Details of Drug

Drug General Information (ID: D1393)
Drug Name	Reserpine
Drug Type	Small molecule
Drug Synonymous	Abesta; Abicol; Adelfan; Adelphin; Alkarau; Alkaserp; Alserin; Apoplon; Apsical; Ascoserp; Ascoserpina; Austrapine; Banasil; Banisil; Benazyl; Bioserpine; Brinderdin; Briserine; Broserpine; Cardioserpin; Carditivo; Carpacil; Carrserp; Darebon; Deserpine; Dralserp; Eberpine; Eberspine; Ebserpine; Elfanex; Elserpine; Enipresser; Escaspere; Eserpine; Eskaserp; Eskaserpine; Gammaserpine; Gilucard; Helfoserpin; Hexaplin; Hiposerpil; Hiserpia; Hydropine; Hydroserp; Hypersil; Hypersine; Hypertensan; Idoserp; Idsoserp; Interpina; Kitine; Klimanosid; Lemiserp; Loweserp; Mallopress; Maviserpin; Mayserpine; Mephaserpin; Modenol; Naquival; Nembuserpin; Neoserfin; Neoserp; Neoslowten; Orthoserpina; Perskleran; Pressimedin; Purserpine; Quiescin; Raucap; Raudiford; Raudixin; Raudixoid; Raugal; Raulen; Rauloydin; Raumorine; Raunervil; Raunorine; Raunova; Raupasil; Raupoid; Raurine; Rausan; Rausedan; Rausedil; Rausedyl; Rauserpin; Rauserpine; Rauserpol; Rausingle; Rautrin; Rauvlid; Rauwasedin; Rauwilid; Rauwiloid; Rauwipur; Rauwita; Rauwoleaf; Rawilid; Recipin; Regroton; Resaltex; Resedrex; Resedril; Reserbal; Resercaps; Resercen; Reserfia; Reserjen; Reserlor; Reserp; Reserpal; Reserpamed; Reserpanca; Reserpene; Reserpex; Reserpidefe; Reserpil; Reserpin; Reserpina; Reserpinum; Reserpka; Reserpoid; Reserpur; Reserutin; Resiatric; Residin; Residine; Resine; Resocalm; Resperin; Resperine; Respital; Restran; Rezerpin; Riserpa; Rivased; Rivasin; Rolserp; Roxel; Roxinoid; Roxynoid; Ryser; Salupres; Sandril; Sandron; Sedaraupin; Sedaraupina; Sederaupin; Sedserp; Seominal; Serfin; Serfolia; Serolfia; Serpalan; Serpaloid; Serpaneurona; Serpanray; Serpasil; Serpasol; Serpate; Serpazil; Serpazol; Serpedin; Serpen; Serpena; Serpentil; Serpentin; Serpentina; Serpicon; Serpil; Serpiloid; Serpilum; Serpine; Serpipur; Serpivate; Serpivite; Serpogen; Serpoid; Serpone; Serpyrit; Sertabs; Sertens; Sertensin; Sertina; Supergan; Tefaserpina; Temposerpine; Tensanyl; Tenserpinie; Tensional; Tensionorme; Tepserpine; Terbolan; Transerpin; Triserpin; Tylandril; Unilord; Unipres; VIXO; Esc aspere; Hydromox R; Hypercal B; Loweser p; Neose rfin; Rau sedyl; Renese R; Rese rpamed; Se rpate; V Serp; VI XO; Diupres 250; Diupres 500; ENT 50146; H 520; Hydropres 25; Hydropres 50; Hydrosine 25; R 0875; Apoplon (TN); Diupres-250; Diupres-500; Diurese-R; Diutensen-R; HYDRO-RESERP; Hydrap-ES; Hydromox-R; Key-serpine; L-Carpserp; Neo-serp; Rau-Sed; Renese-R; Rese-lar; Reser-ar; SK-Reserpine; T-Serp; Usaf cb-27; V-Serp; Vio-Serpine; Cam-Ap-Es; L"-Carpserp; R-e-s; Ser-A-Gen; 3P Reserp Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C33H40N2O9
InChI	1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
InChIKey	QEVHRUUCFGRFIF-MDEJGZGSSA-N
Canonical SMILES	COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
External Link
	Pubchem ID	5770
	CAS Number	50-55-5
	CHEBI ID	28487
	TTD ID	D0J4JM
	INTEDE ID	DR2310
	VARIDT ID	DR00636

