Details of Drug

Drug General Information (ID: D1363)
Drug Name	Pseudoephedrine
Drug Type	Small molecule
Drug Synonymous	Balminil Decongestant Syrup; Dimetapp Decongestant; Dimetapp Decongestant Pediatric Drops; Drixoral Nasal Decongestant; Pseudoephedrine Ephedrine; Sudafed Decongestant Extra Strength; Triaminic AM Decongestant Formula; Triaminic Infant Oral Decongestant Drops; Efidac 24 PseudoephedrineHcl; Sudafed Decongestant 12 Hour; Pseudoefedrina [INN-Spanish]; Pseudoephedrine (INN); Pseudoephedrine [INN:BAN]; Pseudoephedrine d-form; Pseudoephedrinum [INN-Latin]; Sudafed (TN); Alpha-(1-(Methylamino)ethyl)benzyl alcohol; D-psi-2-Methylamino-1-phenyl-1-propanol; Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alpha-S)-(9CI); (+)-(1S,2S)-Pseudoephedrine; (1S,2S)-(+)-Pseudoephedrine; (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol; (1S,2S)-2-Methylamino-1-phenyl-1-propanol; (1S,2S)-Pseudoephedrine; (1S,2S)-Pseudoephedrine, polymer-bound Click to Show/Hide
Disease Class	MD11: Breathing abnormality
Therapeutic Class	Decongestants
Structure
Structure	3D Structure		2D Structure
Formula	C10H15NO
InChI	1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
InChIKey	KWGRBVOPPLSCSI-WCBMZHEXSA-N
Canonical SMILES	CC(C(C1=CC=CC=C1)O)NC
External Link
	Pubchem ID	7028
	CAS Number	90-82-4
	CHEBI ID	51209
	TTD ID	D00HHS
	INTEDE ID	DR1369

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM018 Non-CYP450 enzyme inhibition BM029 Altered urine pH BM040 Additive dopaminergic effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM061 Increased risk of hyperpyrexia BM078 Increased risk of rapid heart rate BM081 Increased risk of ventricular arrhythmias BM083 Potentiated the pharmacological effects (Unspecific) BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Pseudoephedrine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[30]
D1821		Iobenguane (I-123)	C8H10IN3	60860	Moderate		Inter Info	[94], [95], [96]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[104], [9], [31], [32], [33], [105], [12], [14], [15], [106], [16], [17], [24], [107], [26], [60], [103], [108], [29]
Affected excretion pathways
	Altered urine pH					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0886		Lactic acid	C3H6O3	612	Moderate		Inter Info	[98], [99], [100]
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[98], [99], [100]
D1478		Sodium acetate	C2H3NaO2	517045	Moderate		Inter Info	[98], [99], [100]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[98], [99], [100]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[98], [99], [100]
D1654		Tromethamine	C4H11NO3	6503	Moderate		Inter Info	[98], [99], [100]
D0111		Ascorbic acid	C6H8O6	54670067	Minor		Inter Info	[98], [99], [100]
D1022		Methionine	C5H11NO2S	6137	Minor		Inter Info	[98], [99], [100]
D0070		Ammonium chloride	ClH4N	25517	Minor		Inter Info	[98], [99], [100]
D1086		Monopotassium phosphate	H2KO4P	516951	Minor		Inter Info	[98], [99], [100]
D1486		Sodium phosphate, monobasic	NA	NA	Minor		Inter Info	[98], [99], [100]
Pharmacodynamic additive effects
	Additive dopaminergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[89]
	Additive hypertensive effects					Drug Num: 47
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[1], [2], [3], [4]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[1], [2], [3], [5], [4], [6]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[1], [4], [6]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[1], [4], [6]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[1], [4], [6]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[48], [55], [68]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[48], [55], [68]
D0523		Doxapram	C24H30N2O2	3156	Moderate		Inter Info	[48], [55], [68]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[81], [82], [83]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[48], [55], [68]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[48], [55], [68]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[33], [6]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[81], [82], [83]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[33], [87], [88]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[48], [55], [68]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[48], [55], [68]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[81], [82], [83]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[48], [55], [68]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
D0460		Dexmethylphenidate	C14H19NO2	154101	Moderate		Inter Info	[48], [55], [68]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[48], [55], [68]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[48], [55], [68]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[90]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[81], [82], [83]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[81], [82], [83]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[81], [82], [83]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[32], [33], [97]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[81], [82], [83]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[48], [55], [68]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[48], [55], [68]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[81], [82], [83]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[48], [55], [68]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[81], [82], [83]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[81], [82], [83]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[9], [10], [31], [33], [11], [35], [12], [13], [15], [16], [17], [18], [19], [20], [38], [22], [40], [23], [102], [57], [25], [27], [103], [28], [29]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[81], [82], [83]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[81], [82], [83]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[81], [82], [83]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[109]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[110]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[81], [82], [83]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[81], [82], [83]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[72], [73], [74], [75], [76], [77]
	Additive hypotensive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[91], [92], [93]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[91], [92], [93]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[91], [92], [93]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[91], [92], [93]
