Drug General Information (ID: DDIKBHC7AX)
Drug Name			Levothyroxine		Drug Info		Testosterone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antithyroid Agents				Antiandrogens
Structure

Mechanism of Levothyroxine-Testosterone Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Levothyroxine				Testosterone
Mechanism		Thyroid hormone				Increase the risk of hyperthyroidism in patients receiving thyroid hormone replacement therapy
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Levothyroxine and Testosterone

Recommended Action
Management		Clinical and laboratory monitoring of thyroid function may be necessary, as may a 25% to 50% reduction in thyroid hormone dosage.

References
1	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
2	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
3	Arafah BM "Decreased levothyroxine requirement in women with hypothyroidism during androgen therapy for breast cancer." Ann Intern Med 121 (1994): 247-51