Drug General Information (ID: DDIYGW78SA)
Drug Name			Collagenase clostridium histolyticum (topical)		Drug Info		Silver sulfadiazine (topical)		Drug Info
Drug Type		Protein/peptide				Small molecule
Therapeutic Class		Collagenase				Antiinfective Agents
Structure

Mechanism of Collagenase clostridium histolyticum (topical)-Silver sulfadiazine (topical) Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Collagenase clostridium histolyticum (topical)				Silver sulfadiazine (topical)
Mechanism		Collagenase				Reduce the enzymatic activity of collagenase
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Collagenase clostridium histolyticum (topical) when combined with Silver sulfadiazine (topical)

Recommended Action
Management		Topical preparations containing heavy metals such as silver and mercury should not be used on wounds treated with collagenase. When it is suspected such products have been used, the site should be carefully cleansed by repeated washings with normal saline before application of collagenase.

References
1	Product Information. Santyl (collagenase topical). Knoll Pharmaceutical Company, Mount Olive, NJ.