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM014 Interference of cell/tissue uptake BM034 Additive antidopaminergic effects BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM064 Increased risk of hypoglycemia BM083 Potentiated the pharmacological effects (Unspecific) BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Reserpine
Affected cellular transport
	Transporter inhibition					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[46]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[47], [1], [48]
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[47], [1], [50]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[75]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[47], [88]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[89]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[6]
D1821		Iobenguane (I-123)	C8H10IN3	60860	Moderate		Inter Info	[62], [63], [64]
Pharmacodynamic additive effects
	Additive antidopaminergic effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[4], [5]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[4], [5]
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[90]
	Additive hypertensive effects					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[1], [2], [3]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[1], [2], [3]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[65], [66], [67], [68], [69]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[65], [66], [67], [68], [69]
D1036		Methylene blue	C16H18ClN3S	6099	Moderate		Inter Info	[65], [66], [67], [68], [69]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[65], [66], [67], [68], [69]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[65], [66], [67], [68], [69]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[65], [66], [67], [68], [69]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[65], [66], [67], [68], [69]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[65], [66], [67], [68], [69]
	Additive hypotensive effects					Drug Num: 149
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[7]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[8]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[12], [13], [14]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[15], [16], [17]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[15], [16], [17]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[15], [16], [17]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[12], [13], [14]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[12], [13], [14]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[15], [16], [17]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[21], [22], [23]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[12], [13], [14]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[24], [25], [26]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[12], [13], [14]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[12], [13], [14]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[24], [35], [36]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[37], [38], [39]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[15], [16], [17]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[40], [41], [42]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[43], [44], [25]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[12], [13], [14]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[43], [44], [25]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[37], [38], [39]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[37], [38], [39]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[12], [13], [14]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[12], [13], [14]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[12], [13], [14]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[47], [1], [49]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[12], [13], [14]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[15], [16], [17]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[15], [16], [17]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[15], [16], [17]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[12], [13], [14]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[12], [13], [14]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[43], [44], [25]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[12], [13], [14]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[43], [44], [25]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[12], [13], [14]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[12], [13], [14]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[12], [13], [14]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[12], [13], [14]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[12], [13], [14]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[47], [1], [49]
D0445		Desflurane	C3H2F6O	42113	Moderate		Inter Info	[52], [53]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[12], [13], [14]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[47], [54], [55]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[12], [13], [14]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[12], [13], [14]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[12], [13], [14]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[12], [13], [14]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[12], [13], [14]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[47], [1], [49]
D0570		Enflurane	C3H2ClF5O	3226	Moderate		Inter Info	[52], [53]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[1], [59], [60]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[12], [13], [14]
D0625		Etomidate	C14H16N2O2	667484	Moderate		Inter Info	[52], [53]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[25], [61]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[12], [13], [14]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[12], [13], [14]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[52], [53]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[43], [44], [25]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[12], [13], [14]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[43], [44], [25]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[12], [13], [14]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[12], [13], [14]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[43], [44], [25]
D0855		Isoflurane	C3H2ClF5O	3763	Moderate		Inter Info	[52], [53]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[52], [53]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[15], [16], [17]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[15], [16], [17]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[15], [16], [17]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[1], [73], [74]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[76]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[12], [13], [14]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[12], [13], [14]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[12], [13], [14]
D1024		Methohexital	C14H18N2O3	9034	Moderate		Inter Info	[52], [53]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[52], [53]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[43], [44], [25]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[15], [16], [17]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[12], [13], [14]
D1848		Minoxidil (topical)	C9H15N5O	4201	Moderate		Inter Info	[77], [78]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[12], [13], [14]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[12], [13], [14]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[15], [16], [17]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[15], [16], [17]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[44], [25], [79]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[80], [81], [82]
