Drug General Information (ID: DDIJSA2OY9)
Drug Name			Testosterone		Drug Info		Prednisone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiandrogens				Antiinflammatory Agents
Structure

Mechanism of Testosterone-Prednisone Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Testosterone				Prednisone
Mechanism		Steroidal effects Fluid retention				Steroidal effects Fluid retention
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Testosterone and Prednisone

Recommended Action
Management		Caution is advised if androgens are used in combination with ACTH or corticosteroids, particularly in patients with conditions that may be aggravated by fluid retention such as cardiovascular, renal, or hepatic diseases.

References
1	Product Information. AndroGel (testosterone). Unimed Pharmaceuticals, Buffalo Grove, IL.
2	Product Information. Oxandrin (oxandrolone). Bio-Tech, Levittown, PA.