Details of Drug | MecDDI

Drug General Information (ID: D1470)
Drug Name		Silver sulfadiazine (topical)
Drug Type		Small molecule
Drug Synonymous		Brandiazin; Dermazin; Dermazine; Flamazine; Flammazine; Geben; Sicazine; Silbertone; Silvederma; Silver; Sulfargen; Abbott Brand of Silver Sulfadiazine; Aldo Brand of Silver Sulfadiazine; Major Brand of Silver Sulfadiazine; Medphano Brand of Silver Sulfadiazine; MonarchBrand of Silver Sulfadiazine; Pharmascience Brand of Silver Sulfadiazine; Rhone Poulenc Rorer Brand of Silver Sulfadiazine; SSD AF; SULFADIAZINE SILVER; Sherwood Brand of Silver Sulfadiazine; Silver Sulfafdiazine; Silver sulfadiazinate; Silver sulphadiazine; Solvay Brand of Silver Sulfadiazine; Sulfadiazin silber; Sulfadiazine silver salt; Sulfadiazine silverSilvadene; Zenith Brand of Silver Sulfadiazine; Par Brand 1 of Silver Sulfadiazine; Par Brand 2 of Silver Sulfadiazine; Par Brand 3 of Silver Sulfadiazine; Flamazine (TN); Rhone-Poulenc Rorer Brand of Silver Sulfadiazine; Silvadene (TN); Silver(I) sulfadiazine; Smith & Nephew Brand of Silver Sulfadiazine; Sulfadiazin, silbersalz; Sulfadiazine silver (JP15); Sulfadiazine, Silver [USAN]; Sulfadiazine, silver; Sulfafdiazine, Silver; Thermazene (TN); SSD (1% Silver Sulfadiazine Cream USP); Sulfadiazine, silver (USP); N1-2-Pyrimidinylsulfanilamide monosilver(1+) salt; N(sup 1)-2-Pyrimidinylsulfanilamide monosilver(1+) salt; Silver (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide; Silver 4-amino-N-pyrimidin-2-ylbenzenesulfonamide; Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex; Silver(1+) [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide; Sulfanilamide,N1-2-pyrimidinyl-, monosilver(1+) salt; Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosilver(1+) salt; Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosilver(1+) salt; (4-Amino-N-pyrimidin-2-ylbenzenesulphonamidato-NN,O1)silver; 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide silver salt Click to Show/Hide
Disease Class		1A00-1C4Z: Bacterial infection
Therapeutic Class		Antiinfective Agents
Structure
Structure		3D Structure				2D Structure
Formula		C10H9AgN4O2S
InChI		1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1
InChIKey		UEJSSZHHYBHCEL-UHFFFAOYSA-N
Canonical SMILES		C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Ag+]
External Link
		Pubchem ID		441244
		CAS Number		22199-08-2
		CHEBI ID		9142
		TTD ID		D08JCA

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM071 Increased risk of methemoglobinemia BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Silver sulfadiazine (topical)
Pharmacodynamic additive effects
					Increased risk of methemoglobinemia																																																																Drug Num: 12
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D1337															Prilocaine															C13H20N2O															4906															Major															Inter Info													[1], [2], [3]
D1148															Nitrous acid															HNO2															24529															Major															Inter Info													[4], [5], [6]
D0163															Benzocaine (topical)															C9H11NO2															2337															Moderate															Inter Info													[7], [8], [9]
D0339															Cinchocaine (topical)															C20H29N3O2															3025															Moderate															Inter Info													[7], [8], [9]
D0377															Cocaine (nasal)															C17H21NO4															446220															Moderate															Inter Info													[7], [8], [9]
D0378															Cocaine (topical)															C17H21NO4															446220															Moderate															Inter Info													[7], [8], [9]
D1835															Lidocaine (ophthalmic)															C14H22N2O															3676															Moderate															Inter Info													[7], [8], [9]
D0928															Lidocaine (topical)															C14H22N2O															3676															Moderate															Inter Info													[7], [8], [9]
D1852															Oxybuprocaine (ophthalmic)															C17H28N2O3															4633															Moderate															Inter Info													[7], [8], [9]
D1870															Proparacaine (ophthalmic)															C16H26N2O3															4935															Moderate															Inter Info													[7], [8], [9]
D1904															Tetracaine (ophthalmic)															C15H24N2O2															5411															Moderate															Inter Info													[7], [8], [9]
D1562															Tetracaine (topical)															C15H24N2O2															5411															Moderate															Inter Info													[7], [8], [9]
Pharmacodynamic antagonistic effects
					Attenuated pharmacological effects (Unspecific)																																																																Drug Num: 1
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D1767															Collagenase clostridium histolyticum (topical)															Ca2+4															18680304															Moderate															Inter Info													[10]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
3	Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
4	Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
5	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
6	Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
7	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8	Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
9	Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
10	Product Information. Santyl (collagenase topical). Knoll Pharmaceutical Company, Mount Olive, NJ.