Drug General Information (ID: DDIQ48H6YD)
Drug Name			Alclometasone (topical)		Drug Info		Pioglitazone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Antidiabetic Agents
Structure

Mechanism of Alclometasone (topical)-Pioglitazone Interaction (Severity Level: Minor)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Alclometasone (topical)				Pioglitazone
Mechanism 1		Hyperglycemia				Antidiabetic agent
Key Mechanism Factor 1
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Pioglitazone when combined with Alclometasone (topical)
Mechanism 2		Hyperglycemic effects				Antidiabetic agent
Key Mechanism Factor 2
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Pioglitazone when combined with Alclometasone (topical)

References
1	Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42. [PMID: 3511355]
2	Product Information. Psorcon (diflorasone topical). Rhone-Poulenc Rorer, Collegeville, PA.
3	Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim. [PMID: 4682644]