Details of Drug

Drug General Information (ID: D1516)
Drug Name	Sulfamethoxazole
Drug Type	Small molecule
Drug Synonymous	sulfamethoxazole; 723-46-6; Gantanol; Sulphamethoxazole; Sulfisomezole; Sulfamethoxazol; Metoxal; Sulfamethylisoxazole; Simsinomin; Radonil; Sinomin; Sulphamethoxazol; 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide; Sulpha-methoxizole; Sulfamethalazole; Azo-gantanol; Sulphamethylisoxazole; Urobak; Sulfamethoxizole; 3-Sulfanilamido-5-methylisoxazole; Gantanol-DS; 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide; Bactrimel; Gamazole; Sulphisomezole; Sulfametoxazol; Solfametossazolo; Sulfamethoxazolum; Ro 4-2130; SMX; Septran; Sulphamethalazole; Trib; Solfametossazolo [DCIT]; Sulfamethoxazole sodium; MS 53; Sulphamethoxazole BP 98; ALBB-002089; Apo-Sulfamethoxazole; Bactrim (TN); Septra (TN); Septrin (TN); Sulfamethoxazolum [INN-Latin]; Sulfametoxazol [INN-Spanish]; Ro 6-2580/11; Ro-4-2130; Sulfamethoxazole [USAN:INN:JAN]; Sulfamethoxazole (JP15/USP/INN); N1-(5-Methyl-3-isoxazolyl)sulfanilamide; N1-(5-Methylisoxazol-3-yl)sulfanilamide; SULFAMETHOXAZOLE (8064-90-2 (TRIMETHOPRIM/SULFAMETHOXAZOLE); N'-(5-Methyl-3-isoxazole)sulfanilamide; N'-(5-Methyl-3-isoxazolyl)sulfanilamide; N'-(5-Methylisoxazol-3-yl)sulphanilamide; N(sup 1)-(5-Methyl-3-isoxazolyl)sulfanilamide; N(sup 1)-(5-Methyl-3-isoxazolyl)sulphanilamide; N(sup1)-(5-Methyl-3-isoxazolyl)sulfanilamide; Sulfanilamide, N1-(5-methyl-3-isoxazolyl)-(8CI); 3-(p-Aminophenylsulfonamido)-5-methylisoxazole; 3-(para-Aminophenylsulphonamido)-5-methylisoxazole; 3-Sulphanilamido-5-methylisoxazole; 4-Amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide; 4-Amino-N-[5-methyl-3-isoxazolyl]benzenesulfonamide; 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide; 5-Methyl-3-sulfanilamidoisoxazole; 5-Methyl-3-sulfanylamidoisoxazole; 5-Methyl-3-sulphanil-amidoisoxazole; Sulphameth oxazole Click to Show/Hide
Disease Class	1A00-1C4Z: Bacterial infection; 1F40-1F45: Malaria
Therapeutic Class	Antiinfective Agents
Structure
Structure	3D Structure		2D Structure
Formula	C10H11N3O3S
InChI	1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
InChIKey	JLKIGFTWXXRPMT-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N
External Link
	Pubchem ID	5329
	CAS Number	723-46-6
	CHEBI ID	9332
	TTD ID	D0R9OH
	INTEDE ID	DR1511
	VARIDT ID	DR01206

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM071 Increased risk of methemoglobinemia BM072 Increased risk of nephrotoxicity BM075 Increased risk of photosensitivity reactions BM076 Increased risk of prolong QT interval BM083 Potentiated the pharmacological effects (Unspecific) BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Sulfamethoxazole
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[188], [189]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[188], [189]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[9], [10], [11]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[9], [10], [11]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[31], [32], [33], [34], [9], [35], [36], [37], [38], [39], [10], [40], [41], [42], [43], [44], [45], [46], [11], [47], [48]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[171], [172], [3], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[247], [248], [36]
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[214]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[215], [216], [217]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[54]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[13], [3]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[18], [13], [191]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[211]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[13], [3], [212]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[218], [219], [220], [221]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[222], [223]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[224]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[232]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[236], [237], [238]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[239]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[240], [241]
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[205], [206], [207]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[13], [3], [225]
Pharmacodynamic additive effects
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[3], [4], [5]
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[20]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[23]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[27]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[55]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[56], [57]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[167], [168], [169], [170]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[167], [168], [169], [170]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[190]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[192], [193], [194], [13], [3], [195], [196], [197], [198], [199], [200], [201], [202]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[192], [193], [194], [13], [3], [195], [196], [197], [198], [199], [200], [201], [202]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[208]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[209]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[192], [193], [194], [13], [3], [195], [196], [197], [198], [199], [200], [201], [202]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[3], [210]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[213]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[167], [168], [169], [170]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[13], [3], [229], [230], [231]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[3], [233]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[234], [235]
	Increased risk of hypoglycemia					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[49], [50], [51]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[49], [50], [51]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [49], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [50], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [36], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [51], [152], [153], [154], [155], [156], [157], [158], [159]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [160], [74], [75], [49], [76], [77], [78], [79], [80], [82], [83], [84], [86], [87], [88], [89], [90], [91], [92], [94], [96], [97], [98], [99], [100], [101], [102], [103], [104], [106], [108], [110], [111], [112], [115], [116], [118], [119], [120], [122], [161], [124], [162], [163], [129], [164], [165], [135], [137], [138], [139], [141], [143], [145], [147], [148], [51], [152], [153], [154], [166], [155], [156], [158], [159]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [124], [141]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [124], [141]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [124], [141]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [124], [141]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [124], [141]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[70], [124], [141]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [160], [74], [75], [49], [76], [77], [78], [79], [80], [82], [83], [84], [86], [87], [88], [89], [90], [91], [92], [94], [96], [97], [98], [99], [100], [101], [102], [103], [104], [106], [108], [110], [111], [112], [115], [116], [118], [119], [120], [122], [161], [124], [162], [163], [129], [164], [165], [135], [137], [138], [139], [141], [143], [145], [147], [148], [51], [152], [153], [154], [166], [155], [156], [158], [159]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[70], [124], [141]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [49], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [50], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [36], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [51], [152], [153], [154], [155], [156], [157], [158], [159]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [49], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [50], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [36], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [51], [152], [153], [154], [155], [156], [157], [158], [159]