D1149		Nitrous oxide	N2O	948	Moderate		Inter Info	[52], [53]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[12], [13], [14]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[12], [13], [14]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[12], [13], [14]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[12], [13], [14]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[15], [16], [17]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[86]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[15], [16], [17]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[43], [44], [25]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[52], [53]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[15], [16], [17]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[12], [13], [14]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[12], [13], [14]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[12], [13], [14]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[87]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[1], [59], [60]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[12], [13], [14]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[15], [16], [17]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[12], [13], [14]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[52], [53]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[15], [16], [17]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[15], [16], [17]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[1], [59], [60]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[12], [13], [14]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[43], [44], [25]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[12], [13], [14]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[40], [41], [42]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[91], [92], [93]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[12], [13], [14]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[27], [28], [29], [30], [21], [31], [22], [32], [23], [33], [34]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[12], [13], [14]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[40], [41], [42]
D0711		Garlic	NA	NA	Minor		Inter Info	[95], [96]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[97], [98]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[51]
	Increased risk of hypoglycemia					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[18], [19], [20]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[18], [19], [20]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[18], [19], [20]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[18], [19], [20]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[18], [19], [20]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[18], [19], [20]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[18], [19], [20]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[18], [19], [20]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[18], [19], [20]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[18], [19], [20]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[18], [19], [20]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[18], [19], [20]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[18], [19], [20]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[18], [19], [20]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[18], [19], [20]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[18], [19], [20]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[18], [19], [20]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[18], [19], [20]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[18], [19], [20]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[18], [19], [20]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[18], [19], [20]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[18], [19], [20]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[56], [57], [58]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[56], [57], [58]
D0582		Epinephrine (ophthalmic)	C9H13NO3	5816	Moderate		Inter Info	[56], [57], [58]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[56], [57], [58]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[56], [57], [58]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[56], [57], [58]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[56], [57], [58]
D1107		Naphazoline (nasal)	C14H14N2	4436	Moderate		Inter Info	[56], [57], [58]
D1108		Naphazoline (ophthalmic)	C14H14N2	4436	Moderate		Inter Info	[56], [57], [58]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[56], [57], [58]
D1200		Oxitriptan	C11H12N2O3	439280	Moderate		Inter Info	[83], [84], [85]
D1204		Oxymetazoline (nasal)	C16H24N2O	4636	Moderate		Inter Info	[56], [57], [58]
D1205		Oxymetazoline (ophthalmic)	C16H24N2O	4636	Moderate		Inter Info	[56], [57], [58]
D1206		Oxymetazoline (topical)	C16H24N2O	4636	Moderate		Inter Info	[56], [57], [58]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[56], [57], [58]
D1567		Tetryzoline (nasal)	C13H16N2	5419	Moderate		Inter Info	[56], [57], [58]
D1568		Tetryzoline (ophthalmic)	C13H16N2	5419	Moderate		Inter Info	[56], [57], [58]
D1712		Xylometazoline (nasal)	C16H24N2	5709	Moderate		Inter Info	[56], [57], [58]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[9], [10], [11]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[1], [45]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[1], [45]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[1], [45]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[1], [45]
D0460		Dexmethylphenidate	C14H19NO2	154101	Moderate		Inter Info	[9], [10], [11]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[9], [10], [11]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[9], [10], [11]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[9], [52], [58]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[9], [52], [58]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[9], [52], [58]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[1], [45]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[1], [45]
D0857		Isometheptene	C9H19N	22297	Moderate		Inter Info	[9], [52], [58]
D0913		Levmetamfetamine (nasal)	C10H15N	36604	Moderate		Inter Info	[9], [52], [58]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[70], [71], [72]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[9], [10], [11]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[9], [10], [11]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[9], [52], [58]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[9], [10], [11]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[9], [52], [58]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[9], [10], [11]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[1], [45]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[9], [10], [11]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[9], [52], [58]
D1277		Phenylephrine (nasal)	C9H13NO2	6041	Moderate		Inter Info	[9], [52], [58]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[9], [52], [58]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[9], [52], [58]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[1], [45]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[1], [45]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[9], [52], [58]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[1], [45]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[1], [45]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[94], [25]

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97	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
98	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.

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Details of Drug

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