Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIWCQOHZT)
  Drug Name Pseudoephedrine Drug Info Bromocriptine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Decongestants Antiparkinson Agents
  Structure

 Mechanism of Pseudoephedrine-Bromocriptine Interaction (Severity Level: Moderate)
     Additive dopaminergic effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Pseudoephedrine Bromocriptine
      Mechanism Dopaminergic effects
Dopamine transporter  Inhibitor 		Dopaminergic effects
Dopamine receptor  Agonist
      Key Mechanism Factor 1
Factor Name Dopamine transporter
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Structure Sequence
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
Gene Name SLC6A3
Uniprot ID SC6A3_HUMAN
KEGG Pathway hsa:6531
Protein Family Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
Protein Function
Amine transporter (PubMed:1406597, PubMed:8302271, PubMed:15505207). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
    Click to Show/Hide
      Key Mechanism Factor 2
Factor Name Dopamine receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
    Click to Show/Hide
      Mechanism Description
  • Additive dopaminergic effects by the combination of Pseudoephedrine and Bromocriptine 

Recommended Action
      Management If these two drugs must be taken concurrently, the patient's cardiovascular and mental status should be closely monitored.

References
1 Reeves RR, Pinkofsky HB "Postpartum psychosis induced by bromocriptine and pseudoephedrine." J Fam Pract 45 (1997): 164-6. [PMID: 9267376]