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [49], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [50], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [36], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [51], [152], [153], [154], [155], [156], [157], [158], [159]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[70], [124], [141]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[70], [124], [141]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [160], [74], [75], [49], [76], [77], [78], [79], [80], [82], [83], [84], [86], [87], [88], [89], [90], [91], [92], [94], [96], [97], [98], [99], [100], [101], [102], [103], [104], [106], [108], [110], [111], [112], [115], [116], [118], [119], [120], [122], [161], [124], [162], [163], [129], [164], [165], [135], [137], [138], [139], [141], [143], [145], [147], [148], [51], [152], [153], [154], [166], [155], [156], [158], [159]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [160], [74], [75], [49], [76], [77], [78], [79], [80], [82], [83], [84], [86], [87], [88], [89], [90], [91], [92], [94], [96], [97], [98], [99], [100], [101], [102], [103], [104], [106], [108], [110], [111], [112], [115], [116], [118], [119], [120], [122], [161], [124], [162], [163], [129], [164], [165], [135], [137], [138], [139], [141], [143], [145], [147], [148], [51], [152], [153], [154], [166], [155], [156], [158], [159]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [160], [74], [75], [49], [76], [77], [78], [79], [80], [82], [83], [84], [86], [87], [88], [89], [90], [91], [92], [94], [96], [97], [98], [99], [100], [101], [102], [103], [104], [106], [108], [110], [111], [112], [115], [116], [118], [119], [120], [122], [161], [124], [162], [163], [129], [164], [165], [135], [137], [138], [139], [141], [143], [145], [147], [148], [51], [152], [153], [154], [166], [155], [156], [158], [159]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[49], [50], [51]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[49], [50], [51]
	Increased risk of methemoglobinemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1337		Prilocaine	C13H20N2O	4906	Major		Inter Info	[12], [13], [3], [14], [15], [16], [17]
D1338		Prilocaine (topical)	C13H20N2O	4906	Major		Inter Info	[18], [13], [17]
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[24], [25], [26]
D1344		Procaine	C13H20N2O2	4914	Moderate		Inter Info	[3]
D0319		Chloroprocaine	C13H19ClN2O2	8612	Moderate		Inter Info	[3]
D1561		Tetracaine	C15H24N2O2	5411	Moderate		Inter Info	[3]
	Increased risk of nephrotoxicity					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[6], [7], [8]
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[13], [3]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[13], [3]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[13], [3]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[13], [3]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[1], [2]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[13], [3], [52]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[13], [185], [1], [186], [187]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[13], [3], [52]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[203], [3], [204]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[3], [185], [1], [242]
	Increased risk of prolong QT interval					Drug Num: 183
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Minor		Inter Info	[18], [13], [243]
D0036		Alfuzosin	C19H27N5O4	2092	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0068		Amitriptyline	C20H23N	2160	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0072		Amoxapine	C17H16ClN3O	2170	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0097		Apomorphine	C17H17NO2	6005	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0115		Astemizole	C28H31FN4O	2247	Minor		Inter Info	[18], [13], [243]
D0119		Atomoxetine	C17H21NO	54841	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0139		Azithromycin	C38H72N2O12	447043	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0219		Buprenorphine	C29H41NO4	644073	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0320		Chloroquine	C18H26ClN3	2719	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0324		Chlorpromazine	C17H19ClN2S	2726	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0342		Cisapride	C23H29ClFN3O4	6917698	Minor		Inter Info	[18], [13], [243]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0358		Clofazimine	C27H22Cl2N4	2794	Minor		Inter Info	[18], [13], [243]
D0429		Daunorubicin	C27H29NO10	30323	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Minor		Inter Info	[18], [13], [243]
D0467		Dextropropoxyphene	C22H29NO2	10100	Minor		Inter Info	[18], [13], [243]
D0508		Disopyramide	C21H29N3O	3114	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0513		Dofetilide	C19H27N3O5S2	71329	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0514		Dolasetron	C19H20N2O3	3033818	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0528		Doxorubicin	C27H29NO11	31703	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Minor		Inter Info	[18], [13], [243]
D0535		Droperidol	C22H22FN3O2	3168	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0584		Epirubicin	C27H29NO11	41867	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0636		Famotidine	C8H15N7O2S3	5702160	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0676		Fluoxetine	C17H18F3NO	3386	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0678		Fluphenazine	C22H26F3N3OS	3372	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0682		Flutamide	C11H11F3N2O3	3397	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0694		Foscarnet	CH3O5P	3415	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0737		Goserelin	C59H84N18O14	5311128	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0738		Granisetron	C18H24N4O	5284566	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[18], [13], [243]
D0750		Haloperidol	C21H23ClFNO2	3559	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0787		Ibutilide	C20H36N2O3S	60753	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0795		Imipramine	C19H24N2	3696	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0908		Leuprolide	C59H84N16O12	657181	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[18], [13], [243]
D0979		Maprotiline	C20H23N	4011	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0992		Mefloquine	C17H16F6N2O	4046	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1010		Mesoridazine	C21H26N2OS2	4078	Minor		Inter Info	[18], [13], [243]
D1017		Methadone	C21H27NO	4095	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1063		Mifepristone	C29H35NO2	55245	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1075		Mirtazapine	C17H19N3	4205	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1137		Nilutamide	C12H10F3N3O4	4493	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1158		Nortriptyline	C19H21N	4543	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1166		Olanzapine	C17H20N4S	135398745	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1181		Ondansetron	C18H19N3O	4595	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1210		Oxytocin	C43H66N12O12S2	439302	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1216		Palonosetron	C19H24N2O	6337614	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1246		Pentamidine	C19H24N4O2	4735	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1254		Perflutren	C3F8	6432	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1257		Perphenazine	C21H26ClN3OS	4748	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1346		Prochlorperazine	C20H24ClN3S	4917	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1351		Promazine	C17H20N2S	4926	Minor		Inter Info	[18], [13], [243]
D1356		Propofol	C12H18O	4943	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1361		Protriptyline	C19H21N	4976	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1371		Quinidine	C20H24N2O2	441074	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1372		Quinine	C20H24N2O2	3034034	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1413		Risperidone	C23H27FN4O2	5073	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1438		Salbutamol	C13H21NO3	2083	Minor		Inter Info	[18], [13], [243]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1498		Sotalol	C12H20N2O3S	5253	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0007		Abiraterone	C24H31NO	132971	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0037		Alimemazine	C18H22N2S	5574	Minor		Inter Info	[18], [13], [243]
