Details of Drug

Drug General Information (ID: D1278)
Drug Name	Phenylephrine (ophthalmic)
Drug Type	Small molecule
Drug Synonymous	Cyclomydril; Dilatair; Dionephrine; Doktors; Duration; Fenilefrina; Isophrim; Isophrin; Mesaton; Mesatone; Mesatonum; Metaoxedrin; Metaoxedrine; Metaoxedrinum; Metasympatol; Metasynephrine; Metsatonum; Mezaton; Mydfrin; Neofrin; Neosynephrine; Nostril; Ocugestrin; Phenoptic; Phenylephrinum; Spersaphrine; Visadron; Alcon Efrin; Isopto Frin; Minims Phenylephrine; Nostril Spray Pump; Nostril Spray Pump Mild; Phenylephrine Minims; Prefrin Liquifilm; Relief Eye Drops for Red Eyes; Alconefrin Nasal Drops 12; Alconefrin Nasal Drops 25; Alconefrin Nasal Drops 50; Alconefrin Nasal Spray 25; Ah-Chew; Ak-dilate; Ak-nefrin; Fenilefrina [INN-Spanish]; I-Phrine; L-Phenylephedrine; L-Phenylephrine; M-Methylaminoethanolphenol; M-Oxedrine; M-Sympathol; M-Sympatol; M-Synephrine; Mydfrin (TN); Neo-Synephrine; Neo-Synephrine Nasal Drops; Neo-Synephrine Nasal Jelly; Neo-Synephrine Nasal Spray; Ocu-Phrin Sterile Eye Drops; Phenylephrine (INN); Phenylephrine Minims (TN); Phenylephrine [INN:BAN]; Phenylephrinum [INN-Latin]; R(-)-Phenylephrine; L-(3-Hydroxyphenyl)-N-methylethanolamine; L-1-(m-Hydroxyphenyl)-2-methylaminoethanol; L-m-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol; L-alpha-Hydroxy-beta-methylamino-3-hydroxy-L-ethylbenzene; Tannins, compds. with (R)-3-hydroxy-alpha-((methylamino)methyl)benzenemethanol; Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)-(9CI); (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol; (R)-2-Hydroxy-2-(3-hydroxyphenyl)-N-methylethylamine; (R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol; 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol Click to Show/Hide
Disease Class	ME07: Faecal incontinence; 5A02: Thyrotoxicosis
Therapeutic Class	Mydriatics/Decongestants
Structure
Structure	3D Structure		2D Structure
Formula	C9H13NO2
InChI	1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1
InChIKey	SONNWYBIRXJNDC-VIFPVBQESA-N
Canonical SMILES	CNCC(C1=CC(=CC=C1)O)O
External Link
	Pubchem ID	6041
	CAS Number	61-76-7
	CHEBI ID	8093
	TTD ID	D0O6IU
	VARIDT ID	DR01201