	Increased risk of hyperpyrexia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[7], [8]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[9], [10], [31], [32], [33], [34], [11], [35], [12], [13], [14], [15], [16], [17], [18], [19], [20], [36], [37], [21], [38], [39], [22], [40], [23], [41], [42], [43], [24], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [25], [26], [59], [60], [27], [28], [61], [62], [63], [29]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
	Increased risk of ventricular arrhythmias					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[69], [70], [71]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[69], [70], [71]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[84], [85], [86]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[84], [85], [86]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[32], [33], [101]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[84], [85], [86]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[64], [65], [66]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[64], [65], [66]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[64], [65], [66]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[64], [65], [66]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[64], [65], [66]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[64], [65], [66]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[64], [65], [66]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[64], [65], [66]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[64], [65], [66]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[64], [65], [66]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[64], [65], [66]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[64], [65], [66]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[64], [65], [66]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[64], [65], [66]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[64], [65], [66]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[64], [65], [66]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[64], [65], [66]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[64], [65], [66]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[64], [65], [66]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[64], [65], [66]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[64], [65], [66]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[64], [65], [66]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[64], [65], [66]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[64], [65], [66]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[64], [65], [66]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[64], [65], [66]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[64], [65], [66]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[64], [65], [66]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[64], [65], [66]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[64], [65], [66]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[64], [65], [66]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[64], [65], [66]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[64], [65], [66]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[64], [65], [66]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[64], [65], [66]
	Antagonize the effect of antihypertensive agents					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[32], [33], [67]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[32], [33], [67]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[32], [33], [67]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[32], [33], [67]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[32], [33], [67]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[32], [33], [67]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[78], [79], [80]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[32], [33], [67]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[32], [33], [67]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[32], [33], [67]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[32], [33], [67]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[32], [33], [67]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[32], [33], [67]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[78], [79], [80]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[64], [65], [66]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[64], [65], [66]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[64], [65], [66]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[78], [79], [80]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[32], [33], [67]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[32], [33], [67]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[32], [33], [67]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[64], [65], [66]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[32], [33], [67]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[32], [33], [67]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[78], [79], [80]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[32], [33], [67]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[32], [33], [67]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[32], [33], [67]

References
1	Barthel W, Glusa E, Koth W "Interactions of dihydroergotamine with etilefrine in human leg veins in vitro and in situ." Int J Clin Pharmacol Ther Toxicol 25 (1987): 63-9. [PMID: 2881898]
2	Buchanan N, Cane RD, Miller M "Symmetrical gangrene of the extremities associated with the use of dopamine subsequent to ergometrine administration." Intensive Care Med 3 (1977): 55-6. [PMID: 561121]
3	Chuang SS "Finger ischemia secondary to the synergistic agonist effect of norepinephrine and ergonovine and in a burn patient." Burns 29 (2003): 92-4. [PMID: 12543053]
4	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
5	Product Information. Bellergal-S (ergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
6	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
7	Hendershot PE, Antal EJ, Welshman IR, Batts DH, Hopkins NK "Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr." J Clin Pharmacol 41 (2001): 563-72. [PMID: 11361053]