D0066		Amiodarone	C25H29I2NO3	2157	Minor		Inter Info	[243], [244], [245], [246]
D0067		Amisulpride	C17H27N3O4S	2159	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0107		Arsenic trioxide	As2O3	14888	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0112		Asenapine	C17H16ClNO	3036780	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0170		Bepridil	C24H34N2O	2351	Minor		Inter Info	[18], [13], [243]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0230		Cabozantinib	C28H24FN3O5	25102847	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0336		Cilostazol	C20H27N5O2	2754	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0361		Clomipramine	C19H23ClN2	2801	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0437		Degarelix	C82H103ClN18O16	16136245	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0446		Desipramine	C18H22N2	2995	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0452		Deutetrabenazine	C19H27NO3	73437646	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0526		Doxepin (topical)	C19H21NO	667477	Minor		Inter Info	[18], [13], [243]
D0534		Dronedarone	C31H44N2O5S	208898	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0577		Entrectinib	C31H34F2N6O2	25141092	Minor		Inter Info	[18], [13], [243]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0594		Eribulin	C40H59NO11	11354606	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0632		Ezogabine	C16H18FN3O2	121892	Minor		Inter Info	[18], [13], [243]
D0661		Fingolimod	C19H33NO2	107970	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0664		Flecainide	C17H20F6N2O3	3356	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[18], [13], [243]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0720		Gilteritinib	C29H44N8O3	49803313	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0725		Glasdegib	C21H22N6O	25166913	Minor		Inter Info	[18], [13], [243]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Minor		Inter Info	[18], [13], [243]
D0751		Halothane	C2HBrClF3	3562	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0758		Histrelin	C66H86N18O12	25077993	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0788		Idarubicin	C26H27NO9	42890	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0791		Iloperidone	C24H27FN2O4	71360	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0806		Inotuzumab ozogamicin	NA	NA	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Minor		Inter Info	[18], [13], [243]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0899		Lefamulin	C28H45NO5S	25185057	Minor		Inter Info	[18], [13], [243]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0909		Levacetylmethadol	C23H31NO2	15130	Minor		Inter Info	[18], [13], [243]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0940		Lithium carbonate	CLi2O3	11125	Minor		Inter Info	[18], [13], [243]
D0942		Lofexidine	C11H12Cl2N2O	30668	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Minor		Inter Info	[18], [13], [243]
D0965		Macimorelin	C26H30N6O3	9804938	Minor		Inter Info	[18], [13], [243]
D1026		Methotrimeprazine	C19H24N2OS	72287	Minor		Inter Info	[18], [13], [243]
D1062		Midostaurin	C35H30N4O4	9829523	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1136		Nilotinib	C28H22F3N7O	644241	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[18], [13], [243]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1169		Oliceridine	C22H30N2O2S	66553195	Minor		Inter Info	[18], [13], [243]
D1171		Olodaterol	C21H26N2O5	11504295	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1189		Osilodrostat	C13H10FN3	44139752	Minor		Inter Info	[18], [13], [243]
D1190		Osimertinib	C28H33N7O2	71496458	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1211		Ozanimod	C23H24N4O3	52938427	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1215		Paliperidone	C23H27FN4O3	115237	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1221		Panobinostat	C21H23N3O2	6918837	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1230		Pasireotide	C58H66N10O9	9941444	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1232		Pazopanib	C21H23N7O2S	10113978	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1290		Pimavanserin	C25H34FN3O2	10071196	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1292		Pimozide	C28H29F2N3O	16362	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1302		Pitolisant	C17H26ClNO	9948102	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1339		Primaquine	C15H21N3O	4908	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1342		Probucol	C31H48O2S2	4912	Minor		Inter Info	[18], [13], [243]
D1343		Procainamide	C13H21N3O	4913	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1352		Promethazine	C17H20N2S	4927	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1353		Propafenone	C21H27NO3	4932	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1368		Quetiapine	C21H25N3O2S	5002	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1388		Relugolix	C29H27F2N7O5S	10348973	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1398		Ribociclib	C23H30N8O	44631912	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1404		Rilpivirine	C22H18N6	6451164	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1424		Romidepsin	C24H36N4O6S2	5352062	Minor		Inter Info	[18], [13], [243]
D1444		Saquinavir	C38H50N6O5	441243	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1459		Selpercatinib	C29H31N7O3	134436906	Minor		Inter Info	[18], [13], [243]
D1461		Sertraline	C17H17Cl2N	68617	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1463		Sevoflurane	C4H3F7O	5206	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1474		Siponimod	C29H35F3N2O3	44599207	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1491		Solifenacin	C23H26N2O2	154059	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Minor		Inter Info	[18], [13], [243]
D1522		Sunitinib	C22H27FN4O2	5329102	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1560		Tetrabenazine	C19H27NO3	6018	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Minor		Inter Info	[18], [13], [243]
D1651		Triptorelin	C64H82N18O13	25074470	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1673		Valbenazine	C24H38N2O4	24795069	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1533		Tamoxifen	C26H29NO	2733526	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[18], [13], [243]
D1554		Terbutaline	C12H19NO3	5403	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1555		Terfenadine	C32H41NO2	5405	Minor		Inter Info	[18], [13], [243]
D1574		Thioridazine	C21H26N2S2	5452	Minor		Inter Info	[18], [13], [243]
D1596		Tizanidine	C9H8ClN5S	5487	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1612		Toremifene	C26H28ClNO	3005573	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1616		Tramadol	C16H25NO2	33741	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1624		Trazodone	C19H22ClN5O	5533	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1637		Trifluoperazine	C21H24F3N3S	5566	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1638		Triflupromazine	C18H19F3N2S	5568	Minor		Inter Info	[18], [13], [243]
D1647		Trimipramine	C20H26N2	5584	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1683		Vasopressin	C46H65N15O12S2	644077	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1689		Venlafaxine	C17H27NO2	5656	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[18], [13], [3], [243], [244], [245], [246]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1366		Pyrimethamine	C12H13ClN4	4993	Moderate		Inter Info	[3], [185]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1020		Methenamine	C6H12N4	4101	Major		Inter Info	[21], [22]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[3], [28], [29]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[30]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0059		Aminobenzoic acid	C7H7NO2	978	Major		Inter Info	[19]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[53]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[58], [59], [60]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[58], [59], [60]
D0688		Folic acid	C19H19N7O6	135398658	Moderate		Inter Info	[3], [61], [62]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[58], [59], [60]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[226], [227], [228]