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM018 Non-CYP450 enzyme inhibition BM041 Additive hypertensive effects BM078 Increased risk of rapid heart rate BM089 Antagonize the effect of antihypertensive agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Phenylephrine (ophthalmic)
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[8]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[24], [25], [26]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[24], [25], [26]
D1036		Methylene blue	C16H18ClN3S	6099	Moderate		Inter Info	[24], [25], [26]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[24], [25], [26]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[24], [25], [26]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[24], [25], [26]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[24], [25], [26]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[24], [25], [29]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[24], [25], [26]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[24], [25], [26]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 70
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[1], [2], [3]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[1], [3], [4]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[1], [3], [4]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[1], [3], [4]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[1], [3], [4]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[9], [10]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[11], [12], [13]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[9], [10]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[9], [10]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[9], [10]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[17], [18], [19]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[9], [10]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[5], [4]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[9], [10]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[17], [18], [19]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[11], [12], [13]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[11], [12], [13]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[11], [12], [13]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[9], [10]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[9], [10]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[9], [10]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[9], [10]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[11], [12], [13]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[20], [21], [22]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[11], [12], [13]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[23]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[20], [21], [22]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[11], [12], [13]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[17], [18], [19]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[11], [12], [13]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[11], [12], [13]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[17], [18], [19]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[17], [18], [19]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[27], [5], [28]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[9], [10]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[9], [10]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[9], [10]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[20], [21], [22]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[17], [18], [19]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[11], [12], [13]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[11], [12], [13]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[9], [10]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[20], [21], [22]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[9], [10]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[9], [10]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[17], [18], [19]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[17], [18], [19]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[11], [12], [13]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[11], [12], [13]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[9], [10]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[9], [10]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[17], [18], [19]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[11], [12], [13]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[9], [10]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[17], [18], [19]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[17], [18], [19]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[17], [18], [19]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[17], [18], [19]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[11], [12], [13]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[30], [31], [32]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[33]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[9], [10]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[20], [21], [22]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[17], [18], [19]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[17], [18], [19]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[11], [12], [13]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[9], [10]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[9], [10]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[11], [12], [13]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[20], [21], [22]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[5], [6], [7]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[14], [15], [16]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[14], [15], [16]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[14], [15], [16]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[14], [15], [16]

References
1	Barthel W, Glusa E, Koth W "Interactions of dihydroergotamine with etilefrine in human leg veins in vitro and in situ." Int J Clin Pharmacol Ther Toxicol 25 (1987): 63-9. [PMID: 2881898]
2	Buchanan N, Cane RD, Miller M "Symmetrical gangrene of the extremities associated with the use of dopamine subsequent to ergometrine administration." Intensive Care Med 3 (1977): 55-6. [PMID: 561121]
3	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
4	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
5	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
7	Product Information. Neo-Synephrine (phenylephrine). Abbott Pharmaceutical, Abbott Park, IL.
8	Product Information. Azedra (iobenguane I-131). Progenics Pharmaceuticals, Inc., New York, NY.
9	Cass E, Kadar D, Stein HA "Hazards of phenylephrine topical medication in persons taking propranolol." Can Med Assoc J 120 (1979): 1261-2. [PMID: 221086]
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11	Levine MA, Leenen FH "Role of vagal activity in the cardiovascular responses to phenylephrine in man." Br J Clin Pharmacol 33 (1992): 333-6
12	Daelman F, Andrejak M, Rajaonarivony D, Bryselbout E, Jezraoui P, Ossart M "Phenylephrine eyedrops, systemic atropine and cardiovascular adverse events." Therapie 49 (1994): 467
13	Lai YK "Adverse effect of intraoperative phenylephrine 10%: case report." Br J Ophthalmol 73 (1989): 468-9
14	Gulati OD, Dave BT, Gokhale SD, Shah KM "Antagonism of adrenergic neuron blockade in hypertensive subjects." Clin Pharmacol Ther 7 (1966): 510-4. [PMID: 5939974]
15	Ziegler CH, Lovette JB "Operative complications after therapy with reserpine and reserpine compounds." JAMA 176 (1961): 114-7
16	Spiers AS, Calne DB "Action of dopamine on the human iris." Br Med J 4 (1969): 333-5
17	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
18	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
19	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
20	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
21	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
22	Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
23	Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
24	Cusson JR, Goldenberg E, Larochelle P "Effect of a novel monoamine-oxidase inhibitor, moclobemide on the sensitivity to intravenous tyramine and norepinephrine in humans." J Clin Pharmacol 31 (1991): 462-7. [PMID: 2050833]
25	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
26	Thompson DS, Sweet RA, Marzula K, Peredes JC "Lack of interaction of monoamine oxidase inhibitors and epinephrine in an older patient." J Clin Psychopharmacol 17 (1997): 322-3. [PMID: 9241014]
27	Cerner Multum, Inc. "Australian Product Information.".
28	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
29	Product Information. Xadago (safinamide). US WorldMeds LLC, Louisville , KY.
30	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
31	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
32	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
33	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.

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