Details of Drug

Drug General Information (ID: D1276)
Drug Name	Phenylephrine
Drug Type	Small molecule
Drug Synonymous	Cyclomydril; Dilatair; Dionephrine; Doktors; Duration; Fenilefrina; Isophrim; Isophrin; Mesaton; Mesatone; Mesatonum; Metaoxedrin; Metaoxedrine; Metaoxedrinum; Metasympatol; Metasynephrine; Metsatonum; Mezaton; Mydfrin; Neofrin; Neosynephrine; Nostril; Ocugestrin; Phenoptic; Phenylephrinum; Spersaphrine; Visadron; Alcon Efrin; Isopto Frin; Minims Phenylephrine; Nostril Spray Pump; Nostril Spray Pump Mild; Phenylephrine Minims; Prefrin Liquifilm; Relief Eye Drops for Red Eyes; Alconefrin Nasal Drops 12; Alconefrin Nasal Drops 25; Alconefrin Nasal Drops 50; Alconefrin Nasal Spray 25; Ah-Chew; Ak-dilate; Ak-nefrin; Fenilefrina [INN-Spanish]; I-Phrine; L-Phenylephedrine; L-Phenylephrine; M-Methylaminoethanolphenol; M-Oxedrine; M-Sympathol; M-Sympatol; M-Synephrine; Mydfrin (TN); Neo-Synephrine; Neo-Synephrine Nasal Drops; Neo-Synephrine Nasal Jelly; Neo-Synephrine Nasal Spray; Ocu-Phrin Sterile Eye Drops; Phenylephrine (INN); Phenylephrine Minims (TN); Phenylephrine [INN:BAN]; Phenylephrinum [INN-Latin]; R(-)-Phenylephrine; L-(3-Hydroxyphenyl)-N-methylethanolamine; L-1-(m-Hydroxyphenyl)-2-methylaminoethanol; L-m-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol; L-alpha-Hydroxy-beta-methylamino-3-hydroxy-L-ethylbenzene; Tannins, compds. with (R)-3-hydroxy-alpha-((methylamino)methyl)benzenemethanol; Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)-(9CI); (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol; (R)-2-Hydroxy-2-(3-hydroxyphenyl)-N-methylethylamine; (R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol; 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol Click to Show/Hide
Disease Class	ME07: Faecal incontinence; 5A02: Thyrotoxicosis
Therapeutic Class	Mydriatics/Decongestants
Structure
Structure	3D Structure		2D Structure
Formula	C9H13NO2
InChI	1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1
InChIKey	SONNWYBIRXJNDC-VIFPVBQESA-N
Canonical SMILES	CNCC(C1=CC(=CC=C1)O)O
External Link
	Pubchem ID	6041
	CAS Number	61-76-7
	CHEBI ID	8093
	TTD ID	D0O6IU
	VARIDT ID	DR01201