References
1	Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
2	Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
5	Canadian Pharmacists Association "e-CPS."
6	Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50. [PMID: 2683269]
7	Ringden O, Myrenfors P, Klintmalm G, Tyden G, Ost L "Nephrotoxicity by co-trimoxazole and cyclosporin in transplanted patients." Lancet 1 (1984): 1016-7.[PMID: 6143932]
8	Berg K, Gjellestad A, Nordby G, et al "Renal effects of trimethoprim in ciclosporin- and azathioprine-treated kidney-allografted patients." Nephron 53 (1989): 218-22.[PMID: 2677807]
9	Hermida J, Zarza J, Alberca I, et al. "Differential effects of 2C93 and 2C92 variants of cytochrome P-450 CYP2C9 on sensitivity to acenocoumarol." Blood 99 (2002): 4237-9. [PMID: 12010835]
10	O'Reilly RA, Motley CH "Racemic warfarin and trimethoprim-sulfamethoxazole interaction in humans." Ann Intern Med 91 (1979): 34-6. [PMID: 464451]
11	Venkatakrishnan K, vonMoltke LL, Greenblatt DJ "Effects of the antifungal agents on oxidative drug metabolism - Clinical relevance." Clin Pharmacokinet 38 (2000): 111-80. [PMID: 10709776]
12	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
13	Cerner Multum, Inc. "Australian Product Information.".
14	Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
15	Product Information. Citanest Forte (epinephrine-prilocaine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
16	Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
17	Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
18	Canadian Pharmacists Association.
19	Product Information. Potaba (potassium aminobenzoate). Glenwood Inc, Englewood, NJ.
20	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
21	Product Information. Hiprex (methenamine). Hoechst Marion-Roussel Inc, Kansas City, MO.
22	Product Information. Urised (methenamine). Polymedica Pharmaceuticals USA Inc, Woburn, MA.
23	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
24	Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
25	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
26	Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
27	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
28	UK government "Typhoid.".
29	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
30	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
31	Cook DE, Ponte CD "Suspected trimethoprim sulfamethoxazole induced hypoprothrombinemia." J Fam Pract 39 (1994): 589-91. [PMID: 7798864]
32	Fischer HD, Juurlink DN, Mamdani MM, Kopp A, Laupacis A "Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study." Arch Intern Med 170 (2010): 617-21. [PMID: 20386005]
33	Glasheen JJ, Fugit RV, Prochazka AV "The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens." J Gen Intern Med 20 (2005): 653-6. [PMID: 16050864]
34	Hermans JJ, Thijssen HH "Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics." Br J Pharmacol 110 (1993): 482-90. [PMID: 8220911]
35	Kelly JG, O'Malley K "Clinical pharmacokinetics of oral anticoagulants." Clin Pharmacokinet 4 (1979): 1-15. [PMID: 369763]
36	Lumholtz B, Siersbaek-Nielsen K, Skovsted L, Kampmann J, Hansen JM "Sulfamethizole-induced inhibition of diphenylhydantoin, tolbutamide, and warfarin metabolism." Clin Pharmacol Ther 17 (1975): 731-4. [PMID: 1139863]
37	Miners JO, Birkett DJ "Cytochrome P4502C9: an enzyme of major importance in human drug metabolism." Br J Clin Pharmacol 45 (1998): 525-38. [PMID: 9663807]
38	O'Donnell D "Antibiotic-induced potentiation of oral anticoagulant agents." Med J Aust 150 (1989): 163-4. [PMID: 2716588]
39	O'Reilly RA "Stereoselective interaction of trimethoprim-sulfamethaxazole with the separated enantiomorphs of racemic warfarin in man." N Engl J Med 302 (1980): 33-5. [PMID: 7350395]
40	Penning-van Beest F, Erkens J, Petersen KU, Koelz HR, Herings R "Main comedications associated with major bleeding during anticoagulant therapy with coumarins." Eur J Clin Pharmacol 61 (2005): 439-44. [PMID: 15947920]
41	Penning-van Beest FJ, van Meegen E, Rosendaal FR, Stricker BH "Drug interactions as a cause of overanticoagulation on phenprocoumon or acenocoumarol predominantly concern antibacterial drugs." Clin Pharmacol Ther 69 (2001): 451-7. [PMID: 11406743]
42	Self TH, Evans W, Ferguson T "Interaction of sulfisoxizole and warfarin." Circulation 52 (1975): 528. [PMID: 1157265]
43	Serlin MJ, Breckenridge AM "Drug interactions with warfarin." Drugs 25 (1983): 610-20. [PMID: 6347619]
44	Sioris LJ, Weibert RT, Pentel PR "Potentiation of warfarin anaticoagulation by sulfisoxazole." Arch Intern Med 140 (1980): 546-7. [PMID: 7362390]
45	Takahashi H, Wilkinson GR, Caraco Y, et al. "Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients." Clin Pharmacol Ther 73 (2003): 253-63. [PMID: 12621390]
46	Thijssen HH, Flinois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Disposition 28 (2000): 1284-90. [PMID: 11038154]
47	Visser LE, Penning-Van Bees FJ, Harrie Kasbergen AA, et al. "Overanticoagulation associated with combined use of antibacterial drugs and acenocoumarol or phenprocoumon anticoagulants." Thromb Haemost 88 (2002): 705-10. [PMID: 12428081]
48	Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83. [PMID: 7944078]
49	Christensen LK, Hansen JM, Kristensen M "Sulphaphenazole-induced hypoglycemic attacks in tolbutamide-treated diabetics." Lancet 2 (1963): 1298-301. [PMID: 14071924]
50	Field JB, Ohta M, Boyle C, Remer A "Potentiation of acetohexamide hypoglycemia by phenylbutazone." N Engl J Med 277 (1967): 889-94. [PMID: 6061822]
51	Turtle JR, Burgess JA "Hypoglycemic action of fenfluramine in diabetes mellitus." Diabetes 22 (1973): 858-67. [PMID: 4749404]