8	Product Information. Zyvox (linezolid) Pharmacia and Upjohn, Kalamazoo, MI.
9	Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
10	Boakes AJ, Laurence DR, Teoh PC, Barar FS, Benedikter LT, Prichard BN "Interactions between sympathomimetic amines and antidepressant agents in man." Br Med J 1 (1973): 311-5. [PMID: 4685619]
11	Cuthbert MF, Greenberg MP, Morley SW "Cough and cold remedies: a potential danger to patients on monoamine oxidase inhibitors." Br Med J 1 (1969): 404-6. [PMID: 5763957]
12	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
13	Davies B, Bannister R, Sever P "Pressor amines and monoamine-oxidase inhibitors for treatment of postural hypotension in autonomic failure: limitations and hazards." Lancet 1 (1978): 172-5. [PMID: 74603]
14	De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5. [PMID: 4379192]
15	Elis J, Laurence DR, Mattie H, Prichard BN "Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure." Br Med J 2 (1967): 75-8. [PMID: 6020852]
16	Goldberg LI "Monoamine oxidase inhibitors: adverse reactions and possible mechanisms." JAMA 190 (1964): 456-62. [PMID: 14197995]
17	Goulet JP, Perusse R, Turcotte JY "Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions." Oral Surg Oral Med Oral Pathol 74 (1992): 692-7. [PMID: 1359489]
18	Harrison WM, McGrath PJ, Stewart JW, Quitkin F "MAOIs and hypertensive crises: the role of OTC drugs." J Clin Psychiatry 50 (1989): 64-5. [PMID: 2464583]
19	Horler AR, Wynne NA "Hypertensive crisis due to pargyline and metaraminol." Br Med J 5459 (1965): 460-1. [PMID: 14314914]
20	Humberstone PM "Hypertension from cold remedies." Br Med J 1 (1969): 846. [PMID: 5813090]
21	Kraft KE, Dore FH "Computerized drug interaction programs: how reliable?." JAMA 275 (1996): 1087. [PMID: 8601924]
22	Lefebvre H, Noblet C, Morre N, Wolf LM "Pseudo-phaeochromocytoma after multiple drug interactions involving the selective monoamine oxidase inhibitor selegiline." Clin Endocrinol (Oxf) 42 (1995): 95-8. [PMID: 7889639]
23	Mason AM, Buckle RM ""Cold" cures and monoamine-oxidase inhibitors." Br Med J 1 (1969): 845-6. [PMID: 5813089]
24	Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7. [PMID: 5655478]
25	Schildkraut JJ, Klerman GL, Friend DG, Greenblatt M "Biochemical and pressor effects of oral d,l-dihydroxyphenylalanine in patients pretreated with antidepressant drugs." Ann N Y Acad Sci 107 (1963): 1005-15. [PMID: 13991689]
26	Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
27	Sjoqvist F "Psychotropic drugs (2) interaction between monoamine oxidase (MAO) inhibitors and other substances." Proc R Soc Med 58 (1965): 967-78. [PMID: 4952963]
28	Smookler S, Bermudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the-counter appetite suppressant." Ann Intern Med 11 (1982): 482-4. [PMID: 7114595]
29	Wright SP "Hazards with monoamine-oxidase inhibitors: a persistent problem." Lancet 1 (1978): 284-5. [PMID: 74715]
30	Product Information. Azedra (iobenguane I-131). Progenics Pharmaceuticals, Inc., New York, NY.
31	Boakes AJ, Laurence DR, Teoh PC, Barar FS, Benedikter LT, Pritchard BN "Interactions between sympathomimetic amines and antidepressant agents in man." Br Med J 1 (1973): 311-5. [PMID: 4685619]