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM018 Non-CYP450 enzyme inhibition BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM061 Increased risk of hyperpyrexia BM078 Increased risk of rapid heart rate BM081 Increased risk of ventricular arrhythmias BM083 Potentiated the pharmacological effects (Unspecific) BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Phenylephrine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[15]
D1821		Iobenguane (I-123)	C8H10IN3	60860	Moderate		Inter Info	[103], [104], [105]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[110], [16], [39], [40], [9], [111], [19], [21], [22], [112], [23], [24], [31], [113], [33], [67], [109], [114], [36]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 92
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[4], [5], [6], [7]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[4], [7], [8]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[4], [7], [8]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3]
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[9], [10], [11]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[9], [10], [11]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[4], [7], [8]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[4], [5], [6], [12], [7], [8]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[55], [62], [74]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[75], [76]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[55], [62], [74]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[77], [78], [79]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[75], [76]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[75], [76]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[75], [76]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[83], [84], [85]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[75], [76]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[9], [8]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[9], [88], [89]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[55], [62], [74]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[75], [76]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[83], [84], [85]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[77], [78], [79]
D0124		Atropine (ophthalmic)	C17H23NO3	174174	Moderate		Inter Info	[77], [78], [79]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[77], [78], [79]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[55], [62], [74]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[77], [78], [79]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[75], [76]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[75], [76]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[75], [76]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[77], [78], [79]
D0399		Cyclopentolate (ophthalmic)	C17H25NO3	2905	Moderate		Inter Info	[77], [78], [79]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[90], [91], [92], [93], [94], [95]
D0460		Dexmethylphenidate	C14H19NO2	154101	Moderate		Inter Info	[55], [62], [74]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[77], [78], [79]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[55], [62], [74]
D0523		Doxapram	C24H30N2O2	3156	Moderate		Inter Info	[55], [62], [74]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[99]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[90], [91], [92], [93], [94], [95]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[83], [84], [85]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[77], [78], [79]
D0759		Homatropine	C16H21NO3	5282593	Moderate		Inter Info	[77], [78], [79]
D0760		Homatropine (ophthalmic)	C16H21NO3	5282593	Moderate		Inter Info	[77], [78], [79]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[77], [78], [79]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[83], [84], [85]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[83], [84], [85]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[40], [9], [106]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[75], [76]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[75], [76]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[75], [76]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[83], [84], [85]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[55], [62], [74]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[55], [62], [74]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[77], [78], [79]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[55], [62], [74]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[77], [78], [79]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[55], [62], [74]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[75], [76]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[90], [91], [92], [93], [94], [95]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[75], [76]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[75], [76]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[83], [84], [85]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[83], [84], [85]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[77], [78], [79]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[55], [62], [74]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[75], [76]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[83], [84], [85]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[77], [78], [79]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[75], [76]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[83], [84], [85]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[16], [17], [39], [9], [18], [42], [19], [20], [22], [23], [24], [25], [26], [27], [45], [29], [47], [30], [108], [64], [32], [34], [109], [35], [36]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[83], [84], [85]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[83], [84], [85]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[83], [84], [85]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[77], [78], [79]
D1451		Scopolamine (ophthalmic)	C17H21NO4	3000322	Moderate		Inter Info	[77], [78], [79]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[115]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[90], [91], [92], [93], [94], [95]
D1655		Tropicamide (ophthalmic)	C17H20N2O2	5593	Moderate		Inter Info	[77], [78], [79]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[83], [84], [85]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[77], [78], [79]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[75], [76]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[75], [76]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[77], [78], [79]
	Additive hypotensive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[100], [101], [102]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[100], [101], [102]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[100], [101], [102]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[100], [101], [102]
	Increased risk of hyperpyrexia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[37], [38]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[16], [17], [39], [40], [9], [41], [18], [42], [19], [20], [21], [22], [23], [24], [25], [26], [27], [43], [44], [28], [45], [46], [29], [47], [30], [48], [49], [50], [31], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [32], [33], [66], [67], [34], [35], [68], [69], [70], [36]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
	Increased risk of ventricular arrhythmias					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[96], [97], [98]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[96], [97], [98]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[86], [87], [13]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[40], [9], [107]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[86], [87], [13]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[86], [87], [13]
D0380		Colchicine	C22H25NO6	6167	Minor		Inter Info	[116], [117], [118]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[9], [13], [14]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[71], [72], [73]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[71], [72], [73]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[71], [72], [73]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [72], [73]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [72], [73]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [72], [73]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [72], [73]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [72], [73]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [72], [73]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[71], [72], [73]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[71], [72], [73]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[71], [72], [73]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[71], [72], [73]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[71], [72], [73]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[71], [72], [73]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[71], [72], [73]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[71], [72], [73]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[71], [72], [73]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[71], [72], [73]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[71], [72], [73]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[71], [72], [73]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[71], [72], [73]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[71], [72], [73]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[71], [72], [73]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[71], [72], [73]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[71], [72], [73]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[71], [72], [73]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[71], [72], [73]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[71], [72], [73]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[71], [72], [73]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[71], [72], [73]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[71], [72], [73]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[71], [72], [73]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[71], [72], [73]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[71], [72], [73]
	Antagonize the effect of antihypertensive agents					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[80], [81], [82]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[80], [81], [82]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[71], [72], [73]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[71], [72], [73]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[71], [72], [73]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[80], [81], [82]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[71], [72], [73]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[80], [81], [82]

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