52	Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
53	Product Information. Colazal (balsalazide) Salix Pharmaceuticals, Palo Alto, CA.
54	Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
55	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
56	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
57	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
58	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
59	Barnett ML "Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration." J Periodontol 56 (1985): 18-20. [PMID: 3882930]
60	King VJ "OC failure rates and oral antibiotics." J Fam Pract 45 (1997): 104-5. [PMID: 9267366]
61	Mulenga M, Malunga P, Bennett S. et.al "Folic acid treatment of Zambian children with moderate to severe malaria anemia." Am J Trop Med Hyg 74 (2006): 986-90
62	Product Information. Folic Acid (folic acid). Method Pharmaceuticals, LLC, Arlington, TX.
63	Abad S, Moachon L, Blanche P, Bavoux F, Sicard D, Salmon-Ceron D "Possible interaction between glicazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia." Br J Clin Pharmacol 52 (2001): 456-7. [PMID: 11678792]
64	Ahmad S "Drug interaction induces hypoglycemia." J Fam Pract 40 (1995): 540-1. [PMID: 7775905]
65	Ahmad S "Gemfibrozil: interaction with glyburide." South Med J 84 (1991): 102. [PMID: 1898783]
66	Aleyassine H, Gardiner RJ "Dual action of antidepressant drugs (MAO inhibitors) on insulin release." Endocrinology 96 (1975): 702-10. [PMID: 1090438]
67	Aleyassine H, Lee SH "Inhibition of insulin release by substrates and inhibitors of monoamine oxidase." Am J Physiol 222 (1972): 565-9. [PMID: 5022664]
68	Almirall J, Montoliu J, Torras A, Revert L "Propoxyphene-induced hypoglycemia in a patient with chronic renal failure." Nephron 53 (1989): 273-5. [PMID: 2797348]
69	Arauz-Pacheco C, Ramirez LC, Rios JM, Raskin P "Hypoglycemia induced by angiotensin-converting enzyme inhibitors in patients with non-insulin-dependent diabetes receiving sulfonylurea therapy." Am J Med 89 (1990): 811-3. [PMID: 2123605]
70	Asplund K, Wiholm BE, Lithner F "Glibenclamide-associated hypoglycaemia: a report on 57 cases." Diabetologia 24 (1983): 412-7. [PMID: 6411511]
71	Baciewicz AM, Swafford WB Jr "Hypoglycemia induced by the interaction of chlorpropamide and co-trimoxazole." Drug Intell Clin Pharm 18 (1984): 309-10. [PMID: 6609055]
72	Barbato M "Another problem with Kinidin." Med J Aust 141 (1984): 685. [PMID: 6436654]
73	Baron SH "Salicylates as hypoglycemic agents." Diabetes Care 5 (1982): 64-71. [PMID: 6754304]
74	Cacoub P, Deray G, Baumelou A, Grimaldi A, Soubrie C, Jacobs C "Disopyramide-induced hypoglycemia: case report and review of the literature." Fundam Clin Pharmacol 3 (1989): 527-35. [PMID: 2691378]
75	Cattaneo AG, Caviezel F, Pozza G "Pharmacological interaction between tolbutamide and acetylsalicylic acid: study on insulin secretion in man." Int J Clin Pharmacol Ther Toxicol 28 (1990): 229-34. [PMID: 2198232]
76	Cooper AJ, Ashcroft G "Potentiation of insulin hypoglycaemia by M.A.O.I. antidepressant drugs." Lancet 1 (1966): 407-9. [PMID: 4159787]
77	Croxson MS, Shaw DW, Henley PG, Gabriel HDLL "Disopyramide-induced hypoglycaemia and increased serum insulin." N Z Med J July (1987): 407-8. [PMID: 3330586]
78	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
79	Daubresse JC, Daigneux D, Bruwier M, Luyckx A, Lefebvre PJ "Clofibrate and diabetes control in patients treated with oral hypoglycaemic agents." Br J Clin Pharmacol 7 (1979): 599-603. [PMID: 380614]
80	Daubresse JC, Luyckx AS, Lefebvre PJ "Potentiation of hypoglycemic effect of sulfonylureas by clofibrate." N Engl J Med 294 (1976): 613. [PMID: 1246250]
81	David DS, Steere AC Jr, Pi-Sunyer XF, Sakai S, Clark SB "Aspirin-induced hypoglycaemia in a patient on haemodialysis." Lancet 2 (1971): 1092-3. [PMID: 4106934]
82	Davis TM, Karbwang J, Looareesuwan S, et al "Comparative effects of quinine and quinidine on glucose metabolism in healthy volunteers." Br J Clin Pharmacol 30 (1990): 397-403. [PMID: 2223418]
83	de Salcedo I, Gorringe AL, Silva JL, Santos JA "Gemfibrozil in a group of diabetics." Proc R Soc Med 69 (1976): 64-70. [PMID: 1019155]
84	Deeg MA, Lipkin EW "Hypoglycemia associated with the use of fluoxetine." West J Med 164 (1996): 262-3. [PMID: 8775944]
85	Diwan PV, Sastry MS, Satyanarayana NV "Potentiation of hypoglycemic response of glibenclamide by piroxicam in rats and humans." Indian J Exp Biol 30 (1992): 317-9. [PMID: 1459600]
86	Feher MD, Amiel S "ACE inhibitors and hypoglycaemia." Lancet 346 (1995): 125-6. [PMID: 7603199]
87	Feldman JM, Chapman B "Monoamine oxidase inhibitors: nature of their interaction with rabbit pancreatic islets to alter insulin secretion." Diabetologia 11 (1975): 487-94. [PMID: 1107123]
88	Ferrari C, Fressati S, Romussi M, et al. "Effects of short-term clofibrate administration on glucose tolerance and insulin secretion in patients with chemical diabetes or hypertriglyceridemia." Metabolism 26 (1977): 129-39. [PMID: 834147]
89	Ferriere M, Lachkar H, Richard JL, Bringer J, Orsetti A, Mirouze J "Captopril and insulin sensitivity." Ann Intern Med 102 (1985): 134-5. [PMID: 3881067]
90	Fogari R, Zoppi A, Corradi L, Pierangelo L, Mugellini A, Lusardi P "Comparative effects of lisinopril and losartan on insulin sensitivity in the treatment of non diabetic hypertension." Br J Clin Pharmacol 46 (1998): 467-71. [PMID: 9833600]
