Details of Drug

Drug General Information (ID: D1294)
Drug Name	Pioglitazone
Drug Type	Small molecule
Drug Synonymous	111025-46-8; Actos; Pioglitazona; Pioglitazonum; Glustin; Zactos; 105355-27-9; Pioglitazonum [INN-Latin]; Pioglitazona [INN-Spanish]; Duetact; Pioglitazone [INN:BAN]; Pioglitazone [BAN:INN]; 5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione; AD-4833; U 72107; CHEBI:8228; Pioglitazone (Actos); HSDB 7322; Actos (TN); 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione; C19H20N2O3S; AD 4833; 5-[4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]BENZYL]-2,4-THIAZOLIDINEDIONE; U 72107A; Actos; Actost; Glustin (TN); HS-0047; Pioglitazone (INN); U-72107; U72,107A; Zactos (TN); (+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione; (+/-)-5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione; (+/-)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione; 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-(9CI); 5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione; 5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione; 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione; 5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine-2,4-dione; Linagliptin + pioglitazone; PCG1 Click to Show/Hide
Disease Class	5A2Y: Acute diabete complication; 5B80-5B81: Obesity; 5A11: Type 2 diabetes mellitus
Therapeutic Class	Antidiabetic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C19H20N2O3S
InChI	1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)
InChIKey	HYAFETHFCAUJAY-UHFFFAOYSA-N
Canonical SMILES	CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
External Link
	Pubchem ID	4829
	CAS Number	111025-46-8
	CHEBI ID	8228
	TTD ID	D03OFF
	VARIDT ID	DR00518

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM024 Competitive inhibition of metabolic enzyme BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Pioglitazone
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[2]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1], [2], [3], [4]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[11], [12], [13], [14], [15], [2], [16], [17]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[25], [26]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[2]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[2]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[2]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[42], [43]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[44]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[2]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[2]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[50]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[52]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[65]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[11], [12], [13], [14], [66], [2], [16], [17], [67]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[80]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[11], [12], [13], [14], [66], [2], [16], [17], [67]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[81]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[25], [26]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[83]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[30], [88], [25], [26]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[11], [12], [13], [14], [66], [2], [16], [17], [67]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[40], [30], [89]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[90], [91], [92]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[11], [12], [13], [14], [66], [2], [16], [17], [67]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[2]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[95]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[11], [12], [13], [14], [66], [2], [16], [17], [67]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[2]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[11], [12], [13], [14], [66], [2], [16], [17], [67]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[102]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[11], [12], [13], [14], [66], [2], [16], [17], [67]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[11], [12], [13], [14], [66], [2], [16], [17], [67]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[11], [12], [13], [14], [66], [2], [16], [17], [67]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[40], [30], [111]
	CYP450 enzyme induction					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[19]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[33]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[2]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[8], [40], [30]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[56], [57], [58]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[30], [72], [73]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[40], [30], [79]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[2]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[82]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[22], [2], [23]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[93], [30], [94]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[96], [66], [2], [16], [17]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[40], [30], [100]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[96], [66], [2], [16], [17]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[30], [101]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[96], [66], [2], [16], [17]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[2]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[96], [66], [2], [16], [17]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[96], [16], [17]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[2]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[2]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[2]
D0061		Aminoglutethimide	C13H16N2O2	2145	Minor		Inter Info	[115], [116]
D0619		Ethinylestradiol	C20H24O2	5991	Minor		Inter Info	[117], [118], [119]
D0626		Etonogestrel	C22H28O2	6917715	Minor		Inter Info	[120], [117], [118], [2], [119]
D0922		Levonorgestrel	C21H28O2	13109	Minor		Inter Info	[120], [117], [118], [2], [119]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Minor		Inter Info	[117], [118], [119]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[123], [124], [125], [126], [127]
D1154		Norethisterone	C20H26O2	6230	Minor		Inter Info	[117], [118], [119]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[123], [124], [125], [126], [127]
D0536		Drospirenone	C24H30O3	68873	Minor		Inter Info	[120], [117], [118], [2], [119]
D1011		Mestranol	C21H26O2	6291	Minor		Inter Info	[117], [118], [119]
