [51], [52], [53], [54], [55], [57], [60], [62], [63], [64], [67], [68], [70], [71], [72], [74], [158], [76], [159], [160], [81], [161], [162], [87], [89], [90], [91], [93], [95], [97], [99], [100], [104], [105], [106], [107], [163], [108], [109], [111], [112]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [157], [23], [24], [25], [26], [27], [28], [29], [30], [32], [33], [34], [36], [37], [38], [39], [41], [42], [43], [45], [47], [48], [49], [50], [51], [52], [53], [54], [55], [57], [60], [62], [63], [64], [67], [68], [70], [71], [72], [74], [158], [76], [159], [160], [81], [161], [162], [87], [89], [90], [91], [93], [95], [97], [99], [100], [104], [105], [106], [107], [163], [108], [109], [111], [112]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[124], [125]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[168], [169], [170]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[168], [169], [170]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[124], [125]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[124], [125]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[124], [125]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[124], [125]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[124], [125]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[124], [125]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[168], [169], [170]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[124], [125]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[124], [125]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[124], [125]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[168], [169], [170]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[124], [125]
	Increased risk of hypercalcemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1754		Calcitriol (topical)	C27H44O3	5280453	Moderate		Inter Info	[127], [128]
D1753		Calcipotriol (topical)	C27H40O3	5288783	Moderate		Inter Info	[127], [128]

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120	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
121	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
122	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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155	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
156	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
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159	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
160	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
161	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
162	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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165	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
166	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
167	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
168	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
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172	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
173	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
174	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
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176	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
177	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
178	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
179	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
180	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
181	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
182	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
183	Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
184	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
185	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
186	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
187	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
188	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
189	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
190	Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
191	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
192	Product Information. Berinert (complement C1 esterase inhibitor). CSL Behring, King of Prussia, PA.
193	Product Information. Cinryze (complement C1 esterase inhibitor). ViroPharma Incorporated, Exton, PA.
194	Product Information. Ruconest (conestat alfa). Valeant Pharmaceuticals, Costa Mesa, CA.
195	Gandhi PK, Gentry WM, Bottorff MB "Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: investigation from the United States Food and Drug Administration adverse event reporting system database." Pharmacotherapy 32 (2012): 902-9. [PMID: 23033229]
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197	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
198	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
199	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
200	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
201	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
202	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
203	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
204	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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208	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
209	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
210	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
211	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
212	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
213	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
214	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
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223	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
224	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
225	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
226	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
227	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
228	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
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230	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
231	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
232	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
233	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
234	Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
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237	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
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240	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
241	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
242	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
243	Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
244	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
245	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
246	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
247	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
248	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
249	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
250	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
251	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
252	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
253	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
254	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
255	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
256	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
257	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
258	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
259	Burgess SJ, Singer GG, Brennan DC "Effect of troglitazone on cyclosporine whole blood levels." Transplantation 66 (1998): 272. [PMID: 9701278]
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264	Product Information. Rezulin (troglitazone). Parke-Davis, Morris Plains, NJ.
265	Terra SG, Washam JB, May DB "Comment: troglitazone drug interactions." Ann Pharmacother 32 (1998): 1111. [PMID: 9793611]
266	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
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268	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
269	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
270	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
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275	Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
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