91	Giugliano D, Ceriello A, Saccomanno F, et al "Effects of salicylate, tolbutamide, and prostaglandin E2 on insulin responses to glucose in noninsulin-dependent diabetes mellitus." J Clin Endocrinol Metab 61 (1985): 160-6. [PMID: 3923028]
92	Goldberg IJ, Brown LK, Rayfield EJ "Disopyramide (norpace)-induced hypoglycemia." Am J Med 69 (1980): 463-6. [PMID: 6998294]
93	Harris EL "Adverse reactions to oral antidiabetic agents." Br Med J 3 (1971): 29-30. [PMID: 5091891]
94	Harrison LC, King-Roach A, Martin FI, Melick RA "The effect of fenfluramine on insulin binding and on basal and insulin-stimulated oxidation of 1-C-glucose by human adipose tissue." Postgrad Med J 51 Suppl 1 (1975): 110-4. [PMID: 1219664]
95	Hartmann D, Korn A, Komjati M, Heinz G, Haefelfinger P, Defoin R, Waldhausl WK "Lack of effect of tenoxicam on dynamic responses to concurrent oral doses of glucose and glibenclamide." Br J Clin Pharmacol 30 (1990): 245-52. [PMID: 2119677]
96	Hayashi S, Horie M, Tsuura Y, Ishida H, Okada Y, Seino Y, Sasayama S "Disopyramide blocks pancreatic ATP-sensitive K+ channels and enhances insulin release." Am J Physiol 265 (1993): c337-42. [PMID: 8368263]
97	Hekimsoy Z, Biberoglu S, Comlekci A, Tarhan O, Mermut C, Biberoglu K "Trimethoprim/sulfamethoxazole-induced hypoglycemia in a malnourished patient with severe infection." Eur J Endocrinol 136 (1997): 3046. [PMID: 9100556]
98	Hellman B "Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells." Metabolism 23 (1974): 839-46. [PMID: 4212254]
99	Herings RMC, Deboer A, Stricker BHC, Leufkens HGM, Porsius A "Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme." Lancet 345 (1995): 1195-8. [PMID: 7739305]
100	Hundal RS, Petersen KF, Mayerson AB, et al "Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes." J Clin Invest 109 (2002): 1321-6. [PMID: 12021247]
101	Iida H, Morita T, Suzuki E, Iwasawa K, Toyooka T, Nakajima T "Hypoglycemia induced by interaction between clarithromycin and disopyramide." Jpn Heart J 40 (1999): 91-6. [PMID: 10370402]
102	Johnson J, Dobmeier M "Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction." DICP 24 (1990): 250-1. [PMID: 2316232]
103	Johnson JA, Kappel JE, Sharif MN "Hypoglycemia secondary to trimethoprim/sulfamethoxazole administration in a renal transplant patient." Ann Pharmacother 27 (1993): 304-6. [PMID: 8453166]
104	Konttinen A, Kuisma I, Ralli R, Pohjola S, Ojala K "The effect of gemfibrozil on serum lipids in diabetic patients." Ann Clin Res 11 (1979): 240-5. [PMID: 398183]
105	Kradjan WA, Witt DM, Opheim KE, Wood FC "Lack of interaction between glipizide and co-trimoxazole." J Clin Pharmacol 34 (1994): 997-1002. [PMID: 7836551]
106	Kubacka RT, Antla EJ, Juhl RP, Welshman IR "Effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects." Ann Pharmacother 30 (1996): 20-6. [PMID: 8773160]
107	Lozada A, Dujovne CA "Drug interactions with fibric acids." Pharmacol Ther 63 (1994): 163-76. [PMID: 7809177]
108	Morris AD, Newton RW, Boyle DI, et al. "ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes." Diabetes Care 20 (1997): 1363-7. [PMID: 9283780]
109	Morrison PJ, Rogers HJ, Spector RG, Bradbrook ID, John VA "Effect of pirprofen on glibenclamide kinetics and response." Br J Clin Pharmacol 14 (1982): 123-6. [PMID: 6809024]
110	Murakami K, Nambu S, Koh H, Kobayashi M, Shigeta Y "Clofibrate enhances the affinity of insulin receptors in non-insulin dependent diabetes mellitus." Br J Clin Pharmacol 17 (1984): 89-91. [PMID: 6362704]
111	Nakabayashi H, Ito T, Igawa T, Hiraiwa Y, Imamura T, Seta T, Kawato M, Usukura N, Takeda R "Disopyramide induces insulin secretion and plasma glucose diminution: studies using the in situ canine pancreas." Metabolism 38 (1989): 179-83. [PMID: 2643753]
112	Nappi JM, Dhanani S, Lovejoy JR, VanderArk C "Severe hypoglycemia associated with disopyramide." West J Med 138 (1983): 95-7. [PMID: 6404062]
113	Niemi M, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ, Kivisto KT "Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride." Clin Pharmacol Ther 69 (2001): 194-200. [PMID: 11309547]
114	Nikkila EA, Ylikahri R, Huttunen JK "Gemfibrozil: effect on serum lipids, lipoproteins, postheparin plasma lipase activities and glucose tolerance in primary hypertriglyceridaemia." Proc R Soc Med 69 (1976): 58-63. [PMID: 190608]
115	Paolisso G, Balbi V, Gambardella A, Varricchio G, Tortoriello R, Saccomanno F, Amato L, Varricchio M "Lisinopril administration improves insulin action in aged patients with hypertension." J Hum Hypertens 9 (1995): 541-6. [PMID: 7562882]
116	Pestell RG, Crock PA, Ward GM, Alford FP, Best JD "Fenfluramine increases insulin action in patients with NIDDM." Diabetes Care 12 (1989): 252-8. [PMID: 2495916]
117	Petitpierre B, Perrin L, Rudhardt M, et al "Behaviour of chlorpropamide in renal insufficiency and under the effect of associated drug therapy." Int J Clin Pharmacol 6 (1972): 120-4. [PMID: 4638970]
118	Phillips AF, Matty PJ, Porte PJ, Raye JR "Inhibition of glucose-induced insulin secretion by indomethacin and sodium salicylate in the fetal lamb." Am J Obstet Gynecol 148 (1984): 481-7. [PMID: 6364813]
119	Phillips RE, Looareesuwan S, White NJ, et al "Hypoglycaemia and antimalarial drugs: quinidine and release of insulin." Br Med J 292 (1986): 1319-21. [PMID: 3085830]
120	Pollak PT, Mukherjee SD, Fraser AD "Sertraline-induced hypoglycemia." Ann Pharmacother 35 (2001): 1371-4. [PMID: 11724085]