D1157		Norgestrel	C21H28O2	13109	Minor		Inter Info	[120], [117], [118], [2], [119]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1377		Raltegravir	C20H21FN6O5	54671008	Minor		Inter Info	[8], [40], [30], [131]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[107], [108]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[107], [108]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[8], [9], [10]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[18]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[20]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[21]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[8], [9], [10]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[37]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[38], [39]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[40], [30], [41]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[45], [46], [47], [48]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[45], [46], [47], [48]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[30], [49]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[51]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[71]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[74]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[30], [75]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[87]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[45], [46], [47], [48]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[40], [30], [97], [98], [99]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[30], [103]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[109], [110]
	Increased risk of hypoglycemia					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[27], [28], [29]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[30], [31], [32]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[34], [35], [36]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[34], [35], [36]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[27], [28], [29]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[34], [35], [36]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[27], [28], [29]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[34], [35], [36]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[34], [35], [36]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[27], [28], [29]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[34], [35], [36]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[34], [35], [36]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[34], [35], [36]
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[27], [28], [29]
D1862		Pegvisomant	NA	NA	Moderate		Inter Info	[59], [60], [61]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[27], [28], [29]
D1736		Aloe Vera Leaf	C15H10O5	10207	Moderate		Inter Info	[68], [69], [70]
D1759		Chromic chloride	NA	NA	Moderate		Inter Info	[76], [77], [78]
D0332		Chromium picolinate	C18H12CrN3O6	151932	Moderate		Inter Info	[76], [77], [78]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[34], [35], [36]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[27], [28], [29]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[34], [35], [36]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[84], [85], [86]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[34], [35], [36]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[27], [28], [29]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[27], [28], [29]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[34], [35], [36]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[27], [28], [29]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[34], [35], [36]
D1661		Turmeric	C21H20O6	969516	Moderate		Inter Info	[104], [105], [106]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[27], [28], [29]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[34], [35], [36]
D1836		Lipoic acid	C8H14O2S2	6112	Minor		Inter Info	[60], [121], [122]
D0711		Garlic	NA	NA	Minor		Inter Info	[128], [129], [130]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 137
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[5], [6], [7]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[22], [23], [24]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[22], [23], [24]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[22], [23], [24]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[22], [23], [24]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[22], [23], [24]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[22], [23], [24]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[22], [23], [24]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[22], [23], [24]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[22], [23], [24]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[22], [23], [24]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[22], [23], [24]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[22], [23], [24]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[22], [23], [24]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[22], [23], [24]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[22], [23], [24]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[22], [23], [24]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[22], [23], [24]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[22], [23], [24]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[22], [23], [24]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[22], [23], [24]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[22], [23], [24]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[22], [23], [24]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[22], [23], [24]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[22], [23], [24]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[22], [23], [24]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[22], [23], [24]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[22], [23], [24]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[22], [23], [24]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[22], [23], [24]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[22], [23], [24]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[22], [23], [24]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[22], [23], [24]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[22], [23], [24]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[22], [23], [24]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[22], [23], [24]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[22], [23], [24]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[22], [23], [24]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[22], [23], [24]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[22], [23], [24]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[22], [23], [24]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[22], [23], [24]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[22], [23], [24]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[22], [23], [24]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[22], [23], [24]