32	Cerner Multum, Inc. "Australian Product Information.".
33	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
34	Coleman AL, Robin AL, Pollack IP, Rudikoff MT, Enger C, Mayer PR "Cardiovascular and intraocular pressure effects and plasma concentrations of apraclonidine." Arch Ophthalmol 108 (1990): 1264-7. [PMID: 2205182]
35	FISCHER E, ORLANDO J, LUDMER RL. INFLUENCIA DE METILANFETAMINA, IPRONIACIDA Y TRANILCIPROMINA SOBRE LA DEPRESI'ON PSICOMOTORA ADRENAL'INICA [EFFECT OF METHYLAMPHETAMINE, IPRONIAZID AND TRANYLCYPROMINE ON ADRENALINE PSYCHOMOTOR DEPRESSION]. Prensa Med Argent. 1964;51:1538-1540. [PMID: 14272082]
36	Hunter KR, Boakes AJ, Laurence DR, Stern GM "Monoamine oxidase inhibitors and L-dopa." Br Med J 3 (1970): 388. [PMID: 5451592]
37	King MH, Richards DW "Near syncope and chest tightness after administration of apraclonidine before argon laser iridotomy." Am J Ophthalmol 110 (1990): 308-9. [PMID: 2204271]
38	Krisko I, Lewis E, Johnson JE "Severe hyperpyrexia due to tranylcypromine-amphetamine toxicity." Ann Intern Med 70 (1969): 559-64. [PMID: 5775035]
39	Kronig MH, Roose SP, Walsh BT, Woodring S, Glassman AH "Blood pressure effects of phenelzine." J Clin Psychopharmacol 3 (1983): 307-10. [PMID: 6630590]
40	Markowitz JS, Patrick KS "Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder." Clin Pharmacokinet 40 (2001): 753-72. [PMID: 11707061]
41	Nordlund JR, Pasquale LR, Robin AL, Rudikoff MT, Ordman J, Chen KS, Walt J "The cardiovascular, pulmonary, and ocular hypotensive effects of 0.2% brimonidine." Arch Ophthalmol 113 (1995): 77-83. [PMID: 7826297]
42	Paykel ES "Hallucinosis on combined methyldopa and pargyline." Br Med J 1 (1966): 803. [PMID: 5910115]
43	Pekdemir M, Yanturali S, Karakus G "More than just an ocular solution." Emerg Med J 22 (2005): 753-4. [PMID: 16189050]
