Drug General Information (ID: DDI0YIOKWN)
Drug Name			Sulfamethoxazole		Drug Info		Lumefantrine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinfective Agents				Antimalarial Agents
Structure

Mechanism of Sulfamethoxazole-Lumefantrine Interaction (Severity Level: Minor)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Sulfamethoxazole				Lumefantrine
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Sulfamethoxazole and Lumefantrine

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]