D1129		Niacin	C6H5NO2	938	Moderate		Inter Info	[22], [23], [24]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[22], [23], [24]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[53], [54], [55]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[22], [23], [24]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[22], [23], [24]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[22], [23], [24]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[62], [63], [64]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[22], [23], [24]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[22], [23], [24]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[22], [23], [24]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[22], [23], [24]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[22], [23], [24]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[22], [23], [24]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[22], [23], [24]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[22], [23], [24]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[22], [23], [24]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[22], [23], [24]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[22], [23], [24]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[22], [23], [24]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[22], [23], [24]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[22], [23], [24]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[22], [23], [24]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[22], [23], [24]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[22], [23], [24]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[22], [23], [24]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[22], [23], [24]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[22], [23], [24]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[22], [23], [24]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[22], [23], [24]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[22], [23], [24]
D0608		Estramustine	C23H31Cl2NO3	259331	Moderate		Inter Info	[22], [23], [24]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[22], [23], [24]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[22], [23], [24]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[22], [23], [24]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[22], [23], [24]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[22], [23], [24]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[22], [23], [24]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[22], [23], [24]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[53], [54], [55]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[22], [23], [24]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[22], [23], [24]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[22], [23], [24]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[22], [23], [24]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[22], [23], [24]
D1132		Nicotinamide	C6H6N2O	936	Moderate		Inter Info	[22], [23], [24]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[22], [23], [24]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[22], [23], [24]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[53], [54], [55]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[22], [23], [24]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[22], [23], [24]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[22], [23], [24]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[22], [23], [24]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[22], [23], [24]
D1531		Tagraxofusp	NA	NA	Moderate		Inter Info	[22], [23], [24]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[22], [23], [24]
D1900		Teprotumumab	NA	NA	Moderate		Inter Info	[22], [23], [24]
D1902		Tesamorelin	C221H366N72O67S	16137828	Moderate		Inter Info	[22], [23], [24]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[22], [23], [24]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[22], [23], [24]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[22], [23], [24]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[22], [23], [24]
D1707		Vorinostat	C14H20N2O3	5311	Moderate		Inter Info	[22], [23], [24]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[22], [23], [24]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[22], [23], [24]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[22], [23], [24]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[22], [23], [24]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[22], [23], [24]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[22], [23], [24]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[22], [23], [24]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[22], [23], [24]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[22], [23], [24]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[22], [23], [24]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[22], [23], [24]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[22], [23], [24]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[22], [23], [24]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[22], [23], [24]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[22], [23], [24]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[22], [23], [24]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[22], [23], [24]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[22], [23], [24]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[22], [23], [24]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[22], [23], [24]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[22], [23], [24]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[22], [23], [24]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[22], [23], [24]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[22], [23], [24]
D1762		Clobetasol (topical)	C22H28ClFO4	5311051	Minor		Inter Info	[112], [113], [114]
D1770		Desonide (topical)	C24H32O6	5311066	Minor		Inter Info	[112], [113], [114]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Minor		Inter Info	[30], [59], [60]
D1772		Dexamethasone (topical)	C22H29FO5	5743	Minor		Inter Info	[112], [113], [114]
D0685		Fluticasone (topical)	C22H27F3O4S	5311101	Minor		Inter Info	[112], [113], [114]
D1804		Halcinonide (topical)	C24H32ClFO5	443943	Minor		Inter Info	[112], [113], [114]
	Antagonize the effect of antihypertensive agents					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1888		Sermorelin	C149H246N44O42S	16132413	Moderate		Inter Info	[22], [23], [24]
D1908		Thyrotropin alfa	C16H22N6O4	32281	Moderate		Inter Info	[22], [23], [24]
D1735		Alclometasone (topical)	C22H29ClO5	5311000	Minor		Inter Info	[112], [113], [114]
D1737		Amcinonide	C28H35FO7	443958	Minor		Inter Info	[112], [113], [114]
D1748		Betamethasone (topical)	C22H29FO5	9782	Minor		Inter Info	[112], [113], [114]
D1763		Clocortolone (topical)	C22H28ClFO4	5311052	Minor		Inter Info	[112], [113], [114]
D1771		Desoximetasone (topical)	C22H29FO4	5311067	Minor		Inter Info	[112], [113], [114]
D1773		Diflorasone (topical)	C22H28F2O5	71415	Minor		Inter Info	[112], [113], [114]
D1786		Fluocinonide (topical)	C26H32F2O7	9642	Minor		Inter Info	[112], [113], [114]
D1788		Flurandrenolide (topical)	C24H33FO6	15209	Minor		Inter Info	[112], [113], [114]
D1813		Hydrocortisone (topical)	C21H30O5	5754	Minor		Inter Info	[112], [113], [114]
D1844		Methylprednisolone (topical)	C22H30O5	6741	Minor		Inter Info	[112], [113], [114]
D1869		Prednicarbate (topical)	C27H36O8	6714002	Minor		Inter Info	[112], [113], [114]
D1911		Triamcinolone (topical)	C21H27FO6	31307	Minor		Inter Info	[112], [113], [114]
D1916		Ulobetasol (topical)	C22H27ClF2O4	5311167	Minor		Inter Info	[112], [113], [114]

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