121	Pond SM, Birkett DJ, Wade DN "Mechanisms of inhibition of tolbutamide metabolism: phenylbutazone, oxyphenbutazone, sulfaphenazole." Clin Pharmacol Ther 22 (1977): 573-9. [PMID: 913025]
122	Prince RL, Larkins RG, Alford FP "The effect of acetylsalicylic acid on plasma glucose and the response of glucose regulatory hormones to intravenous glucose and arginine in insulin treated diabetics and normal subjects." Metabolism 30 (1981): 293-8. [PMID: 7010074]
123	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
124	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
125	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
126	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
127	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
128	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
129	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
130	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
131	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
132	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
133	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
134	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
135	Quevedo SF, Krauss DS, Chazan JA, et al "Fasting hypoglycemia secondary to disopyramide therapy." JAMA 245 (1981): 2424. [PMID: 6785461]
136	Ravic M, Johnston A, Turner P "Clinical pharmacological studies of some possible interactions of lornoxicam with other drugs." Postgrad Med J 66 (1990): s30-4. [PMID: 2126624]
137	Richardson T, Foster J, Mawer GE "Enhancement by sodium salicylate of the blood glucose lowering effect of chlorpropamide-drug interaction or summation of similar effects." Br J Clin Pharmacol 22 (1986): 43-8. [PMID: 3527244]
138	Rubin M, Zakheim B, Pitchumoni C "Disopyramide-induced profound hypoglycemia." N Y State J Med July,Aug,S (1983): 1057-8. [PMID: 6579404]
139	Salmela PI, Sotaniemi EA, Viikari J, et al "Fenfluramine therapy in non-insulin-dependent diabetic patients effects on body weight, glucose homeostasis, serum lipoproteins, and antipyrine metabolism." Diabetes Care 4 (1981): 535-40. [PMID: 6751729]
140	Sawka AM, Burgart V, Zimmerman D "Loss of awareness of hypoglycemia temporally associated with selective serotonin reuptake inhibitors." Diabetes Care 24 (2001): 1845-6. [PMID: 11574457]
141	Semel JD, Wortham E, Karl DM "Fasting hypoglycemia associated with disopyramide." Am Heart J 106 (1983): 1160-1. [PMID: 6356848]
142	Shah SJ, Bhandarkar SD, Satoskar RS "Drug interaction between chlorpropamide and non-steroidal anti-flammatory drugs, ibuprofen and phenylbutazone." Int J Clin Pharmacol Ther Toxicol 22 (1984): 470-2. [PMID: 6500764]
143	Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V "Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia." Eur J Clin Nutr 57 (2003): 243-8. [PMID: 12571655]
144	Sjoberg S, Wiholm BE, Gunnarsson R, Emilsson H, Thunberg E, Christenson I, Ostman J "Lack of pharmacokinetic interaction between glibenclamide and trimethoprim-sulphamethoxazole." Diabet Med 4 (1987): 245-7. [PMID: 2956028]
145	Slade IH, and Iosefa RN "Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases." J Am Geriatr Soc 15 (1967): 948-50. [PMID: 6046558]
146	Sone H, Takahashi A, Yamada N "Ibuprofen-related hypoglycemia in a patient receiving sulfonylurea." Ann Intern Med 134 (2001): 344. [PMID: 11182854]
147	Storlien LH, Thorburn AW, Smythe GA, Jenkins AB, Chisholm DJ, Kraegen EW "Effect of d-fenfluramine on basal glucose turnover and fat-feeding-induced insulin resistance in rats." Diabetes 38 (1989): 499-503. [PMID: 2647557]
148	Strathman I, Schubert EN, Cohen A, Nitzberg DM "Hypoglycemia in patients receiving disopyramide phosphate." Drug Intell Clin Pharm 17 (1983): 635-8. [PMID: 6413187]
149	Tannenbaum H, Anderson LG, Soeldner JS "Phenylbutazone-tolbutamide drug interaction." N Engl J Med 290 (1974): 344. [PMID: 4809290]
150	Tran PO, Gleason CE, Robertson RP "Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function." Diabetes 51 (2002): 1772-8. [PMID: 12031964]
151	Tremaine LM, Wilner KD, Preskorn SH "A study of the potential effect of sertraline on the pharmacokinetics and protein binding of tolbutamide." Clin Pharmacokinet 32(Suppl 1) (1997): 31-36. [PMID: 9068933]
152	Verdy M, Charbonneau L, Verdy I, Belanger R, Bolte E, Chiasson JL "Fenfluramine in the treatment of non-insulin-dependent diabetics: hypoglycemic versus anorectic effect." Int J Obes 7 (1983): 289-97. [PMID: 6629637]
153	Vuksan V, Sievenpiper JL, Koo VY, et al "American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus." Arch Intern Med 160 (2000): 1009-13. [PMID: 10761967]
154	Vuksan V, Stavro MP, Sievenpiper JL, et al "Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes." Diabetes Care 23 (2000): 1221-6. [PMID: 10977009]
155	Whitcroft IA, Thomas JM, Rawsthorne A, et al "Effects of alpha and beta adrenoceptor blocking drugs and ACE inhibitors on long term glucose and lipid control in hypertensive non-insulin dependent diabetics." Horm Metab Res Suppl 22 (1990): 42-6. [PMID: 1975246]
156	Wiederholt IC, Genco M, Foley JM "Recurrent episodes of hypoglycemia induced by propoxyphene." Neurology 17 (1967): 703-6. [PMID: 6067489]
157	Wing LM, Miners JO "Cotrimoxazole as an inhibitor of oxidative drug metabolism: effects of trimethoprim and sulphamethoxazole separately and combined on tolbutamide disposition." Br J Clin Pharmacol 20 (1985): 482-5. [PMID: 3878154]
158	World Health Organization "WHO Public Assessment Reports (WHOPARs).".
159	Wu B, Sato T, Kiyosue T, Arita M "Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs." Cardiovasc Res 26 (1992): 1095-101. [PMID: 1291087]
160	Ben Salem C, Fathallah N, Hmouda H, Bouraoui K "Drug-induced hypoglycaemia: an update." Drug Saf 34 (2011): 21-45. [PMID: 20942513]
161	Product Information. Afrezza (insulin inhalation, rapid acting). MannKind Corporation, Valencia, CA.
162	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
163	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
164	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
165	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
166	Vuorinen-Markkola H, Yki-Jarvinen H "Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus." Metabolism 44 (1995): 85-9. [PMID: 7854171]
167	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
168	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
169	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
170	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
171	Bannwarth B, Pehourcq F, Schaeverbeke T, Dehais J "Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis." Clin Pharmacokinet 30 (1996): 194-210. [PMID: 8882301]
172	Beach BJ, Woods WG, Howell SB "Influence of co-trimoxazole on methotrexate pharmacokinetics in children with acute lymphoblastic leukemia." Am J Pediatr Hematol Oncol 3 (1981): 115-9. [PMID: 6975580]
173	Ferrazzini G, Klein J, Sulh H, Chung D, Griesbrecht E, Koren G "Interaction between trimethoprim-sulfamethoxazole and methotrexate in children with leukemia." J Pediatr 117 (1990): 823-6. [PMID: 2231218]
174	Frain JB "Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole." J Rheumatol 14 (1987): 176-7. [PMID: 3494846]
175	Govert JA, Patton S, Fine RL "Pancytopenia from using trimethoprim and methotrexate." Ann Intern Med 117 (1992): 877-8. [PMID: 1416570]
176	Jeurissen ME, Boerbooms AM, van de Putte LB "Pancytopenia and methotrexate with trimethoprim-sulfamethoxazole." Ann Intern Med 111 (1989): 261. [PMID: 2787612]
177	Liegler DG, Henderson ES, Hahn MA, Oliverio VT "The effect of organic acids on renal clearance of methotrexate in man." Clin Pharmacol Ther 10 (1969): 849-57. [PMID: 5349626]
178	Ng HW, Macfarlane AW, Graham RM, Verbov JL "Near fatal drug interactions with methotrexate given for psoriasis." Br Med J (Clin Res Ed) 295 (1987): 752-3. [PMID: 3119023]
179	Product Information. Bactrim (trimethoprim-sulfamethoxazole). Roche Laboratories, Nutley, NJ.
180	Product Information. Rheumatrex (methotrexate). Lederle Laboratories, Wayne, NJ.
181	Product Information. Sulfadiazine (sulfadiazine). Eon Labs Manufacturing Inc, Laurelton, NY.
182	Thomas DR, Dover JS, Camp RD "Pancytopenia induced by the interaction between methotrexate and trimethoprim-sulfamethoxazole." J Am Acad Dermatol 17 (1987): 1055-6. [PMID: 3501437]
183	Thomas MH, Gutterman LA "Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole." J Rheumatol 13 (1986): 440-1. [PMID: 3487652]
184	Verbov JL "Methotrexate and trimethoprim-sulfamethoxazole." Clin Exp Dermatol 16 (1991): 231. [PMID: 1934583]
185	Multum Information Services, Inc. Expert Review Panel.
186	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
187	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
188	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
189	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
190	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
191	Product Information. Orfadin (nitisinone). Orphan Pharmaceuticals USA, Inc, Nashville, TN.
192	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
193	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
194	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
195	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
196	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
197	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
198	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
199	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
200	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
201	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
202	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
203	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
204	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
205	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
206	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
207	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
208	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
209	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
210	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
211	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
212	Product Information. Antara (fenofibrate). Lupin Pharmaceuticals Inc, Baltimore, MD.
213	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
214	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
215	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
216	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
217	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
218	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
219	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
220	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
221	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
222	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
223	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
224	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
225	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
226	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
227	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
228	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
229	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
230	Gilead Sciences, Inc "About Remdesivir.".
231	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
232	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
233	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
234	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
235	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
236	Miners JO, Rees DLP, Valente L, Veronese ME, Birkett DJ "Human hepatic cytochrome p450 2c9 catalyzes the rate-limiting pathway of torsemide metabolism." J Pharmacol Exp Ther 272 (1995): 1076-81. [PMID: 7891318]
237	Product Information. Demedex (torsemide). Boehringer Mannheim, Gaithersburg, MD.
238	Vormfelde SV, Engelhardt S, Zirk A, et al. "CYP2C9 polymorphisms and the interindividual variability in pharmacokinetics and pharmacodynamics of the loop diuretic drug torsemide." Clin Pharmacol Ther 76 (2004): 557-66. [PMID: 15592327]
239	Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
240	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
241	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
242	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
243	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
244	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
245	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
246	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]
247	Dasgupta A, Dennen DA, Dean R, McLawhon RW "Displacement of phenytoin from serum protein carriers by antibiotics: studies with ceftriaxone, nafcillin, and sulfamethoxazole." Clin Chem 37 (1991): 98-100. [PMID: 1988217]
248	Hansen JM, Kampmann JP, Siersback-Nielsen K, et al. "The effect of different sulfonamides on phenytoin metabolism in man." Acta Med Scand Suppl 624 (1979): 106-10. [PMID: 284708]

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