44	Product Information. Adderall (amphetamine-dextroamphetamine) Shire Richwood Pharmaceutical Company, Florence, KY.
45	Product Information. Aldomet (methyldopa). Merck & Co, Inc, West Point, PA.
46	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
47	Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
48	Product Information. Focalin (dexmethylphenidate). Mikart Inc, Atlanta, GA.
49	Product Information. Iopidine (apraclonidine). Alcon Laboratories Inc, Fort Worth, TX.
50	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
51	Product Information. Parcopa (carbidopa-levodopa). Schwarz Pharma, Mequon, WI.
52	Product Information. Ritalin (methylphenidate). Novartis Pharmaceuticals, East Hanover, NJ.
53	Product Information. Sinemet (carbidopa-levodopa). DuPont Pharmaceuticals, Wilmington, DE.
54	Product Information. Stalevo 50 (carbidopa/entacapone/levodopa). Novartis Pharmaceuticals, East Hanover, NJ.
55	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
56	Product Information. Tyzine (tetrahydrozoline). Kenwood Laboratories, Fairfield, NJ.
57	Product Information. Vyvanse (lisdexamfetamine). Shire US Inc, Florence, KY.
58	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
59	Sharpe J, Marquez-Julio A, Ashby P "Idiopathic orthostatic hypotension treated with levodopa and MAO inhibitor: a preliminary report." Can Med Assoc J 107 (1972): 296-300. [PMID: 5056115]
60	Sjoerdsma A "Catecholamine-drug interactions in man." Pharmacol Rev 18 (1966): 673-83. [PMID: 5904180]
61	Teychenne PF, Calne DB, Lewis PJ, Findley LJ "Interactions of levodopa with inhibitors of monoamine oxidase and L-aromatic amino acid decarboxylase." Clin Pharmacol Ther 18 (1975): 273-7. [PMID: 1164817]
62	van Rossum JM "Potential danger of monoamineoxidase inhibitors and a-methyldopa." Lancet 1 (1963): 950-1. [PMID: 13975251]
63	van Rossum JM, Hurkmans JA "Reversal of the effect of a-Methyldopa by monamine oxidase inhibitors." J Pharm Pharmacol 15 (1963): 493-9. [PMID: 14059015]
64	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
65	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
66	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
67	Product Information. Allegra-D (fexofenadine-pseudoephedrine). Chattem Consumer Products, Chattanooga, TN.
68	Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
69	Product Information. Lanoxin (digoxin). Glaxo Wellcome, Research Triangle Park, NC.
70	Product Information. Claritin-D (loratadine-pseudoephedrine). Schering-Plough, Liberty Corner, NJ.
71	Product Information. Epinephrine Hydrochloride Injection (epinephrine). Abbott Pharmaceutical, Abbott Park, IL.
72	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
73	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
74	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
75	Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
76	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
77	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
78	Gulati OD, Dave BT, Gokhale SD, Shah KM "Antagonism of adrenergic neuron blockade in hypertensive subjects." Clin Pharmacol Ther 7 (1966): 510-4. [PMID: 5939974]
79	Ziegler CH, Lovette JB "Operative complications after therapy with reserpine and reserpine compounds." JAMA 176 (1961): 114-7
80	Spiers AS, Calne DB "Action of dopamine on the human iris." Br Med J 4 (1969): 333-5
81	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
82	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
83	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
84	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
85	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
86	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
87	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
88	Product Information. Syntocinon (oxytocin). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
89	Reeves RR, Pinkofsky HB "Postpartum psychosis induced by bromocriptine and pseudoephedrine." J Fam Pract 45 (1997): 164-6. [PMID: 9267376]
90	Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
91	Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
92	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
93	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
94	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
95	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
96	Product Information. AdreView (iobenguane I-123). GE Healthcare, Princeton, NJ.
97	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
98	Brater DC, Kaojarern S, Benet LZ, et al "Renal excretion of pseudoephedrine." Clin Pharmacol Ther 28 (1980): 690-4. [PMID: 7438686]
99	Kuntzman RG, Tsai I, Brand L, Mark LC "The influence of urinary pH on the plasma half-life of pseudoephedrine in man and dog and a sensitive assay for its determination in human plasma." Clin Pharmacol Ther 12 (1971): 62-7. [PMID: 5541135]
100	Wilkinson GR, Beckett AH "Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47. [PMID: 5656593]
101	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
102	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
103	Smookler S, Barmudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the counter appetite suppressant." Ann Emerg Med 11 (1982): 482-4. [PMID: 7114595]
104	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
105	Cusson JR, Goldenberg E, Larochelle P "Effect of a novel monoamine-oxidase inhibitor, moclobemide on the sensitivity to intravenous tyramine and norepinephrine in humans." J Clin Pharmacol 31 (1991): 462-7. [PMID: 2050833]
106	Fenwick MJ, Muwanga CL "Anaphylaxis and monoamine oxidase inhibitors--the use of adrenaline." J Accid Emerg Med 17 (2000): 143-4. [PMID: 10718244]
107	Product Information. Xadago (safinamide). US WorldMeds LLC, Louisville , KY.
108	Thompson DS, Sweet RA, Marzula K, Peredes JC "Lack of interaction of monoamine oxidase inhibitors and epinephrine in an older patient." J Clin Psychopharmacol 17 (1997): 322-3. [PMID: 9241014]
109	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
110	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence