Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIE0Q9LJA)
  Drug Name Alfuzosin Drug Info Pseudoephedrine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Decongestants
  Structure

 Mechanism of Alfuzosin-Pseudoephedrine Interaction (Severity Level: Moderate)
     Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Alfuzosin Pseudoephedrine
      Mechanism Hypotensive effects
Alpha-1 adrenergic receptor  Antagonist 		Hypertensive effects
Alpha-1 adrenergic receptor  Agonist
      Key Mechanism Factor 1
Factor Name Adrenergic receptor alpha-1 Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Alfuzosin when combined with Pseudoephedrine 

Recommended Action
      Management Caution and close monitoring of blood pressure is recommended if pseudoephedrine is administered with these antihypertensives. Discontinuation of the sympathomimetic may be necessary if hypertension develops.

References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Allegra-D (fexofenadine-pseudoephedrine). Chattem Consumer Products, Chattanooga, TN.